Division of Pediatric Infectious Disease

Saint Louis University's Division of Pediatric Infectious Disease provides state-of-the-art care to pediatric patients with acute and chronic infectious diseases, educates medical students, residents, and community physicians on the latest advances in the field, and performs leading edge research.

Treatment is offered for all varieties of pediatric infectious disease problems for patients ranging in age from the newborns to young adults.

Pediatric Infectious Disease Training

Our division conducts basic science lectures to first and second-year medical students, introductory clinical lectures to third-year students and a consult service elective for fourth-year medical students. Faculty members also provide a monthly lecture for the Resident Lecture series and one or two residents per month rotate on the Pediatric Infectious Diseases consult service elective.

Clinical Activities

The Division of Pediatric Infectious Disease is almost exclusively a consulting service and does not have an inpatient pediatric service. We consult on approximately 350 children per year as inpatients and approximately 250 children per year as outpatients.

Aaron Miller, M.D. is responsible for the initial evaluation and continuing care of patients who are exposed to or infected with HIV. As a result, outpatient visits for the initial and follow-up evaluation of this patient population has increased.

Research

Division Research Projects

  •  Grant No: NIH R01 AI 081887 5/01/11-4/30/17
    PI: Stephen J. Barenkamp, M.D.
    Title: Development of a vaccine for prevention of Haemophilus influenzae otitis media
    Goals: The goals of this project are to characterize the human immune response to the HMW and Hia proteins following NTHi infection, to map the protective epitopes on these proteins, and to assess the protective potential of HMW-and Hia-based vaccines in an animal model of otitis media

Division Extramural Academic Activities

  • NIH Study Section Member: VMD 2013-2017
  • Editorial Advisory Board: Journal of Infectious Diseases, Clinical and Vaccine Immunology, Infection and Immunity
  • Journal referees: Clinical Infectious Diseases, Journal of Infectious Diseases, Journal of the Pediatric Infectious Diseases Society, New England Journal of Medicine, Pediatric Infectious Disease Journal, Pediatrics, PLoS One, PLoS Pathogens, Vaccine

Publications

Edwin L. Anderson, M.D.
  • Halasa NB, Gerber MA, Berry AA, Anderson EL, Winokur P, Keyserling H, Eckard AR, Hill H, Wolff MC, McNeal MM, Edwards KM, Bernstein DI. Safety and immunogenicity of full-dose trivalent inactivated influenza vaccine compared with half-dose TIV administered to children 6 through 35 months of age. J Pediatr Inf Dis Soc 4:214-224, 2015.
  • Frey SE, Wald A, Edupuganti S, Jackson LA, Stapleton JT, El Sahly H, El-Kamary SS, Edwards K, Keyserling H, Winokur P, Keitel W, Hill H, Goll JB, Anderson EL, Graham IL, Johnston C, Mulligan M, Rouphael N, Atmar R, Patel S, Chen W, Kotloff K, Creech CB, Chaplin P, Belshe RB. Comparison of lyophilized vs liquid modified vaccinia Ankara formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects. Vaccine 33:5225-5234, 2015.
  • Jackson LA, Frey SE, Sahly HM, Mulligan MJ, Winokur PL, Kotloff KL, Campbell JD, Atmar RL, Graham I, Anderson EJ, Anderson EL, Patel SM, Fields C, Keitel W, Rouphael N, Hill H, Goll JB. Safety and immunogenicity of a modified vaccinia Ankara vaccine using three immunization schedules and two modes of delivery: A randomized clinical non-inferiority trial. Vaccine 35:1675-1682, 2017.
 
Stephen J. Barenkamp, M.D.
  • Lin J, Haridas S, Barenkamp S, Lorenset LC, Sang Eun Lee A, Schroeder BT, Peng G. Koenig JM. Neonatal Neutrophils Stimulated by Group B Streptococcus Induce a Pro-Inflammatory T Helper Cell Bias. Pediatric Research, NIHMS913931, Oct 2017.
  • Winter LE, Barenkamp SJ. Immunogenicity of Nontypeable Haemophilus influenzae Outer Membrane Vesicles and Protective Ability in the Chinchilla Model of Otitis Media. American Society for Microbiology Clinical and Vaccine Immunology, October 2017, Vol. 24, Issue 10, e00138-17.
  • Barenkamp SJ, Chonmaitree T, Hakansson AP, et al. Report of the microbiology panel. Eighteenth International Otitis Media Research Conference. Otolaryngol Head Neck Surg 156:S51-S62, 2017
  • Pettigrew MM, Alderson MR, Bakaletz LO, Barenkamp SJ, et al. Report of the vaccines panel. Eighteenth International Otitis Media Research Conference. Otolaryngol Head Neck Surg 156:S76-S87, 2017.
  • Winter LE, Barenkamp SJ. Naturally-acquired HMW1/HMW2-specific serum antibodies in adults and children mediate opsonophagocytic killing of nontypeable Haemophilus influenzae. Clin Vaccine Immunol 23:37-46, 2016. PMC4711089.3.
  • Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Brockman KL, Clark TA, Biotano M, Power PM, Jen FE, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP. A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae. Nature Commun 6:7828, 2015. PMC4525171.
  • Atack JM, Winter LE, Jurcisek JA, Bakaletz LO, Barenkamp SJ, Jennings MP. Selection and counter-selection of Hia expression reveals a key role for phase-variable expression of this adhesion in infection caused by non-typeable Haemophilus influenzae. J Infect Dis 212:645-653, 2015. PMC4539897.
  • Barenkamp SJ. Editorial commentary: Respiratory viruses and otitis media in young children. Clin Infect Dis 60:10-11, 2015.
Aaron S. Miller, M.D.

 

  • Miller AS, Bennett J. Challenges in the care of young infants with suspected neonatal herpes simplex virus. Hospital Pediatrics 5:106-8, 2015.
  • Miller AS, Hall LE, Jones KM, Le C, El Feghaly RE. Afebrile Infants Evaluated in the Emergency Department for Serious Bacterial Infection. Pediatric Emergency Care. 2015 Sep 23. [Epub ahead of print].
  • Ahmad FA, Storch GA, Miller AS. Impact of an Institutional Guideline on the Care of Neonates at Risk for Herpes Simplex Virus in the Emergency Department. Pediatric Emergency Care. 2015 Aug 21. [Epub ahead of print]
  • Curfman AL, Glissmeyer EW, Ahmad FA, Korgenski EK, Blaschke AJ, Byington CL, Miller AS. Initial Presentation of Neonatal Herpes Simplex Virus Infection. Journal of Pediatrics. 2016 Mar 5. [Epub ahead of print]. PMID: 26960921
  • Peterson R, Miller AS. Varicella Zoster Virus Infection in Neonates. NeoReviews. September 2016, VOLUME 17 / ISSUE 9
Invited Publications

 

Miller, A.S., Orscheln R.C., Storch, G.A. "Outpatient Antibiotics and Emerging Antimicrobial Resistance." Pediatric UPDATE. 2014; 34 (10).

Book Chapters
  • Peterson R, Miller AS. Varicella zoster virus infection in neonates. NeoReviews 17:e507-e514, 2016.
  • Miller AS. Transfer of children with infectious diseases. In Insoft R, Schwartz H, Romito J (eds): Guidelines for Air and Ground Transport of Neonatal and Pediatric Patients. American Academy of Pediatrics Section on Transport Medicine, 5th Ed, [In press].
  • Barenkamp SJ. Haemophilus influenzae. In: Cherry JD, Harrison GJ, Kaplan SL, et al. (eds): Textbook of Pediatric Infectious Diseases, 8th ed., Philadelphia, Elsevier, [In press].
  • Barenkamp SJ. Other Haemophilus species (Ducreyi, Haemolyticus, Influenzae Biogroup Aegyptius, Parahaemolyticus, and Parainfluenzae) and Aggregatibacter (Haemophilus) aphrophilus. In: Cherry JD, Harrison GJ, Kaplan SL, et al. (eds): Textbook of Pediatric Infectious Diseases, 8th ed., Philadelphia, Elsevier, [In press].
Presentations at National Meetings

Stephen J. Barenkamp, M.D.

  • The following talk was given at the Annual Meeting of the Pediatric Academic Societies in Baltimore, MD on May 1, 2016 as a Platform Presentation: Winter LE, Barenkamp SJ. Nontypeable Haemophilus influenzae HMW1/HMW2 proteins and outer membrane vesicles induce broadly cross-reactive antibodies capable of mediating opsonophagocytic killing.
 
Abstracts

Aaron S. Miller, MD

  • Curfman A, Glissmeyer E, Ahmad F, Korgenski E, Blaschke A, Byington C, Miller A. Initial Presentation of Neonatal Herpes Simplex Virus Infection. IDWeek National Meeting, 2015.
  • Concomitant Bacterial Meningitis in Infants With Urinary Tract Infection. Thomson J, Cruz A, Nigrovic L, Freedman S, Garro A, Ishimine P, Kulik D, Uspal N, Grether-Jones K, Miller AS, Shah SS, for the PEM-CRC HSV Study Group. Abstract presented at the Pediatric Academic Society National Meeting, May 1st, 2016.
  • HSV in infants <= 60 days presenting for emergency department evaluation. Cruz A, Freedman S, Kulik D, Fleming A, Thomson J, Schnadower D, Garro A, Pruitt C, Balamuth F, Aronson P, Uspal N, Lyons T, Ishimine.