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Alexei V. Demchenko, Ph.D.

Professor; Department Chair
Chemistry


Education

M.S. in Chemical Engineering, Mendeleev University of Chemical Technology of Russia, 1988
Ph.D. in Organic Chemistry, Zelinsky Institute of Organic Chemistry, Russia, 1993

Research Interests

Chemical glycosylation, Oligosaccharide assembly, Biomedical applications, Innovative technologies

Publications and Media Placements

  • S. Escopy, Y. Singh, K. J. Stine, and A. V. Demchenko.  A Streamlined regenerative glycosylation reaction: direct, acid-free activation of thioglycosides.  Chem. Eur. J., 2021, 27, 354-361;  https://doi.org/10.1002/chem.202003479 
  • M. Shadrick, Y. Singh, and A. V. Demchenko.  Stereocontrolled α-galactosylation under cooperative catalysis.  J. Org. Chem., 2020, 85, 15936-15944;  https://dx.doi.org/10.1021/acs.joc.0c01279
  • G. Shrestha, M. Panza, Y. Singh, N. P. Rath, and A. V. Demchenko.  Indolylthio glycosides as effective building blocks for chemical glycosylation.  J. Org. Chem., 2020, 85, 15885-15894; https://doi.org/10.1021/acs.joc.0c00943
  • M. Panza, D. Neupane, K. J. Stine, and A. V. Demchenko.  The development of a dedicated polymer support for the solid-phase oligosaccharide synthesis.  Chem. Commun., 2020, 56, 10568-10571; https://doi.org/10.1039/D0CC03885G
  • S. A. Geringer, Y. Singh, D. J. Hoard, and A. V. Demchenko.  A highly efficient glycosidation of glycosyl chlorides using cooperative silver(I) oxide - triflic acid catalysis.  Chem. Eur. J., 2020, 26, 8053-8063; https://doi.org/10.1002/chem.201905576
  • M. P. Mannino and A. V. Demchenko.  Synthesis of β-glucosides with 3-O-picoloyl-protected glycosyl donors in the presence of excess triflic acid: defining the scope.  Chem. Eur. J., 2020, 26, 2938-2946; https://doi.org/10.1002/chem.201905278 
  • M. D. Bandara, K. J. Stine, and A. V. Demchenko.  Chemical synthesis of human milk oligosaccharides: lacto-N-neohexaose [Galβ1®4GlcNAcβ1®]2 3,6-Galβ1®4Glc.  Org. Biomol. Chem., 2020, 18, 1747-1753; https://doi.org/10.1039/D0OB00172D
  • M. P. Mannino and A. V. Demchenko.  Synthesis of β-glucosides with 3-O-picoloyl-protected glycosyl donors in the presence of excess triflic acid: a mechanistic study.  Chem. Eur. J., 2020, 26, 2927-2937;  https://doi.org/10.1002/chem.201905277
  • M. Panza, K. J. Stine, and A. V. Demchenko.  HPLC-assisted automated oligosaccharide synthesis: the implementation of the two-way split valve as a mode of complete automation.  Chem. Commun., 2020, 56, 1333-1336; https://doi.org/10.1039/C9CC08876H
  • Y. Singh and A. V. Demchenko.  Defining the scope of the acid-catalyzed glycosidation of glycosyl bromides.  Chem. Eur. J., 2020, 26, 1042-1051; https://doi.org/10.1002/chem.201904185
BOOKS EDITED

  • Handbook of Chemical Glycosylation, A. V. Demchenko Ed., Wiley-VCH, 2008
  • Frontiers in Modern Carbohydrate Chemistry, A. V. Demchenko Ed., ACS Symp. Ser., 960, 2007

Honors and Awards

  • Co-Investigators of the Year Award (with K. J. Stine), UM – St. Louis Office of Research (2020)
  • Outstanding Scientists Awards - Fellows Award, Academy of Science - St. Louis (2020)
  • Senior Investigator of the Year Award, UM – St. Louis Office of Research (2017)
  • American Chemical Society St. Louis Award (2014)
  • Chancellor’s Award for Excellence in Research and Creativity, UM – St. Louis (2013)
  • Mizutani Foundation for Glycoscience Award (2013)
  • New Investigator Award, American Chemical Society, Division of Carbohydrate Chemistry (2007)
  • CAREER Award, National Science Foundation (2005)

Professional Organizations and Associations

  • Fellow of the Academy of Science – St. Louis (2020)
  • Chair, Division of Carbohydrate Chemistry, American Chemical Society (2020-2021)
  • The National Representative of the USA for the International Carbohydrate Organization (2019)
  • President of the U.S. Advisory Committee for the International Carbohydrate Symposia (2019)
  • Chair, Gordon Research Conference on Carbohydrates (2015)
  • Associate Editor, Journal of Carbohydrate Chemistry (2012-2021)