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RSV Vaccine Trial Collaboration for the Smallest Patients

Vaccine Trial

Heidi Sallee, M.D., associate professor, and Mary Susan Heaney, M.D., professor in the Department of Pediatrics, Division of General Academic Pediatrics at Saint Louis University School of Medicine, are collaborating with Dr. Frey at the Center for Vaccine Development on a clinical trial to test the safety of a respiratory syncytial (RSV) vaccine.

While RSV is common and can cause mild cold-like symptoms, the respiratory virus can also be serious—especially for infants and small children with underlying respiratory conditions. The development of a vaccine would be significant because RSV is the most common cause of bronchiolitis and pneumonia in children younger than one. Of note, almost all children will be infected with RSV by the time they are two.

Heidi Sallee
Heidi Sallee, M.D., Associate Professor, Department of Pediatrics

Drs. Sallee, Heaney and the SLUCare Physician Group at Cardinal Glennon Children’s Hospital as part of a multicenter trial, are working to recruit a total of 160 patients across all sites to test three mucosal vaccines, as well as one placebo—40 participants in each arm of the trial. SLUCare Physician Group at Cardinal Glennon Children’s Hospital is one of the sites selected to be part of the RSV clinical trial due to its significant patient volume, and commitment to leading edge patient care and health literacy.

Finding qualified trial candidates can be a challenge. Patients must be between 6 and 24 months old and must be in good health. Additionally, patients must not have been exposed to RSV in the past and cannot not spend time with other children under 6 months of age for one month after exposure to the vaccine.

Mary Susan Heaney
Mary Susan Heaney, M.D., Professor, Department of Pediatrics

Drs. Sallee and Heaney, together with the team at the Center for Vaccine Development, are an integral part of the team of researchers and healthcare providers who are working to ensure the safety, efficacy, and creation of the next generation of vaccines. 

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