Yie-Hwa Chang, Ph.D.

Associate Professor
Biochemistry and Molecular Biology


Research

Understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino terminal processing of eukaryotic proteins and its role in angiogenesis.

Research Interests

Our lab is interested in understanding how two distinct eukaryotic methionine aminopeptidases (MetAPs) function in the amino-terminal processing of eukaryotic proteins and its role in angiogenesis. Recently, the type-2 MetAP was found to be the molecular target for angiogenesis inhibitors, TNP-470 and ovalicin. Angiogenesis is the process of new blood vessel formation. It plays very important roles in both physiological states and a variety of pathological states

Publications

Recent

Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes
Basu A, Saito K, Meyer K, Ray RB, Friedman SL, Chang YH and Ray R
Pubmed | Apoptosis

Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes, and risk factors
Metheny NA, Clouse RE, Chang YH, Stewart BJ, Oliver DA and Kollef MH
Pubmed | Crit. Care Med.

N-terminal methionine removal and methionine metabolism in Saccharomyces cerevisiae
Dummitt B, Micka WS and Chang YH
Pubmed | J. Cell. Biochem.

Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae
Dummitt B, Fei Y and Chang YH
Pubmed | Protein Pept. Lett.

A dominant negative mutation in Saccharomyces cerevisiae methionine aminopeptidase-1 affects catalysis and interferes with the function of methionine aminopeptidase-2
Klinkenberg M, Ling C and Chang YH
Pubmed | Arch. Biochem. Biophys.