Phone: (314) 977-7656
Fax: (314) 977-3658
Mail: Department of Biology, St. Louis University, 3507 Laclede Ave. St. Louis, MO 63103-2010
Courses: Foundations of Immunobiology, Concepts of Immunobiology, Principles of Biology I
Research Interests: There are two main areas of research in my lab.The first project is to explore the neonatal immune response to respiratory viral infection. Infants are especially vulnerable to viral infections. This is due, in part, to an immature immune system. My laboratory uses a mouse model of viral infection to elucidate the cellular and molecular differences between the neonatal and adult immune response to viral infection. We are also interested in how immune factors in maternal milk may modulate the neonatal immune response.
The second research project is aimed at understanding why wound healing is impaired in diabetic patients. Delayed wound healing in diabetic patients results in many amputations, and has a significant effect on the quality of life for these patients. We are examining the differences in immune cell activation during the course of normal and diabetic wound healing.
I welcome graduate and undergraduate students interested in immunology. Students will learn basic laboratory skills including laboratory safety, how to keep a lab notebook, making solutions, pipetting, and sterile technique. There are opportunities to learn molecular biology and immunological techniques including viral propagation, cell culture, flow cytometry, immunohistochemical staining, ELISA, PCR, nucleic acid hybridization. Lab meetings are held to discuss data & future experiments, journal articles & lab management issues.
Maternal inflammation modulates infant immune response patterns to viral lung challenge in a murine model. Gleditsch DD, Shornick LP, Van Steenwinckel J, Gressens P, Weisert RP, Koenig JM. Pediatr Res. 2014 Apr 11. doi: 10.1038/pr.2014.57. [Epub ahead of print]
Pillars article: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994. 264: 703-707.
De Togni P, Goellner J, Ruddle NH, Streeter PR, Andrea F, Mariathasan S, Smith SC, Carlson R, Shornick LP, Strauss-Schoenberger J, Russell JH, Karr R, Chaplin DD.
J Immunol. 2014 Mar 1;192(5):2010-4.
Silver dressings improve diabetic wound healing without reducing bioburden. Finley, P.J., Huckfeldt, R.E., Walker, K.D., Shornick, L.P. Wounds Volume 25, Issue 10, October 2013, Pages 293-301.
Bhattacharya, S., Beal, B.T., Janowski, AM, Shornick, L.P. (2011) Reduced inflammation and altered innate response in neonates during paramyxoviral infection. Virology Journal 8(1):549.
Anbukumar D.S., Shornick L.P., Albert C.J., Steward M.M., Zoeller R.A., Neumann W.L., Ford D.A. (2010) Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal. J Lipid Res. 51(5):1085-92.
Shornick, L.P., Zhang, Y., Huang, G., Sosa, M., Shukla, N., Agapov, E., Holtzman, M.J. (2008) Airway Epithelial versus Immune Cell Stat1 Function for Innate Defense against Respiratory Viral Infections. Journal of Immunol., 180(5):3319-28.
Zhang, Y., Huang, G., Shornick, L.P., Roswit, W.T., Brody, S.L. Holtzman, M.J. (2007) Transgenic FoxJI-Cre mediates recombination in ciliated cells. Am. J. Resp. Cell & Molec. Biol., 36(5):515-519.
Deppong, C., Juehne, T.I., Hurchla, M., Friend, L.D., Shah, D.D., Rose, C.M., Bricker, T.L., Shornick, L.P., Crouch, E.C., Murphy, T.L., Holtzman, M.J., Murphy, K.M., Green, J.M. (2006) BTLA and PD-1 Inhibitory Receptors are Required for Termination of Acute Allergic Airway Inflammation. J. Immunol., 176 (7): 3909-13.
Holtzman M.J., Tyner J.W., Kim E.Y., Lo M.S., Patel A.C., Shornick L.P., Agapov E., Zhang Y. (2005) Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2(2):132-40.
Holtzman M.J., Kim E.Y., Lo M.S., Tyner J.W., Shornick L.P., Sumino K.C., Zhang Y. (2005) Defining and adjusting divergent host responses to viral infection. Immunol Res. 32:123-42.
Holtzman, M.J., Shornick, L.P., Grayson, M.H., Kim, E.Y., Tyner, J.W., Patel, A.C., Agapov, E., Zhang, Y. (2004) Hit-and-run effects of paramyxoviruses as a basis for chronic airway disease. Ped. Infect. Dis. J., 23:S235-45.
Verbsky, J.W., Randolph, D. A., Shornick, L.P., Chaplin, D.D. (2002) Non-hematopoietic expression of Janus Kinase 3 is required for efficient recruitment of Th2 lymphocytes and eosinophils in OVA-induced airway inflammation. J. Immunol. 168:2475-2482.
Holtzman, M.J., Morton, J.D., Shornick, L.P., Tyner, J.W., O'Sullivan, M.P., Antao, A., Lo, M., Castro, M. and Walter, M.J. (2002) Immunity, Inflammation, and Remodeling in the Airway Epithelial Barrier: Epithelial-Viral-Allergic Paradigm. Physiol. Rev. 82:19-46.
Shornick, L.P., Bisarya, A.K, Chaplin, D. D. (2001) IL-1beta is essential for Langerhans cell activation and antigen delivery to the lymph nodes during contact sensitization: evidence for a dermal source of IL-1beta, Cellular Immunol. 211:105-112.
Shornick, L.P., De Togni, P., Mariathasan, S., Goellner, J., Strauss-Schoenberger, J., Karr, R., Ferguson, T., Chaplin, D. D. (1996) Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzene. J. Exp. Med. 183: 1427-1436.
De Togni, P., Goellner, J., Ruddle, N.H., Streeter, P.R., Fick, A., Mariathasan, S., Carlson, R., Shornick, L.P., Strauss-Schoenberger, J., Russell, J. H., Karr, R., and Chaplin, D. D. (1994) Abnormal development of peripheral lymphoid organs in lymphotoxin deficient mice. Science 264: 703-707.
Hussain, H., Shornick, L.P., Shannon, V.R., Wilson, J.D., Funk, C.D., Pentland, A.P. and Holtzman, M.J. (1994) Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. Am. J. Physiol. 266:C243-C253.
Shornick, L.P. and Holtzman, M.J. (1993) A cryptic, microsomal-type arachidonate 12-lipoxygenase is tonically inactivated by oxidation-reduction conditions in cultured epithelial cells. J. Biol. Chem. 268:371-376.
Holtzman, M.J., Turk, J., Shornick, L.P. (1992) Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells. J. Biol. Chem. 267: 21438-21445.