Saint Louis University

Faculty Biography

John L. Grutsch, PhD

Assistant Professor of Chemistry

Contact Information

206 Monsanto Hall
314-977-2845
grutschjl@slu.edu

Education

Ph.D. Chemistry, Purdue University, West Lafayette, IN. Campus 2014
M.S. Chemistry, Purdue University, Indianapolis, IN. Campus 2000
B.S. Chemistry, Purdue University, Fort Wayne, IN. Campus 1993

Previous Employment

Organic Chemistry, Eli Lilly and Company, Indianapolis, IN. 1993 - 2007

Publications

Szeto, A. K.; Tessman, J. M.; Grutsch, J. L.; Bodner, G. M. CHED 344-Progress in developing a nanoscience concept inventory for undergraduate students. Abstracts of the American Chemical Society. 2008, 236.

Al-Awar, R. S.; Ray, J. E.; Hecker, K. A.; Huang, J. P.; Waid, P. P.; Shih, C. A.; Brooks, H. B., Spencer, C. D.; Watkins, S. A.; Patel, B. R.; Stamm, N. B.; Ogg, C. A.; Schultz, R. M.; Considne, E. L.; Faul, M. M.; Sullivan, K. A.; Kollis, S. P.; Grutsch, J. L.; Joesph, S. 1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2004, 14(12), 3217-3220.

Faul, M. M.; Sullivan, K. A.; Grutsch, J. L.; Winneroski, L. L.; Shih, C.; Sanchez-Martinez, C.; Cooper, J. T. Synthesis of indolo 2,3- carbazole glycoside analogs of Rebeccamycin: inhibitors of cyclin D1-CDK4. Tetrahedron Letters. 2004, 45(5), 1095-1098.

Faul, M. M.; Engler, T. A.; Sullivan, K. A.; Grutsch, J. L.; Clayton, M. T.; Martinelli, M. J.; Pawlak, J. M.; LeTourneau, M.; Coffey, D. S.; Pedersen, S. W.; Kolis, S. P.; Furness, K.; Malhotra, S.; Al-Awar, R. S.; Ray, J. E. Synthetic approaches to indolo 6,7- pyrrolo 3,4-carbazoles: Potent cyclin D1/cdk4 inhibitors. Journal of Organic Chemistry. 2004, 69(9), 2967-2975.

Hansen, M. M.; Clayton, M. T.; Godfrey, A. G.; Grutsch, J. L.; Keast, S. S.; Kohlman, D. T.; McSpadden, A. R.; Pedersen, S. W.; Ward, J. A.; Xu, Y. C.; Lithiated benzothiophenes and benzofurans require 2-silyl protection to avoid anion migration. Synlett. 2004, 8, 1351-1352.

Faul, M. M.; Grutsch, J. L.; Kobierski, M. E.; Kopach, M. E.; Krumrich, C. A.; Staszak, M. A.; Udodong, U.; Vicenzi, J. T.; Sullivan, K. A. Strategies for the synthesis of N- (azacycloallkyl) bisindolylmaleimides: selective inhibitors of PKC beta. Tetrahedron 2003, 59(36), 7215-7229.

Kolis, S. P.; Clayton, M. T.; Grutsch, J. L.; Faul, M. M. Synthesis of 7-cyano and 7- acetamido-indoles via cyanocarbonation/hydrogenation of 7-formyl indole. Tetrahedron Letter. 2003, 44(30), 5707-5710.

Sanchez-Martinez, C.; Faul, M. M.; Shih, C.; Sullivan, K. A.; Grutsch, J. L.; Cooper, J. T.; Kolis, S. P.; Synthesis of aryl- and heteroaryl a pyrrolo 3,4- carbazoles. Journal of Organic Chemistry. 2003, 68(21), 8008-8014.

Udodong, U. E.; Hansen, M. M.; Verral, D. E.; Harkness, A. R.; Grutsch, J. L.; Miller, W. D.; Astleford, B. Selective methylphosphonylation of an echinocandin  analog derived from LY303366. Tetrahedron. 2003, 59(15), 2667-2672.

Monn, J. A.; Valli, M. J.; Massey, S. M.; Hansen, M. M.; Kress, T. J.; Wepsiec, J. P.; Harkness, A. R.; Grutsch, J. L.; Wright, R. A.; Johnson, B. G.; Andis, S. L.; Kingston, A.; Tomlinson, R.; Lewis, R.; Griffey, K. R.; Tizzano,. J. P.; Schoepp, D. D. Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo 3.1.0 hexane-2,6-dicarboxylic acid (LY354740): Identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. Journal of Medicinal Chemistry. 1999, 42(6), 1027- 1040.

Udodong, U. E.; Turner, W. W.; Astleford, B. A.; Brown, F.; Clayton, M. T.; Dunlap, S. E.; Frank, S. A.; Grutsch, J. L.; LaGrandeur, L. M.; Verral, D. E.; Werner, J. A. Studies on the phosphorylation of LY303366. Tetrahedron Letters, 1998, 39(34), 6115-6118.

Udodong, U. E.; Hansen, M. M.; Verral, D. E.; Harkness, A. R.; Grutsch, J. L.; Miller, W. D.; Astleford, B. A. A convenient reagent for the synthesis of methylphosphonates. Abstracts of papers of the American Chemical Society. 1997, 214, 248-ORGN.

Hansen, M. M.; Grutsch, J. L. Lead catalysis of a thiocarbonyl reduction using zinc dust. Organic Process Research & Development. 1997, 1(2), 168-171.

Hansen, M. M.; Grutsch, J. L. Lead catalysis of a thiocarbonyl reduction using zinc dust. Abstracts of Papers of the American Chemical Society. 1996, 211, 216-ORGN.

Linn, D. E.; Rummage, S. D.; Grutsch, J. L. Reactions of Ni(III)(cyclam) with aqueous sulfur dioxide - exhibition of a deuterium-isotope effect and catalyst by chloride and bromide. International Journal of Chemical Kinetics. 1993, 25(6), 489-507.

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