R. Scott Martin, Ph.D.
Department Chair; Professor
Department of Chemistry
B.S. in Chemistry, Southwest Missouri State University, 1994
M.S. in Chemistry, Southwest Missouri State University, 1996
Ph.D. in Analytical Chemistry, The University of Missouri - Columbia, 1999
NIH Post-Doctoral Fellow, University of Kansas, 1999-2002
Research in the Martin group has been focused on using microchip technology to study cellular systems in a manner where an analysis scheme can be integrated to study the release of neurotransmitters in close to real time. We feel that this approach will allow us to use in vitro models to study the processes that lead to disease onset by studying cell-to-cell interaction on a molecular level and in a quantitative fashion. This research has led the group to publish many papers in this area including descriptions of advancements in microchip valving technology, the integration of electrochemical detection with microchip electrophoresis, the discovery of embedded electrodes in microchip devices for the sensitive and selective detection of nitric oxide (NO), and the development of new methods for immobilizing cells (endothelial and PC 12 cells) in microfluidic devices. In addition, the group has developed methods to quantitate the amount of ATP release directly from erythrocytes when they are mechanically deformed as well as methods of rapidly measuring intracellular glutathione concentrations. We continue to work at the forefront of this exciting area, with our recent emphasis being on developing more robust cell culture on-chip to enable cell-to-cell communication studies. Students in the group receive a broad base of training in analytical chemistry as well as biology and engineering.
Labs and Facilities
Publications and Media Placements
Selected publications (from 64 publications at SLU):
1. B.T. Mehl and R.S. Martin, "Integrating 3D cell culture of PC12 cells with microchip-based electrochemical detection," Analytical Methods, 2019, 11, 1064-1072.
2. A.D. Townsend, R. S. Sprague, and R.S. Martin, "Microfluidic Device Using a Gold Pillar Array and Integrated Electrodes for On-chip Endothelial Cell Immobilization, Direct RBC Contact, and Amperometric Detection of Nitric Oxide, Electroanalysis, 2019, 31, 1409–1415.
3. A. D. Castiaux, C. W. Pinger, E. A. Hayter, M. E. Bunn, R. S. Martin and D. M. Spence, Analytical Chemistry, 2019, 91, 6910-6917.
4. A.D. Castiaux, D. M. Spence, R.S. Martin, "Review of 3D cell culture with analysis in microfluidic systems," Analytical Methods 2019, 11, 4220-4232.
Honors and Awards
1. AES Mid-Career Award, presented at SciX 2017 in Reno, NV
2. Associate Editor for Analytical Methods (RSC journal), 2013-2017
3. Fellow, Royal Society of Chemistry (2014-present)
4. College of Arts and Sciences Endowed Professor of Chemistry, July 2011 - 2015
5. Graduate Mentor Award, Saint Louis University Graduate Student Association, 2011 (presented at the Arts and Sciences Pre-Commencement)
6. Secondary appointment in Department of Pharmacological & Physiological Science, Saint Louis University, 2010-present
7. Co-chair of 65th Midwestern Universities Analytical Chemistry Conference (MUACC), scheduled to be on the Saint Louis University Campus in Fall of 2011 (attended by ~100 faculty from Midwest Universities)
8. Associate Program Chair for LabAutomation 2008 and Program Chair for LabAutomation 2009.
Professional Organizations and Associations
Editor in Chief, Analytical Methods (a RSC journal)