Lulin Hu, M.D., Ph.D., resident in pathology, will present at "Topics in Pathology" noon Monday, Jan. 14, in Pitlyk Auditorium C of the Learning Resources Center. His topic is "The Application of p16 Expression in Cervical Pap Smear and Biopsy."
|Lulin Hu, M.D., Ph.D.|
|After HPV infection, HPV E7 binds to Rb protein and leads to pRb degradation, releasing E2F from the pRb-E2F complex. E2F activates the cell cycle. Disruption of the pRb-E2F complex by E7 also releases the p16 gene from its negative feedback control, resulting in p16 overexpression. Since pRb is degraded and E2F is unbound, p16 no longer has an inhibitory function on pRb and cannot inhibit the cell cycle. p16 expression in cervical intraepithelial neoplasia and its relation to high-risk HPV infection in adolescents has not been reported.|