14-002- Antibody-based therapeutics for the treatment of diabetes complications

Category: Therapeutic

Inventors: Gina L. C. Yosten, Ph.D., Grant R. Kolar, M.D., Ph.D.

Summary: This invention is a humanized antibody or combination of antibodies directed against one or more extracellular domains of the proinsulin C-peptide, GPR146. These antibodies may serve as a C-peptide sensitizer, enhancing C-peptide signaling and activity. This could forestall or reverse diabetes-associated microvascular dysfunction, which can lead to blindness, kidney disease, in loss of feeling or function in the limbs and lead to amputation.

Patent: U.S. patent application 14/862,088