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Sergey Korolev, Ph.D.

Associate Professor
Biochemistry and Molecular Biology


Research

Structure-functional studies of DNA recombination, replication and repair proteins.

Research Interests

Our lab studies the mechanism of protein function at the atomic resolution level utilizing X-ray crystallography and biochemical approaches. The main focus is recombination mediator proteins (RMPs), which are essential for genome stability and DNA repair in all organisms.

Publications

Recent

Advances in structural studies of recombination mediator proteins
Korolev S
Pubmed | Biophys. Chem.

Erratum to: The loop-less ™Cdc34 E2 mutant defective polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2
Lass A, Cocklin R, Scaglione KM, Skowyra M, Korolev S, Goebl M and Skowyra D
Pubmed | Cell Div

A MUB E2 structure reveals E1 selectivity between cognate ubiquitin E2s in eukaryotes
Lu X, Malley KR, Brenner CC, Koroleva O, Korolev S and Downes BP
Pubmed | Nat Commun

Rous sarcoma virus synaptic complex capable of concerted integration is kinetically trapped by human immunodeficiency virus integrase strand transfer inhibitors
Pandey KK, Bera S, Korolev S, Campbell M, Yin Z, Aihara H and Grandgenett DP
Pubmed | J. Biol. Chem.

High resolution crystal structure of human β-glucuronidase reveals structural basis of lysosome targeting
Hassan MI, Waheed A, Grubb JH, Klei HE, Korolev S and Sly WS
Pubmed | PLoS ONE