Dale Dorsett, Ph.D.

Professor
Biochemistry and Molecular Biology


Research

Chromosome structure control of gene expression during development using

Research Interests

We use Drosophila molecular genetics to understand how chromosome structure controls gene expression during development. Our studies have shed light on the molecular mechanisms of Cornelia de Lange syndrome, which causes diverse developmental deficits in humans.

Publications

Recent

Cornelia de Lange syndrome and molecular implications of the cohesin complex: Abstracts from the 7th biennial scientific and educational symposium 2016
Kline AD, Krantz ID, Deardorff MA, Shirahige K, Dorsett D, Gerton JL, Wu M, Mehta D, Mills JA, Carrico CS, Noon S, Herrera PS, Horsfield JA, Bettale C, Morgan J, Huisman SA, Moss J, McCleery J, Grados M, Hansen BD, Srivastava S, Taylor-Snell E, Kerr LM, Katz O, Calof AL, Musio A, Egense A and Haaland RE
Pubmed | Am. J. Med. Genet. A

Measuring Sister Chromatid Cohesion Protein Genome Occupancy in Drosophila melanogaster by ChIP-seq
Dorsett D and Misulovin Z
Pubmed | Methods Mol. Biol.

Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements
Swain A, Misulovin Z, Pherson M, Gause M, Mihindukulasuriya K, Rickels RA, Shilatifard A and Dorsett D
Pubmed | PLoS Genet.

Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes
Kreienkamp R, Croke M, Neumann MA, Bedia-Diaz G, Graziano S, Dusso A, Dorsett D, Carlberg C and Gonzalo S
Pubmed | Oncotarget

The Drosophila melanogaster model for Cornelia de Lange syndrome: Implications for etiology and therapeutics
Dorsett D
Pubmed | Am J Med Genet C Semin Med Genet