Saint Louis University

Faculty Biography

James L. Edwards, Ph.D.
Assistant Professor of Chemistry

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Contact Information

103 Monsanto Hall
Department of Chemistry
Saint Louis University
3501 Laclede Ave
St Louis, MO 63130
(314) 977-3624
jedward5 at slu dot edu

Career History

Assistant Professor, Saint Louis University, 2012-present
Assistant Professor, Institute for Bioscience and Biotechnology Research, University of Maryland 2008-2012


Postdoctoral Studies University of Michigan, Juvenile Diabetes Research Foundation Center for the Study of Complications in Diabetes
Ph.D. in Chemistry University of Michigan, Ann Arbor, 2006
M.S. in Chemistry Saint Louis University, St Louis, MO 2001
B.A. in Chemistry. Saint Louis University, St Louis, MO 1999


The Edwards group develops novel metabolomic methods for elucidating biochemical changes in diabetic tissue and cells. The collective group of small endogenous molecules in a biological sample contains a large range of concentrations and polarities and a high degree of structural diversity.  To analyze such a diverse group of molecules, improvements in sample preparation, separations and mass spectrometric (MS) techniques are required.  Major projects in our laboratory include 1) developing a biomimetic platform for the culture and metabolomics sample preparation of endothelial cells, 2) multidimensional capillary separation of acidic metabolites, and 3) tagging of metabolites based on functional groups so as to selectively improve ionization and thus MS signal.   We apply these methods to the field of diabetic complications for the discovery of pathways and metabolites which change in response to hyperglycemia and oxidative stress.  Our recent studies have detected over 4,000 metabolic changes from diabetic aorta using a capillary LC-MS based approach.

Higher purpose. Greater good.
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