Tomasz Heyduk, Ph.D.

Professor
Biochemistry and Molecular Biology


Research

Mechanisms of transcription regulation and development of novel sensors for biomolecule detection and imaging.

Research Interests

Our lab has two major research interests: mechanisms of transcription regulation and development of novel sensors for biomolecule detection and imaging. Our interest in transcription regulation is to understand the mechanism of transcription initiation by bacterial and archaeal RNA polymerases. Our primary focus in sensor research is to develop robust highly specific and sensitive molecular sensors that could be utilized in research, medical diagnosis and pathogen detection.

Publications

Recent

RNA polymerase motions during promoter melting
Feklistov A, Bae B, Hauver J, Lass-Napiorkowska A, Kalesse M, Glaus F, Altmann KH, Heyduk T, Landick R and Darst SA
Pubmed | Science

Real-Time Observation of Backtracking by Bacterial RNA Polymerase
Lass-Napiorkowska A and Heyduk T
Pubmed | Biochemistry

Next Generation Sequencing-based analysis of RNA polymerase functions
Heyduk T and Heyduk E
Pubmed | Methods

Ribosome display enhanced by next generation sequencing: a tool to identify antibody-specific peptide ligands
Heyduk E and Heyduk T
Pubmed | Anal. Biochem.

Kinetics of promoter escape by bacterial RNA polymerase: effects of promoter contacts and transcription bubble collapse
Ko J and Heyduk T
Pubmed | Biochem. J.