Daniel S. Zahm, Ph.D.
Pharmacological and Physiological Science
Ph.D., Pennsylvania State University, 1982
Department of Anatomy and Neurobiology
Saint Louis University School of Medicine
St. Louis, MO
Research Associate 1982-1985
Departments of Neurology, Neurosurgery and Otolaryngology
University of Virginia School of Medicine
The laboratory seeks to understand fundamental patterns of organization in the basal forebrain, how forebrain systems contribute to behavioral synthesis and brain development and what the vulnerabilities of different forebrain systems are in circumstances leading to neurodegeneration.
Select Papers from 98 (citations from GoogleScholar as of 7/11/2014):
Zahm DS, Schwartz ZM, Lavezzi,HN, Yetnikoff L, Parsley KP (2014): Comparison of the locomotor activating effects of bucuculline infusions into the preoptic area and ventral pallidum. Brain Struct Function (cited by 2).
Zahm DS, Parsley KP, Schwartz ZM, Cheng AY: Connections of the accumbal ‘hedonic hotspot’ of Pecina and Berridge with commentary on the transitional nature of basal forebrain’boundaries’. J. Comp. Neurol.521:50-68, 2013 (cited by 17).
St.Onge JR, Stopper CM, Zahm DS, Floresco SB: Separate neural circuits bias choice towards risky or certain options.
J Neurosci, 32:2886-2899, 2012 (cited by 2).
Zahm DS, Cheng AY, Lee TJ, Ghobadi CW, Schwartz ZM, Geisler S, Parsely KP, Gruber C, Veh RW: Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors. J Comp Neurol 519:3159-3188, 2011 (cited by 21).
Lavezzi HN, Parsley KP, Zahm DS: Mesopontine rostromedial tegmental nucleus neurons projecting to the dorsal raphe and pedunculopontine tegmental nucleus: psychostimulant-elicited Fos expression and collateralization. Brain Structure & Function 217:719-734, 2012 (cited by 7).
Lavezzi HN, Zahm DS: The mesopontine tegmental nucleu: an integrative modulator of the reward system. Basal Ganglia 1:191-200, 2011 (cited by 15) .
Zahm, D.S., Pharmacological approach to the treatment of addiction: persisting challenges. Missouri Medicine 107:276-280, 2010 (cited by 4).
Zahm, D.S., Becker M.L., Freiman A.J., Strauch S., DeGarmo B., Geisler S., Meredith G.E., and Marinelli M.: Fos after single and repeated self-administration of cocaine and saline in the rat: emphasis on the basal forebrain and recalibration of expression. Neuropsychopharmacology, 35:445-463, 2010 (cited by 30).
Jhou, TC., Geisler, S., Marinelli, M., and Zahm, D.S.: Medial tegmental nucleus: a mesopontine structure targeted by the lateral habenula that projects to the ventral tegmental area and substantia nigra compacta. J . Comp. Neurol. 513:566-596, 2009 (cited by 129).
Geisler, S., Marinelli, M., DeGarmo, B., Becker M.L., Freiman, A.J., Beales, M., Meredith, G.E., and D.S. Zahm: Prominent activation of brainstem and pallidal afferents of the ventral tegmental area by cocaine. Neuropsychopharmacology, 33:2688-2700, 2008 (26).
Zahm, D.S.: The dopaminergic projection system, basal forebrain macrosystems, and conditioned stimuli. CNS Spectrums 13:887-892, 2008 (cited by 14).
Geisler, S., Derst, C., Veh, R.W. and D.S. Zahm: Glutamatergic afferents of the ventral tegmental area in the rat. J. Neurosci. 27:5730-5743, 2007 (cited by 228).
Zahm, D.S. The evolving theory of basal forebrain "functional anatomical macrosystems. Neurosci. Biobehav. Rev., 30:148-172, 2006 (cited by 80).
Reynolds, S.M., and D.S. Zahm: Specificity in the projections of prefrontal and insular cortex to ventral striatopallidum and extended amygdala. J. Neurosci. 25:11757-11767, 2005 (cited by 102).
Geisler, S., and D.S. Zahm: Afferents of the ventral tegmental area in the rat - anatomical substratum for integrative functions. J. Comp. Neurol. 490:270-294, 2005 (cited by 200).
Zahm, D.S.: An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens. Neurosci. Biobehav. Rev. 24:85-105, 2000 (cited by 360).
Brog, J.S., A. Salypongse, A.Y. Deutch and D.S. Zahm: The patterns of afferent innervation of the core and shell in the "accumbens" part of the rat ventral striatum: Immunohistochemical detection of retrogradely transported Fluoro-Gold. J. Comp. Neurol., 338:255-278, 1993 (cited by 783).
Zahm, D.S. and J.S. Brog: Commentary: On the significance of the core-shell boundary in the rat nucleus accumbens. Neuroscience 50:751-767, 1992 (cited by 804).
Selected Book Chapters (from 11):
Zahm, D.S.: Accumbens in a Functional-Anatomical Systes Context: In: (David H, ed.) The nucleus accumbens: neurotransmitters and related behaviors, Transworld Research Network-Research Signpost, Kerala, India, pgs. 1-37, 2008.
Zahm, D.S., and L. Heimer: Limbic System. In: (Binder MD, Hirokawa N and Windhorst U, eds.) Encyclopedia of Neuroscience, Vol. 3 H-M, Springer, pgs. 2157-2161, 2009.
Heimer, L., Van Hoesen, G.W., Trimble, M., Zahm, D.S. Anatomy of Neuropsychiatry. The New Anatomy of the Basal Forebrain and its Implications for Neuropsychiatric Illness. Elsevier, Amsterdam. 2008.
Convergent vs. Parallel Striatal Afferents
Honors and Awards
Leverhulme Visiting Professorship,
University of St. Andrews, St. Andrews,
Scotland, June-December, 2000
Forbairt Visiting Professorship,
Royal College of Surgeons and Trinity College,
Dublin, June - July, 1997
Professional Organizations and Associations
Editorial Boards: Neuroscience (1995-present); Journal of Comparative Neurology (2004-2007; 2012-2016); Journal of Chemical Neuroanatomy (2005-present); Brain Structure and Function (2006-present)
Society for Neuroscience
International Brain Research Organization