Yie-Hwa Chang, Ph.D.
Biochemistry and Molecular Biology
Understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino terminal processing of eukaryotic proteins and its role in angiogenesis.
Our lab is interested in understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino-terminal processing of eukaryotic proteins and its role in angiogenesis. Recently, the type-2 MetAP was found to be the molecular target for angiogenesis inhibitors, TNP-470 and ovalicin. Angiogenesis is the process of new blood vessel formation. It plays very important roles in both physiological states and a variety of pathological states
Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients:
frequency, outcomes, and risk factors
Metheny NA, Clouse RE, Chang YH, Stewart BJ, Oliver DA and Kollef MH
Pubmed | Crit. Care Med.
A dominant negative mutation in Saccharomyces cerevisiae methionine aminopeptidase-1
affects catalysis and interferes with the function of methionine aminopeptidase-2
Klinkenberg M, Ling C and Chang YH
Pubmed | Arch. Biochem. Biophys.