Frances Yap, Ph.D.

Associate Professor
Biochemistry and Molecular Biology


Research

Mechanism of translational regulation and the molecular responses of ribosome tunnel to different antibiotics and nascent polypeptides.

Research Interests

Few biochemical reactions are as critical for life as translation. We are interested in understanding the functional consequences of arrested translation (or "ribosome stalling") for controlling gene expression and protein biogenesis using genome-wide proteomics, next-generation sequencing, bacterial genetics and biochemistry. We also aim to investigate the selectivity and resistance properties of antibiotics that target the ribosome tunnel. This work will help in the development of more effective antimicrobial drugs.

Publications

The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling
Dzyubak E and Yap MN
Pubmed | Antimicrob. Agents Chemother.

Ribosome hibernation factor promotes Staphylococcal survival and differentially represses translation
Basu A and Yap MN
Pubmed | Nucleic Acids Res.

Sequence selectivity of macrolide-induced translational attenuation
Davis AR, Gohara DW and Yap MN
Pubmed | Proc. Natl. Acad. Sci. U.S.A.

The double life of antibiotics
Yap MN
Pubmed | Mo Med

Mutations in the Escherichia coli ribosomal protein L22 selectively suppress the expression of a secreted bacterial virulence factor
Yap MN and Bernstein HD
Pubmed | J. Bacteriol.