Brent M. Znosko, PhD
Associate Professor of Chemistry
225 Monsanto Hall
Associate Professor of Chemistry, Saint Louis University (2010-present)
Allegheny College, B.S. in Chemistry, 1999
The main focus of the Znosko lab is to better understand nucleic acid thermodynamics, energetics, secondary structures, and three-dimensional structures. Ongoing projects include: understanding the thermodynamics and structure of RNA secondary structure motifs; thermodynamic, energetic, and structural characterization of short RNA oligomers containing non-standard nucleotides; and investigating the role of substituent-substituent interactions in DNA/RNA base stacking and in DNA/RNA-intercalator stacking. We utilize wet chemistry, UV/Visible spectroscopy, NMR, computational chemistry, various computer programs (from our lab and other labs), and molecular visualization software. Visit the Znosko Lab Website here.