Division of Pediatric Nephrology

The Division of Pediatric Nephrology in the Department of Pediatrics of Saint Louis University provides comprehensive care for infants, children and adolescents with various forms of kidney or urologic disorders, both acute and chronic.

Members of the division are involved in the teaching of medical students, residents, community physicians and families and participate in various clinical research studies. The division is housed at SSM Health Cardinal Glennon Children’s Hospital. Our multidisciplinary team includes physicians, renal nurses, a renal dietitian, a renal social worker and a play therapist. 

Medical Education 

Our educational programs address training of pediatric residents, family practice residents, and medical students, as well as community programs for families of children with renal disease and continuing medical education (CME) activities for community physicians.

Transplant and Clinical Services

Our division began a renal transplant program in 1983. Since that time, approximately 150 pediatric renal transplants have been performed. The division currently follows approximately 45 renal transplant recipients. Deceased donor, living related, and living unrelated renal transplants are currently performed. We also participate in kidney paired donation (KPD), the donor exchange program for living donors.

The division provides primary management of renal transplant recipients along with members of the transplant surgery service. We also provide fetal consultation through the Fetal Care Institute.

Hypertension

Our division has a special interest in hypertension, with a weekly clinic for patients with primary hypertension, and an active Ambulatory BP monitoring program. A bi-monthly outreach clinic is held at an outpatient facility in the southern suburbs of St. Louis. 

The division has a formal transition program for dialysis and transplant patients to aid in the successful transition to adult care.

Clinical Services Overview

Our physician faculty members treat  a variety of acute and chronic kidney disorders, including congenital and hereditary disorders involving the kidney and urinary tract, urinary tract infections, kidney stones, hypertension, acute and chronic glomerular and tubular disorders and renal diseases that occur secondary to a variety of systemic diseases, such as systemic lupus erythematosus, diabetes mellitus, and vasculitis.

Learn About Services Offered and Our Clinical Practice 

Research

The division participates in the North American Pediatric Renal Transplant Cooperative Study, a registry for Transplant, Dialysis, and Chronic Renal Insufficiency patients. We also participate in multi-center studies  funded by the NIH and the  Midwest Pediatric Nephrology Consortium Study Group, as well as in pharmaceutical studies.

Division director Craig Belsha, M.D., serves on the Medical Advisory Panel for the Atypical HUS Foundation, which has been active in funding research studies related to this devastating disease.

Current Research

Multi-Center NIH studies:

  • Chronic Kidney Disease in Children (CKID study) (Wood E: Center PI)
  • Cure GN: Cure Glomerulonephropathy Network, a sub-award of “Integrative Proteomics and Metabolomics for Pediatric glomerular Disease Biomarkers” (Belsha CW: Center PI)

Pharmaceutical Multi-Center Studies

  • A Randomized, Double- Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Cinacalcet HCL in Pediatric Subjects with Chronic Kidney Disease and Secondary Hyperparathyroidism Receiving Dialysis. Sponsored by Amgen. (Wood EG: center PI)

Midwest Pediatric Nephrology Consortium Study Group Multi-Center Study

  • Outcomes of Permanent Vascular Access in Pediatric Hemodialysis Patients. (Wood EG: center PI, Co- PI for study)

Independent Studies

  • Study with Fetal Care Institute: Proof of Concept: Identifying Genetic Causes of Congenital Renal Disease. (Feldenberg, LR)

Grants

  • NIH-NIDDK
    E.Wood, M.D. – PI at St. Louis University
    CKID Study - Multi-Center Study
  • NIH-NIDDK
    C.W. Belsha, M.D. – PI at St. Louis University
    Cure GN: Cure Glomerulonephropathy Network, a sub-award of “Integrative Proteomics & Metabolomics for Pediatric Glomerular Disease Biomarkers”.
  • Amgen
    E. Wood, M.D. – PI at St. Louis University
    A Randomized, Double- Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Cinacalcet HCL in Pediatric Subjects with Chronic Kidney Disease and Secondary Hyperparathyroidism Receiving Dialysis.
  • SSM St. Mary’s Health Center Foundation
    LR Feldenberg, M.D.- Co-investigator
    Proof of Concept: Identifying Genetic Causes of Congenital Renal Disease.

Publications

  • Wen JX, Feldenberg LR, Abraham E, Sadiq F, Christensen KM, Braddock SR. Continuous venovenous hemodialysis via extracorporeal membrane oxygenation pump for treatment of hyperammonemia secondary to propionic acidemia in monochorionic diamniotic twin boys. J Pediatr June 6 2016.

Presentations

  • Beck, A: “Fluids and Electrolytes, Nephrotic syndrome, AGN, UTI, Congenital uropathies, Hypertension” at Osler Institute Board Review Course, 2016
  • Belsha CW: “Assessment of Renal Function in CKD” at American Nephrology Nurses Association, St. Louis Chapter, October 2015
  • Feldenberg LR: “Pediatric Kidney Transplantation” at Adventures in Medicine (AIMs) summer program for High School students with interest in studying medicine, June 2016.
  • Onder AM, Wood E, Billings AA, Eng F, Defreitas M, Katsoufis CP, Flynn JT. Complications and outcomes of permanent vascular access (PVA) in pediatric hemodialysis patients: A MWPNC study. Poster presentation #1474. 176; American Society of Pediatric Nephrology Meeting, May 2016