Maureen Donlin, Ph.D.

Research Professor
Biochemistry and Molecular Biology


Research

Studies on the cell wall integrity signaling pathway in the human fungal pathogen Cryptococcus neoformans

Research Interests

The human fungal pathogen, Cryptococcus neoformans, is the focus of research in our laboratory. One arm of our research is to understand how C. neoformans regulates and remodels its cell wall in response to stress and antifungal therapies. A second arm of our research is to identify novel small molecules that can inhibit growth of the fungus and potentially be developed into new anti-fungal therapies.

Publications

Recent

Troponoids Can Inhibit Growth of the Human Fungal Pathogen Cryptococcus neoformans
Donlin MJ, Zunica A, Lipnicky A, Garimallaprabhakaran AK, Berkowitz AJ, Grigoryan A, Meyers MJ, Tavis JE and Murelli RP
Pubmed | Antimicrob. Agents Chemother.

Hepatitis B virus genetic diversity has minimal impact on sensitivity of the viral ribonuclease H to inhibitors
Lu G, Villa JA, Donlin MJ, Edwards TC, Cheng X, Heier RF, Meyers MJ and Tavis JE
Pubmed | Antiviral Res.

A Functional Interplay between Human Immunodeficiency Virus Type 1 Protease Residues 77 and 93 Involved in Differential Regulation of Precursor Autoprocessing and Mature Protease Activity
Counts CJ, Ho PS, Donlin MJ, Tavis JE and Chen C
Pubmed | PLoS ONE

Checkpoint blockade immunotherapy relies on T-bet but not Eomes to induce effector function in tumor-infiltrating CD8+ T cells
Berrien-Elliott MM, Yuan J, Swier LE, Jackson SR, Chen CL, Donlin MJ and Teague RM
Pubmed | Cancer Immunol Res

HCV genome-wide genetic analyses in context of disease progression and hepatocellular carcinoma
Donlin MJ, Lomonosova E, Kiss A, Cheng X, Cao F, Curto TM, Di Bisceglie A and Tavis JE
Pubmed | PLoS ONE