Jane McHowat, Ph.D.

Professor
Pathology
Research


Education

Ph.D, Bath University, 1988

Research Interests

Please see lab website for information

Publications

PubMed Listing

Rastogi, P., McHowat, J. Inhibition of calcium independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium.  Resp. Physiol. Neurobiol.  2009; 165, 167-174 PMC2845306

Sharma, J., Rastogi, P., Creer, M.H., McHowat, J. Polymorphonuclear leukocytes isolated from umbilical cord blood are a useful research tool to study adherence to cell monolayers, J. Immunol. Methods 2009; 351, 30-35  PMC2783264

Rastogi, P., Sharma, J., McHowat, J. Methods for measuring the activity and expression of phospholipases A2.  In:  Methods in Lipid-Mediated Signaling.  Murphy E & Rosenberger T (eds)  Taylor & Francis. 2010; pages 4-26

Sharma, J., Turk, J., McHowat, J. Endothelial cell prostaglandin I2 and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A2β knockout mouse.  Biochemistry, 2010; 49, 5473-5481  PMC2938187

Rastogi, P., Rickard, A., Klumpp, D.J., McHowat, J. Urothelial cell platelet-activating factor production is mediated via calcium-independent phospholipase A2γ.  Urology. 2011; 77, 248.e1-7.

Sharma, J., Turk, J., Mancuso D.J., Sims, H.F., Gross, R.W., McHowat, J. Activation of group VI phospholipase A2 isoforms in cardiac endothelial cells of wild type and knockout mice.  Am J Physiol Cell Physiol. 2011; 300, C872-C879.  PMID: 21191104

McHowat, J., Gullickson G., Hoover, R.G., Sharma J., Turk, J., Kornbluth J.  Platelet-activating factor and metastasis:  Calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung.  Am J Physiol Cell Physiol. 2011; 300,C825-C832  PMID:21228317

Sharma, J., McHowat, J. PGE2 release from tryptase-stimulated rabbit ventricular myocytes is mediated by calcium-independent phospholipase A2γ, Lipids, 2011; 46, 391-397. PMID:21461868

Blum, J., Kinsey, G.R., Monian, P., Sun, B., Cummings, B.S., McHowat, J., Schnellmann, R.G.  Profiling of Fatty Acids Released During Calcium-induced Mitochondrial Permeability Transition in Isolated Rabbit Kidney Cortex Mitochondria.  Toxicol In Vitro. 2011; 25. 1001-6. PMID: 21443943

Honors and Awards

De Montfort University, B. Sc. (First Class Honors) Pharmacy
University of Bath, Ph. D. Pharmacology    
1984-1987  Science and Engineering Research Council Predoctoral Fellowship
1991-1993  American Heart Association, Missouri Affiliate Postdoctoral Fellowship
1996-2000  Public Health Service, NHLBI FIRST Award
2011 Fellow of the American Heart Association

Professional Organizations and Associations

Fellow of the American Heart Association
American Physiological Society