- Technology Management
- For Industry - Technology Available for Licensing
- Contact Technology Management
- old pages
- title page
- A Modern Approach to Wing Warp for Aircraft Control
- Treatment Of Liver Fibrosis Following Hepatic Injury By Selective Killing Of Activated Liver Stellate Cells
- Compositions and Methods for Treating and Diagnosing Hepatoma
- Vaccine Compositions and Methods That Increase Safety of Anti-Viral Vaccination Without Loss of Efficacy
- Automatic Pressure-Locking Valve Prevents CSF Loss and Herniation During Lumbar Puncture When Intracranial Pressure Is Elevated.
- Immortal Differentiated Type II Lung Epithelial Cell Line (T7)
- Human A Rapid, Reliable Bedside Diagnostic Method For Accurately Determining Feeding Tube Placement In Respiratory Tract, Stomach, Or Small Bowel Of Patients Prior to Enteral Nutrient Administration.
- Human Natural Killer Cell Line - NK 3.3:
- Factor IXa Protease Helix-330 (Region 1)
- In Vitro Method for Concerted Integration of Donor DNA Molecules Into Target DNA Using Retroviral Integrase and a Procedure for Evaluation of Donor DNA Integration.
- SRCAP: A Novel Transcription Protein Having Therapeutic Target and Diagnostic Target Product Development Potential.
- C-Terminal Binding Protein Interacting Protein (CtIP):
- Novel Anti-Coagulation Therapeutics: Agents That Effectively Inhibit Binding of Factor VIIIa (Region 3) With Factor IXa (Region 2) Without Activating Factor X.
- Genetically Modified Activated Protein C with Reduced Anticoagulant Properties
- C22: A Conditionally Immortalized Mouse Clara Cell Line
Automatic Pressure-Locking Valve Prevents CSF Loss and Herniation During Lumbar Puncture When Intracranial Pressure Is Elevated.
Inventors: Enrique C. Leira, M.D. and Sridhar Condoor, Ph.D.
Lumbar puncture (LP) is a potentially hazardous procedure when the cerebrospinal fluid (CSF) pressure is above normal. Computerized tomography (CT) does not always permit a physician to anticipate the existence of elevated intracranial pressure. A simple pressure-locking valve, which attaches to the opening of a LP needle has been developed and demonstrated to block inappropriate loss of CSF in the event that intracranial pressure is excessive.
When intracranial pressure at the LP needle opening exceeds the pre-designed 200mm of water pressure-lock level, the piston in the pressure-locking valve translates thereby blocking the exit port and preventing excessive loss of CSF and herniation that can be caused by rapid release of elevated intracranial pressure. In laboratory studies with animals, the automatic pressure-locking valve routinely and rapidly responded to elevated hydrostatic pressure (> 200 mm of water) by blocking the outflow of fluid within 0.5-1 second.
Use of this simple pressure-locking valve during lumbar puncture could improve the safety of LP in certain clinical situations that are associated with high intracranial pressure and increased risk of excessive CSF loss and herniation such as in cases of bacterial meningitis and when CT neuro-imaging is unavailable.
Prevention of CSF loss and herniation due to elevated intracranial pressure during lumbar puncture.
Category: Medical Device
Keywords: Cerebral spinal fluid, CSF, lumbar puncture, LP, herniation, intracranial pressure, meningitis, CT scan.
Reference Number: SLU 00-013