|
Drugs & Behavior |
Back
to the Drug Store |
Back to
the checkout![]() |
View
Current Submisions![]() |
1.The drug that revolutionized (i.e. the most important
to) the treatment of mental illness in the U.S. in the mid 1950s was:
a. chlorpromazine
b. mebrobramate
c. thorazine
d. cocaine
e. two of the
above
2.Briefly explain the difference between a competitive antagonist and a non-competitive antagonist.
3.Why can it be said that ALL inverse agonists are antagonists, but NOT ALL antagonists can be called inverse agonists?
4.Explain the meaning of threshold dose, maximal response
dose, and ED50 in terms of a "typical" dose-response
function.
5.Drug administration via the oral route is usually the
safest route of drug administration. However, there are some
disadvantages associated with P.O. administration
via the mouth?
a. this route
cannot be used effectively during emergencies
b. drug absorption
is usually low, comparatively
c. the first-pass
effect is common using this route
d. administration
via the mouth can upset and irritate the stomach
e. none of the
above
6.Psychotropic drugs alter:
a. behavior
b. cognitive
functioning
c. emotions
d. both a and
b
7.Which of the following is false regarding therapeutic
ratio (TR)?
a. You want
the dose of the ED50 to be quite low
b. You want
the dose of the LD50 to be high
c. TR = ED50/LD50
d. TR indicates
how safe a drug is
e. As TR decreases
(< 1), safety decreases
8.Which of the following is false regarding synergism?
a. Synergism
is a situation whereby two drugs together produce a greater effect than
either drug produces alone.
b. Two kinds
of synergism are addition and potentiation
c. Potentiation
is where two drugs produce the same overt effect, and the effect of the
two drugs taken together
is the sum of their individual effects
d. Both a and
c
e. When determining
addition vs. potentiation, the D-Rs and MED of the two drugs need to be
established.
9.Drugs cross biological membranes by all of the following
ways except:
a. passive diffusion
b. integration
c. filtration
d. pinocytosis
10.The following are disadvantages of IV administration except:
a. absorption
more variable
b. clot formation
c. vessel irritation/collapse
d. both a and
c
11.Which of the following used the technique of long periods
sleep with bromides to treat schizophrenics?
a. Grilly
b. Pavlov
c. Freud
d. William James,
the first American psychologist
12.Briefly explain "key and lock" analogy and how it applies to the receptor (e.g. antagonist, agonist).
13.What are the advantages and disadvantages of the I.V. route of administration of drugs?
14.What are the factors that influence a drug's absorption? Briefly explain 3 factors.
15.Which of the following is NOT one of the primary ions for
conduction?
a. A-
b. Cl-
c. Ca++
d. K+
16.What are the forces that influence the concentrations of ions across neuronal membranes? Explain and give example(s).
17.The action potential is said to be an all-or-none response. What does this mean?
18.Each action potential has an absolute and relative refractory period. What is the difference between the two?
19.In relation to the drug experience, the set refers to:
a. the social
and physical environment in which the drug is taken.
b. how frequently
the drug is taken.
c. the psychological
makeup and the expectations of the individual taking the drug.
d. the individual's
unique biochemical makeup.
20.True or False: The criteria for what constitutes drug abuse are not at all related to one's culture and their time period.
21.MATCHING:
1. Group of
neuron cell bodies A. CEREBRAL CORTEX outside the CNS.
2. Conglomeration
of structures B. MEDULLA
3. Portion of
spinal cord through which sensory info travels C. LIMBIC SYSTEM
4. Thought to
play a key role in formation of memory and cog arousal D. Hypothalamus
5. Controls
automatic skeletal motor activities and coordinates balance E. CEREBELLUM
6. Controls
reflex functions such as respiration, heart rate, blood pressure, and vomiting.
F. NUCLEI
7. Regulates
the expression of fight, fright , feeding, and mating. G. GANGLIA
8. Is composed
fo the frontal, parietal, temporal, and occiptial lobes H. VENTRAL ROOT
9. Group of
neruon cell bodies inside the CNS. I. DORSAL ROOT
22.Ionizaton of a drug:
a. increases
it's solubility.
b. decreases
it's solubility.
c. neither increases
nor decreases it's solubility.
d. may increase
or decrease it's solubility depending on the surrounding conditions.
23.Drug tolerance:
a. is the opposite
of sensitization.
b. occurs in
response to depleated drug administration.
c. results in
greater amounts of drug being required to reinstate the initial effect.
d. two of the
above.
e. all of the
above.
24.List the metabolic pathway for the manufacture of catecholamine
NT's, begining with the amino acid and including all
enzymes.
25.For what NT does LSD serve as an agonist?
a. Serotonin
b. Norepinephrine
c. GABA
d. Tyrosine
26.Which is a characteristic feature of tolerance?
a. Occurs in
response to repeated drug adminstration.
b. Loss of effect
relative to initial impact.
c. Results in
greater amounts of drug being required to reinstate that initial effect.
d. All of the
above.
27.Which of the following can be considered the opposite of drug
tolerance?
a. Homeostasis
b. Instrumental
conditioning
c. Sensitization
d. Habituation
28.List the three major forms of drug classification and briefly explain their interrelationships.
29.WHICH IS AN EXAMPLE OF STATE DEPENDENT LEARNING?
a. TYING A STRING
AROUND YOUR PINKY TO REMEMBER HOMEWORK.
b. WRITING DOWN
SHORT HAND NOTES.
c. GETTING DRUNK
AT A PARTY AND GETTING A PHONE NUMBER AND CALLING IT THE
NEXT DAY WHEN
YOU ARE SOBER.
d. GETTING A
PHONE NUMBER AT A PARTY AND FORGETTING IT THE NEXT DAY, THEN
REMEMBERING
IT THE NEXT TIME YOU WERE DRUNK.
30.WHAT DID THE HUMPHREY-DURHAM ACT REQUIRE FOR DRUG DISTRIBUTION?
31.EXPLAIN THE DIFFERENCE BETWEEN DRUG TOLERANCE BEING PHARACODYNAMIC
AND
CONTEXT-SPECIFIC.
32.LIST THE THREE CHARATERISTICS OF TOLERANCE FEATURES.
33.IN THE PARASYMPATHETIC, THE GLANGLIA ARE:
a. CLOSER TO
THE TARGET ORGAN.
b. CLOSER TO
THE SPINAL CORD.
c. THE SAME
DISTANCE BETWEEN THE SPINAL CORD AND THE TARGET ORGAN.
d. NONE OF THE
ABOVE.
34.Which of the following is not a part of a motor neuron?
a. axon
b. mitochondrion
c. dendrite
d. glial cell
e. terminal
button
35.With regards to a motor neuron "firing,"ion channels exist
for all of the followin except:
a. sodium
b. magnesium
c. chloride
d. potassium
e. calcium
36.Which of the following is a ligand?
a. axon
b. tendon
c. neurotransmitter
d. receptor
e. caveat
37.An antagonist does which of the following?
a. appears to
act through the same receptor as an agonist, but produces effects opposite
of those of the agonist
b. has affinity
for and capability of activating receptor
c. always decreases
bloodflow to the organ which it is affecting
d. always increases
bloodflow to the organ which it is affecting
e. blocks action
of agonists
38.Schedule II of the schedule-controlled drugs contains:
a. marijuana
b. some currently
accepted medical use drugs which also have high abuse potential
c. no currently
U.S. accepted medical use drugs which also have high abuse potential
d. alcohol
e. no currently
accepted medical use drugs which also have no abuse potential
39.. What is the difference between a drug and a ligand?
40.Implications for drug entry across the BBB include
a. drug molecule
has to be very small
b. lipid soluble
c. active transport
d. pinocytosis
e. all of the
above
41.Name the three drug passages.
42.What is the critical level of a nerve impulse?
a. 50mV
b. 90mV
c. 70mV
d. none of the
above
43.What is tachyphylaxis?
44.True or False. It is possible to be dependent on a drug without ever abusing the drug.
45.Which process(es) are involved in context-specific tolerance?
A. habituation
B. Pavlovian
conditioning
C. instrumental
conditioning
D. only A. and
C.
E. all of the
above
46.Which route of drug administration involves first pass metabolism?
47.True or False. A drug's therapeutic index is often specified in terms of the drug's LD50 relative to the drug's ED50.
48.If a drug has a plasma half-life of 4 hours, and 20 milligrams
of the drug are administered, how many milligrams of the
drug will be present after 8 hours?