Nicola Pozzi, Ph.D.
Biochemistry and Molecular Biology
Molecular mechanisms of thrombosis and immunothrombosis.
In our laboratory, we strive to understand the pathophysiological mechanisms that lead to thrombosis and immunothrombosis, an innate immune response that links coagulation to the recognition, containment and destruction of microbial pathogens. To achieve our goals, we apply a unique combination of biochemistry, protein engineering, X-ray crystallography, single molecule fluorescence biophysics (smFRET and FCS) and surface plasmon resonance (SPR).
Molecular mapping of α-thrombin (αT)/β2-glycoprotein I (β2GpI) interaction reveals
how β2GpI affects αT functions
Acquasaliente L, Peterle D, Tescari S, Pozzi N, Pengo V and De Filippis V
Pubmed | Biochem. J.
Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent
Induction of Optimal CD8 T Cell Protective Immunity
Eickhoff CS, Zhang X, Vasconcelos JR, Motz RG, Sullivan NL, O’Shea K, Pozzi N, Gohara DW, Blase JR, Di Cera E and Hoft DF
Pubmed | PLoS Pathog.