Frances Yap, Ph.D.
Biochemistry and Molecular Biology
Mechanism of translational regulation and the molecular responses of ribosome tunnel to different antibiotics and nascent polypeptides.
Few biochemical reactions are as critical for life as translation. We are interested in understanding the functional consequences of arrested translation (or "ribosome stalling") for controlling gene expression and protein biogenesis using genome-wide proteomics, next-generation sequencing, bacterial genetics and biochemistry. We also aim to investigate the selectivity and resistance properties of antibiotics that target the ribosome tunnel. This work will help in the development of more effective antimicrobial drugs.