George L. Eliceiri, M.D., Ph.D.
M.D., University of Buenos Aires
Ph.D. in Biochemistry, University of Oklahoma
Signaling that modulates cancer cell invasion and migration. Both cell invasion and migration are required for cancer metastasis. We are interested in some signaling pathways that control invasion and migration, because this is important for molecular targeted cancer therapies, cancer chemoprevention, and to understand the regulation of cancer development. Our findings include the following. First, we detected many new specific signaling pathways from cancer regulators to cancer-modulating matrix metalloproteinases (MMPs), which differ widely in various cancer cells (2,3,5). Second, unexpectedly many of these signaling pathways specifically inhibit MMP gene expression in cells of some cancers, but stimulate it in others (2,3). Third, each of many proteins enhances invasiveness in cells of some cancers, but suppresses it in others (4). Fourth, almost all of the invasiveness-modulating proteins known to have experimentally verified activation, inhibition or binding interactions with each other are linked in a single network, in a “hub-and-spoke” architecture, as shown by bioinformatics analysis (4). Fifth, cell invasiveness is modulated by cancer cell MMPs whose gene expression levels are very low, and by MMPs not known to have this role (1).
Hegedüs L, Cho H, Xie X, Eliceiri, GL (2008) Additional MDA-MB-231 breast cancer cell matrix metalloproteinases promote invasiveness J. Cell. Physiol. 216:480-485.
DeLassus GS, Cho H, Park J, Eliceiri GL (2008) (PDF) New pathway links from cancer-progression determinants to gene expression of matrix metalloproteinases in breast cancer cells. J. Cell. Physiol. 217:739-744.
DeLassus GS, Cho H, Hoang S, Eliceiri GL (2010) Many new down- and up-regulatory signaling pathways, from known cancer progression suppressors to matrix metalloproteinases, differ widely in cells of various cancers. J. Cell. Physiol. 224:549-558. Erratum: J Cell Physiol 225:916 (2010)
Kan J S , DeLassus G S, D'Souza K G, Hoang S, Aurora R, Eliceiri GL (2010) Modulators of cancer cell invasiveness. J. Cell. Biochem. 111:791-796.
DeLassus GS, Cho H, Eliceiri GL (2011) New signaling pathways from cancer progression modulators to mRNA expression of matrix metalloproteinases in breast cancer cells J. Cell Physiol. 226:3378-3384
Selected Earlier Publications
Ruff, E.A., Rimoldi, O.J., Raghu, B., Eliceiri, G.L.(1993) Three small nucleolar RNAs of unique nucleotide sequences. Proc. Natl. Acad. Sci. USA 90:635-638 .
Rimoldi, O.J., Raghu, B., Nag, M.K., Eliceiri, G.L. (1993)Three new small nucleolar RNAs that are psolaren crosslinked in vivo to unique regions of pre-rRNA. Mol. Cell Biol. 13:4382-4390 .
Nag, M.K., Thai, T.T., Ruff, E.A., Selvamurugan, N., Kunnimalaiyaan, M., Eliceiri, G.L. (1993)Genes for E1, E2, and E3 small nucleolar RNAs. Proc. Natl. Acad. Sci. USA 90:9001-9005 .
Selvamurugan, N., Joost, O.H., Haas, E.S., Brown, J.W., Galvin, N.J., Eliceiri, G.L. (1997) Intracellular localization and unique conserved sequences of three small nucleolar RNAs. Nucleic Acids Res. 25:1591-1596 .
Mishra, R.K., Eliceiri, G.L. (1997) Three small nucleolar RNAs that are involved in ribosomal RNA precursor processing. Proc. Natl. Acad. Sci. USA 94:4972-4977 .
Eliceiri, G.L. (1999) Reversible depletion of specific RNAs by antisense oligodeoxynucleotide-targeted degradation in frog oocytes. Methods Enzymol. 313:436-442.
Eliceiri, G.L. (1999) Small nucleolar RNAs . Cell. Mol. Life Sci. 56:22-31.
Ruhl,D. D., Pusateri,M. E. and Eliceiri, G.L.(2000) Multiple conserved segments of E1 small nucleolar RNA are involved in the formation of a ribonucleoprotein particle in frog oocytes Biochem. J. 348, 517-524
Smith, J.L., Walton, A.H., Eliceiri, G.L.(2005) UV-crosslinking of E1 small nucleolar RNA to proteins in frog oocytes. J. Cell. Physiol. 203:202-208
Eliceiri, G.L. (2006)The vertebrate E1/U17 small nucleolar ribonucleoprotein particle. J. Cell. Biochem. 98:486–495.