Saint Louis University

Animal model for Parkinson's disease

Animal model for Parkinson's disease

Research Tool

Inventors: Vijaya Kumar, William Burke, Michael Panneton

Disclosed are methods and compositions for an animal model of Parkinson's disease. In particular, disclosed is the use of antisense compounds to inhibit the expression of ALDH1A1 in the substantia nigra of an animal brain for the purpose of creating an animal that will displays the symptoms of a human with Parkinson's Disease, including various biochemical, histological, and behavioral characteristics. Also disclosed are methods for using the animal model for Parkinson's disease to test potential therapeutic agents for Parkinson's disease.

U.S. patent pending

Stephanie Kimzey, MBA


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