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- A Modern Approach to Wing Warp for Aircraft Control
- Treatment Of Liver Fibrosis Following Hepatic Injury By Selective Killing Of Activated Liver Stellate Cells
- Compositions and Methods for Treating and Diagnosing Hepatoma
- Vaccine Compositions and Methods That Increase Safety of Anti-Viral Vaccination Without Loss of Efficacy
- Automatic Pressure-Locking Valve Prevents CSF Loss and Herniation During Lumbar Puncture When Intracranial Pressure Is Elevated.
- Immortal Differentiated Type II Lung Epithelial Cell Line (T7)
- Human A Rapid, Reliable Bedside Diagnostic Method For Accurately Determining Feeding Tube Placement In Respiratory Tract, Stomach, Or Small Bowel Of Patients Prior to Enteral Nutrient Administration.
- Human Natural Killer Cell Line - NK 3.3:
- Factor IXa Protease Helix-330 (Region 1)
- In Vitro Method for Concerted Integration of Donor DNA Molecules Into Target DNA Using Retroviral Integrase and a Procedure for Evaluation of Donor DNA Integration.
- SRCAP: A Novel Transcription Protein Having Therapeutic Target and Diagnostic Target Product Development Potential.
- C-Terminal Binding Protein Interacting Protein (CtIP):
- Novel Anti-Coagulation Therapeutics: Agents That Effectively Inhibit Binding of Factor VIIIa (Region 3) With Factor IXa (Region 2) Without Activating Factor X.
- Genetically Modified Activated Protein C with Reduced Anticoagulant Properties
- C22: A Conditionally Immortalized Mouse Clara Cell Line
Human Natural Killer Cell Line - NK 3.3:
Inventor: Dr. Jacki Kornbluth
Natural killer (NK) cells act as an important defense against malignancy through their ability to inhibit tumor metastases and destroy solid tumors and hematopoietic tumors. In addition natural killer cells have anti-microbial activity, giving them a role in combating infectious diseases caused by bacteria, funji, yeast and protozoal parasites. NK cells also target and kill cells that are infected with various types of viruses including herpes, influenza, hepatitis, pox and orthomyxovirus.
The inherent cytotoxicity of NK cells can be significantly enhanced by interaction of the NK cells with various cytokines and interferon via receptor-specific interactions. Such agents also induce the production of interferon-gamma by NK cells. A human natural killer cell line, NK 3.3, was established from soft agarose cloning of primary MLC activated cells in a medium containing interleukin-2. NK 3.3 cells mediate strong and exclusive natural killer cell activity and lack the pan T-cell marker as well as markers associated with T-cell subsets Morphologic, histochemical and phenotypic characterizations showed that the NK 3.3 cell line is similar to members of the large granular lymphocyte population that contains the bulk of the NK cell population. NK 3.3 cells are CD3-, CD4-, CD8-, CD2+, CD16+, CD56+.
They are capable of strong NK cell lysis of sensitive target cells. NK 3.3 cells have been shown to kill by both perforin/granzyme mediated granule exocytosis and by Fas-mediated killing. In addition, through their expression of the Fc receptor CD16, NK 3.3 cells mediate antibody dependent cellular cytotoxicity (ADCC). When activated by cytokines, such as IL-2 or interferons IL-12 or IL-15, NK 3.3 cells secrete interferon-gamma.
The human natural killer cell line, NK 3.3, is useful screening target for assessing the potential of therapeutic drug candidates to increase or decrease NK cell cytolytic function and for their ability to modulate the level of production of interferon-gamma production.
Keywords: NK cells; anti-angiogenesis; angiogenesis; cancer; metastases; anti-virus
Reference Number: SLU-1011