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Ajay Jain, M.D.

Associate Professor
Pediatrics, Pharmacology and Physiology

Associate Division Chief: Pediatric Gastroenterology Hepatology and Nutrition; Medical Director: Pediatric Liver Transplantation, Saint Louis University, St. Louis


Education

Postgraduate Training: 

Postdoctoral Research: Baylor College of Medicine, Houston, TX, USA. 07/2007-06/2009 

Post Doctoral Clinical Fellow: Pediatric Gastroenterology, Hepatology 

and Nutrition, Baylor College of Medicine, Texas Children’s Hospital, 

Houston, TX, USA. 07/2006-06/2009 

Senior Research Fellow: Indian Council of Medical Research, 08/2001-07/2004 

Ansari Nagar, New Delhi, India. 

Pediatric Resident: Medical College of Georgia, Augusta, GA. 07/2004-06/2006 

Research Fellow, Indian Council of Medical Research (ICMR). 08/2001-07/2004 

Diplomate of National Board (DNB, India), Pediatrics 08/2001-07/2003 

Pediatric Resident: Maulana Azad Medical College, New Delhi, India 05/1999-04/2001 

House Officer, GB Pant Hospital, New Delhi, India 1998-1999 

Medical School: Maulana Azad Medical College, New Delhi, India 1992-1998

Publications and Media Placements

Research Support: 

Active Research  

1. NIH-1U01-DK61718, NIH NASH CRN Neuschwander-Tetri, PI 07/01/2011 – current 

Multicenter studies on the etiology, contributing factors, natural history, and treatment of nonalcoholic steatohepatitis (NASH) 

Site, Role: Saint Louis University, Co-Investigator 

 

2. Zealand Pharmaceuticals: Role of novel gut growth promoters in intestinal rehabilitation: April 2018-April 2019 

Role: Principal Investigator: Ajay Jain 

 

3. NIH K08DK098623-01A1: Role of the bile acid activated receptors FXR and TGR5 in Total Parenteral Nutrition associated hepatic and gut disease: 02/01/2016 - 02/01/2021 

Role: Principal Investigator: Ajay Jain 

 

4. Clinical Innovation Fund: Cytokeratin 18 as a bio-marker for rejection in liver transplantation. Mid America Transplant Foundation. 07/01/2018-06/30/2020 

Role: Principal Investigator: Ajay Jain 

 

5. Synageva (Lexington, MA): Industry Supported: 2014-2018 

‘Determination of Lysosomal Acid Lipase Activity and Cholesterol Ester Storage Disease Prevalence’ 

Site, Role: Principal Investigator: Ajay Jain 

 

6. Bill and Melinda Gates Foundation, Jain SK, PI, 11/01/2017 – 11/01/2018 

Grand Challenges Explorations, "Improving Childhood Immunizations with Cellular Technology" 

Site, Role: Saint Louis University, Co-Investigator 

 

7. DeNardo (Health Sciences) Education and Research Foundation: Heuertz R, PI, 2017-2018 

Active Learning Through Research. 

Site, Role: Saint Louis University, Co-Investigator 

 

8. Fleur-de-lis: Role of fecal transplantation in parenteral nutrition associated injury. 07/01/2018 – 06/30/2019. Role: Principal Investigator: Ajay Jain 

9 .Fleur-de-lis: Profiling the gut microbiome in individuals with Prader-Willi Syndrome, PI Whitman B 07/01/2017 – 06/30/2018 

Role: Co- Investigator: Ajay Jain 

 

10. CHEAR: The Children’s Health Exposure Analysis Resource (CHEAR) to develop a proposal for the study, 'Role of environmental toxicants in modulating disease severity in children with NAFLD'. 

Role: Principal Investigator: Ajay Jain 

 

11. NIH NIDDK: STOP-NAFLD trial, Losartan for the Treatment of Pediatric NAFLD: A Phase 2, Randomized, Placebo-Controlled Clinical Trial. Principal Investigator : Role: Principal Investigator: Ajay Jain 

 

12. SPLIT: Studies of Pediatric Liver Transplantation: SPLIT works to identify emerging trends in care, focusing on short and long term outcomes with a goal of gaining new knowledge that can be translated into changes in clinical practice. This research also generates new ideas for translational research/clinical trials which SPLIT actively pursues. 05/2013-Current 

Role: Principal Investigator: Ajay Jain. 

 

Completed Research 

 

1. NIH-1R03EB015955-01, Jain SK, PI, 09/30/2015 – 07/31/2017. Enhancing Health Care Access with Cellular Technology. Site, Role: Saint Louis University, Co-Investigator. $13,318. 

 

2. Fleur-de-lis: Role of FXR-FGF19 and TGR5-GLP2 axis in parenteral nutrition associated pediatric liver and gut injury. 07/01/2017 – 06/30/2018 

Role: Principal Investigator: Ajay Jain. $25,000 

 

3. NIH R13DK109671-01: Gastric Bypass: Role of the Gut. 2017: March 2018 

Title: A.S.P.E.N. 2017 Research Workshop. Role: Principal Investigator: Ajay Jain. $10,000 

 

4. NASPGHAN Young Investigator Award/Nestle Nutrition Award: (North American Society for Pediatric Gastroenterology, Hepatology and Nutrition): Nov 2014-Nov 2016 

‘Role of Bile Acids in Preventing Parenteral Nutrition Associated Disorders’ 

Site, Role: Principal Investigator: Ajay Jain. $150,000. 

 

5. A.S.P.E.N. Rhoads Research Foundation: (American Society for Parenteral and Enteral Nutrition): 01/01/2014-12/31/2015 

‘Novel Interventions Modulating the FXR-FGF19 Axis and the TGR5-GLP Axis as Therapeutic Approaches for TPN Associated Pathologies’ 

Site, Role: Principal Investigator: Ajay Jain. $50,000 

 

6. Thrasher Fund: Shear wave sonoelastography for the noninvasive evaluation of hepatic fibrosis in the pediatric population. May 2015 

Role: Collaborator. 

 

7. NIH/NIDDK, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases - Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC) Childhood Liver Disease Research and Education network (ChiLDREN). Jun 2011 

Role: Site Sub-Investigator. 

 

8. SLU Liver Center Grant: 03/01/2015-06/30/2017 

‘Role of Glucagon Like Peptides (GLPs) in Total Parenteral Nutrition’ 

Site, Role: Principal Investigator: Ajay Jain. $25,000. 

 

9. Fleur-de-lis:Role of enteral bile acids as gut growth promoters in an animal model of short bowel syndrome. 07/01/2016 – 06/30/2017 

Role: Co- Principal Investigator: Ajay Jain. $25,000 

 

10. Fleur-de-lis Grant Award: 07/1/2014-06/30/2015 

‘Role of Glucagon-Like Peptides and Oleanolic Acid in Total Parenteral Nutrition (TPN) associated gut and hepatic dysfunction’ 

Site, Role: Principal Investigator: Ajay Jain. $25,000 

 

11. Presidents Research Fund: 03/01/2014-02/28/2015 

‘New Strategies for Parenteral Nutrition Associated Liver and Gut Disease’ 

Site, Role: Principal Investigator: Ajay Jain. $47,000 

 

12. Departmental Funds from Chairman – Jain PI 07/01/12 – 03/30/2014 

‘A newer modality of total parenteral nutrition infusion in piglets’ 

Site, Role: Principal Investigator: Ajay Jain. $20,000 

 

13. American Liver Foundation Jain, PI 2008-2009 

‘Role of Farnesoid X Receptor (FXR) and Fibroblast Growth Factor 19 (FGF19) In Parenteral Nutrition Associated Liver Disease (PNALD)’ 

Site, Role: Principal Investigator: Ajay Jain. $12,500 

 

14. Indian Council of Medical Research Jain, PI 2001-2004 

‘Seroefficacy of Hepatitis B Vaccine Administered in The Expanded Programme of Immunization at 0, 6 wks and 9 months’ 

Site, Role: Maulana Azad Medical College, Delhi. Principal Investigator: Ajay Jain. $10,000 

 

Professional Services 

National Program Committee: 

American Society for Parenteral and Enteral Nutrition (ASPEN) Program Committee: (Jan 2018- 

Current); NIH Research Workshop 2020: Principal Investigator 

Pediatric Program Committee: American Society for Parenteral and Enteral Nutrition: (Jan 2018-Current) 

NIH Nonalcoholic steatohepatitis Pediatric Committee: (2011- Current) 

 

National Committee Member: 

Chair: Research Committee, American Society for Parenteral and Enteral Nutrition (2018-Current) 

Co-Chair: NASPGHAN Research Resources Sub-Committee (Oct 2015-Current) 

Co-Chair: American Liver Foundation, Mid America Advisory Board (Jul 2018-Current) 

NASPGHAN Research Committee: (Aug 2015-Current) 

US Expert Panel on Lysosomal Acid Lipase Deficiency: (Dec 2014-Current) 

American Society for Parenteral and Enteral Nutrition: (May 2014-Current) 

Studies of Pediatric Liver Transplantation (SPLIT): (Sep 2013-Current) 

 

Moderator (National Liver and GI Meeting): 

Moderator: A new era of research: NASPGHAN 2018 

Moderator: Nutrition and Metabolism Research Paper Session: Malnutrition, Obesity, Practice Concepts: Clinical Nutrition Week (CNW): Feb 2017 

Moderator: Studies of Pediatric Liver Transplantation (SPLIT): Liver Cancers: Sep 2016 

Moderator: ‘US Pediatric Hepatology Meeting: LAL-D: Saint Louis 2015 

Moderator: ‘Clinical patterns and Early Influences on NAFLD’: NASPGHAN 2015 

State of Art Research Session: ‘Pediatric Liver Research’: NASPGHAN 2014 

 

Board Member (Midwest region): 

ASPEN Rhoads Research Foundation, Board Member: (2018-Current) 

Liver Review Board Member: United Network For Organ Sharing (UNOS) / Organ Procurement 

And Transplantation Network /(OPTN): (Mar 2013 – Current) 

 

Professional Development Committee (National): 

North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (2007-2009) 

 

Resident Curriculum Committee: 

Department of Pediatrics, Medical College of Georgia (2005-2006) 

International: Indian Academy of Pediatrics: GI and Liver Reviewer 

 

Saint Louis University: 

Section Head: Pediatric Nutrition: Saint Louis University, St Louis . 2018-present 

Chairman: Nutritional Advisory Committee: Cardinal Glennon Children’s Medical Center (Jan 

2011- Current) 

Saint Louis University Compensation Committee, Feb 2018 – Current 

Saint Louis University Finance Committee, Feb 2018 - Current 

Member: Hospital Mission Committee 2015-2016 

Moderator (Platform Session): Pediatric Science Days Research Symposium, Apr 2014 

 

Grant Reviewer / Study Section: 

American Society for Parenteral and Enteral Nutrition Vars Award Reviewer, Jan 2017 

NASPGHAN Foundation Young Investigator Grants, Aug 2016 

Studies of Pediatric Liver Transplantation (SPLIT): Organizational Research Grants, Jan 2016 Studies of Pediatric Liver Transplantation (SPLIT): Organizational Research Grants, Jun 2015 

Grant Reviewer: President Research Fund, Saint Louis University, Jun 2015 

 

National/International Conference Organizer – NIH R13: 

American Society for Parenteral and Enteral Nutrition: Research Workshop. ‘Gastric Bypass: Role of the Gut’. Principal Investigator 

 

Bibliography 

RECENT PEER REVIEWED MANUSCRIPTS 

1. Denton C, Price A, Friend J, Manithody C, Blomenkamp K, Westrich M, Kakarla V, Philips W, Krebs J, Abraham S, Osei H, Jain AK. Role of the Gut-Liver Axis in Driving Parenteral Nutrition Associated Injury. Children (Accepted, In Print Sep 2018) 

 

2. Shapiro WL, Yu E, Collins J, Murray K, Ali S, Desai N, Xanthakos S, Lin H, Alkhouri N, Abdou R, Abrahams S, Butler M, Faasse SA, Gills L, Hadley TA, Jain AK, Kavan M, Kordy K, Lee P, Panganiban J, Pohl J, Potter C, Rudolph B, Sundaram S, Joshi S, Proudfoot J, Goyal N, Harlow K, Newton K, Schwimmer J. Clinical Practice Approach to Nonalcoholic Fatty Liver Disease by Pediatric Gastroenterologists in the United States, JPGN (Accepted, JPGN Sep 2018) 

 

3. Price A, Blomenkamp KS, Manithody C, Saxena S, Abraham S, Greenspon J, Villalona G, Jain AK. Developing a novel ambulatory total parenteral nutrition dependent short bowel syndrome animal model. Journal of Surgical Research. (Accepted, In Print, Aug 2018) 

 

4. Compher C, Jain AK, Nichol Peter, Blackmer A, Earthman C, Evans D, McCarthy M, Taylor B, Mehta N. Research Agenda 2018: the American Society for Parenteral and Enteral Nutrition. JPEN, J Parenter Enteral Nutr. 2018 Jul;42(5):838-844 

 

5. Villalona G, Price A, Blomenkamp KS, Manithody C, Ratchford T, Saxena S, Westrich M, Kakarla V, Pochampally S, Phillips W, Heafner N, Korremla N, Greenspon J, Guzman M, Jain AK. No gut no gain! Enteral bile acid treatment preserves gut growth but is not protective for parenteral nutrition associated liver injury in a novel extensive short bowel animal model. Premier Research Paper. JPEN J Parenter Enteral Nutr. 2018;Apr:1–14 

 

6. Karlow KE, Africa JA, Wells A, Hou J, Beth PH, Behling CA, Jain AK, Molleston JP, Newton KP, Rosenthal P, Vos MB, Xanthak SA, Lavine J, Schwimmer JB, for the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease. J Pediatr. 2018 Apr 13. j.jpeds.2018.02.038. 

 

7. Seth R, Akinboyo I, Chhabra A, Qaiyum Y, Shet A, Gupte N, Jain AK, Jain SK. Mobile-Phone Incentives for Childhood Immunizations in Rural India. Pediatrics. 2018 Apr;141(4). pii: e20173455. doi: 10.1542/peds.2017-3455. Epub 2018 Mar 14 

 

8. Jain AK, Le Roux C, Puri P, Tavakkoli A, Miller NG, Laferrere B, Kellermayer R, DiBase JK, Martindale, RG, Wolfe BM. Proceedings of the 2017 ASPEN Research Workshop— Gastric Bypass: Role of the Gut. JPEN J Parenter Enteral Nutr. 2018;Feb 42:279–295 

 

9. Part of NASH CRN: Newton KP, Feldman HS, Chambers CD, Wilson L, Behling C, Clark JM, Molleston JP, Chalasani N, Sanyal AJ, Fishbein MH, Lavine JE, Schwimmer JB; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children. J Pediatr. 2017 Aug;187:141-146.e1 

 

10. Jain AK, Sharma A, Arora S, Blomenkamp KS, Jun I, Luong R, Westrich, DJ, Mittal A, Buchanan PM, Guzman MA, Long JP, Neuschwander-Tetri BA, Teckman JH. Preserved gut microbial diversity accompanies upregulation of TGR5 and hepatobiliary transporters in bile acid treated animals on Parenteral Nutrition. JPEN J Parenter Enteral Nutr. 2017 Feb;41(2):198-207. Premier Research Paper 

 

11. Schwimmer JB, Lavine JE, Wilson LA, Neuschwander-Tetri BA, Xanthakos SA, Kohli R, Barlow SE, Vos MB, Karpen SJ, Molleston JP, Whitington PF, Rosenthal P, Jain AK, Murray KF, Brunt EM, Kleiner DE, Van Natta ML, Clark JM, Tonascia J, Doo E. In Children with Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but does not Reduce Disease Activity Scores. Gastroenterology. 2016 Dec;151(6):1141-1154 

 

12. Jain AK, McOmber M, Gilger M. Foreign bodies of the esophagus in children. UpToDate, Sep 2, 2016 

 

13. Jain AK, Teckman JH. Wilson Disease: Hepatic Manifestations. Clinical Decision Support, Feb 2016 

 

14. Wooton-Kee CR, Jain AK, Michael A, Grusak MA, Finegold MJ, Lutsenko S, Moore DD. Elevated copper impairs hepatic nuclear receptor function in Wilson's disease. J Clin Invest. 2015 Sep;125 (9):3449-60. 

 

15. Jain AK, Wen JX, Blomenkamp KS, Arora S, Blaufuss TA, Rodrigues J, Long JP, Neuschwander-Tetri BA, Teckman, JH. Oleanolic Acid improves gut atrophy induced by Total Parenteral Nutrition (TPN). JPEN J Parenter Enteral Nutr. 2015 Apr 28: 2015 Premier Research Paper 

 

16. Mavers M, Blaufuss T, Friedman H, Becker BA, Jain AK. Eosinophilic esophagitis in a pediatric patient with Herpes simplex virus esophagitis. A cause or a consequence?. OJCMR, Vol 1, Issue 6: Oct 2015 

 

17. Jain AK, Teckman JH. Controversies in the mechanism of Total Parenteral Nutrition induced pathology. Children, Jul 2015, 2, 358-370. 

 

18. Jain AK, Wen JX, Arora S, Blomenkamp KS, Rodrigues J, Blaufuss TA, Liou VD, Burrin DB, Long JP, Teckman JH. Validating hyperbilirubinemia and gut mucosal atrophy with a novel ultra-mobile ambulatory Total Parenteral Nutrition piglet model. Nutrition Research. 2015 Feb;35(2):169-74. 

 

19. Vuppalanchi R, Jain AK, Deppe R, Yates KP, Comerford M, Masuoka HC, Neuschwander-Tetri BA, et al. Relationship between Changes in Serum Levels of Keratin 18 and Changes in Liver Histology in Children and Adults With Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2014 Dec;12(12):2121-30. 

 

20. Jain AK, Teckman JH. Newly identified mechanisms of Total Parenteral Nutrition (TPN) related liver injury. Advances in Hepatology. Volume 2014, ID 621380, 7, 2014. 

 

21. Teckman JH, Jain AK. Advances in alpha-1-antitrypsin deficiency liver disease. Curr Gastroenterol Rep. 2014 Jan;16(1):367 

 

22. Part of NASH CRN: St-Jules DE, Watters CA, Brunt EM, et al. Estimation of fish and omega-3 fatty acid intake in pediatric nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2013 Nov;57(5):627-33 

 

23. Jain AK, Stoll B, Burrin DG, Holst JJ, Moore DD. Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs.Am J Physiol Gastrointest Liver Physiol. 2012 Jan 15;302(2):G218-24. 

 

24. Milligan KL, Jain AK, Garrett JS, Knutsen AP. Gastric ulcers due to varicella-zoster reactivation. Pediatrics. 2012 Nov;130(5) 

 

25. Jain AK, Teckman JH. Alpha-1-Antitrypsin Deficiency Liver Disease and New Treatment Opportunities. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2011 

 

26. Jain AK, Motil K, Abramson SL, Han YS, Tatevian N. Rectal ulcer with an elusive diagnosis: All that ulcers is not Crohns. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):367-9. 

 

27. Jain AK, Motil K, Olutoye O, Egler RA, Tatevian N. Signet Ring Cell Carcinoma without Microsatellite Instability-An Unusual Suspect. J Pediatr Gastroenterol Nutr. 2009 Jan;48(1):110-4. 

 

28. Kellermeyer R, Jain AK, Deguzman MM, Guillerman RP, Ferry G. Clinical challenges and images in GI. Aortitis as a rare complication of Crohn's disease. Gastroenterology 2008 Mar;134(3):668, 898. 

29. Jain AK, Mittal SK, Ramji S, Chakravarti A : Hepatitis B vaccine in the EPI schedule. Indian J Pediatrics. 2005 Aug; 72(8):661-4 

 

30. Jain AK, Dubey AP, Sudha S: Idiopathic hypereosinophilic syndrome - unusual presentation. Indian Pediatrics, 2004 Jan 7;41(1):79-82. 

 

31. Jain AK, Kumar A, Antiretroviral Therapy in Children, Pediatrics Today, 2000,3: pg 820-828 

 

32. Jain AK, BETARU: An indigenously designed cordless stethoscope, Indian Pediatrics, May 2000, Volume 37, pg 566-567. 

 

CONTRIBUTION TO SCIENCE: KEY MANUSCRIPT DESCRIPTION 

 

Gut-Liver Crosstalk: Our lab has reported on many aspects of the molecular mechanisms of hepatocellular and gut injury associated with TPN. Our key publication in the American Journal of Physiology for the first time explored the unique hypothesis that TPN associated injury is a result of a disruption of the Gut-systemic cross talk due to a lack of luminal nutrient induced signaling. This work raised the provocative prospect that bile acids, which were generally thought of as toxic agents may have therapeutic utility in the clinical context of TPN associated pathology as regulated by key hepatobiliary nuclear receptors and transporters. Using bile acids as a gut nuclear receptor - Farnesoid X Receptor agonist, significant improvement in hepatic dysfunction was established. Recently as part of K08 funding we evaluated gut FXR agonist in animals with bowel resection to further explore mechanistic links driving gut signaling. 

1. Jain AK, Stoll B, Burrin DG, Holst JJ, Moore DD. Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs. Am J Physiol Gastrointest Liver Physiol. 2012 Jan 15;302(2):G218-24. 

 

2. Villalona G, Price A, Blomenkamp KS, Manithody C, Ratchford, Thomas, Saxena, Saurabh, Westrich M, Kakarla V, Pochampally S, Phillips W, Heafner N, Korremla N, Greenspon J, Guzman M, Jain AK. No gut no gain! Enteral bile acid treatment preserves gut growth but is not protective for TPN associated liver injury in a novel extensive short bowel animal model. Premier Research Paper. JPEN J Parenter Enteral Nutr. 2018;Apr:1–14 

 

Novel Ambulatory TPN Model: The manuscript presented below detail our major advancement to the current model systems used for research in the field of TPN therapy. Because TPN involves intravenous infusion over long duration of time, the stability and feasibility of long-term maintenance of indwelling catheters in animal models is a big concern. Current technology has allowed human patients on TPN to use a portable, ambulatory, unobtrusive mobile pump as the method of delivery. However, prevailing TPN infusion animal models involve tethering of the animals to maintain catheters, which is stressful for animals and thus know to alter hepatobiliary receptors and transporters. Using ultra-small ambulatory pumps, tunneled catheters and customized animal jackets, our lab has established, for the first time a new untethered ambulatory animal model to study TPN therapy which recapitulates human injury and nutrition delivery. 

3. Jain AK, Wen JX, Arora S, Blomenkamp KS, Rodrigues J, Blaufuss TA, Liou VD, Burrin DB, Long JP, Teckman JH. Validating hyperbilirubinemia and gut mucosal atrophy with a novel ultramobile ambulatory Total Parenteral Nutrition piglet model. Nutrition Research. 2015 Feb;35(2):169-74. 

4. Jain AK, Teckman JH. Controversies in the mechanism of Total Parenteral Nutrition induced pathology. Children, Jul 2015, 2, 358-370. 

Regulations of Gut Growth with TPN: Our work further explored gut growth related to luminal signals during TPN therapy. Regulation of gut proliferative effects due to the bile acid activated gut G-coupled receptor (TGR5) and downstream Glucagon Like Peptides (GLPs) was pioneered in this study, published as a premier research paper in the ‘Journal of Parenteral and Enteral Nutrition’. For the first time the existence of divergent pathways regulating hepatocellular integrity via the nuclear receptor FXR-Fibroblast Growth Factor 19 pathway and gut mucosal proliferation via the TGR5-GLP axis in the context of TPN therapy were established. 

5. Jain AK, Wen JX, Blomenkamp KS, Arora S, Blaufuss TA, Rodrigues J, Long JP, Neuschwander-Tetri BA, Teckman, JH. Oleanolic Acid improves gut atrophy induced by Total Parenteral Nutrition (TPN). JPEN J Parenter Enteral Nutr. 2015 Apr 28: 2015 Premier Research Paper 

6. Jain AK, Teckman JH. Newly identified mechanisms of Total Parenteral Nutrition (TPN) related liver injury. Advances in Hepatology. Volume 2014, ID 621380, 7, 2014. 

Gut Microbiota: Our work was novel in describing the gut microbial changes during TPN therapy and its modulation by exogenous bile acid analogues. The existence of complimentary pathways regulating gut proliferation was speculated based on responses noted with the TGR5 signaling. Our study demonstrated a proliferation of phylum Bacteroidetes along with decreased Firmicutes and microbial diversity upon TPN infusion along with an alteration of key hepato-biliary receptors and transporters. It was thus recognized that such shifts in gut microbiota as noted with TPN may be additionally 

responsible for TPN-induced injury. This presented a paradigm change in our understanding of TPN associated injury. 

7. Jain AK, Sharma A, Arora S, Blomenkamp KS, Jun I, Luong R, Westrich, DJ, Mittal A, Buchanan PM, Guzman MA, Long JP, Neuschwander-Tetri BA, Teckman JH. Preserved gut microbial diversity accompanies upregulation of TGR5 and hepatobiliary transporters in bile acid treated animals on Parenteral Nutrition. JPEN J Parenter Enteral Nutr. 2016 Aug 8. Premier Research Paper 

 

ABSTRACTS/POSTERS/ORAL PRESENTATION 

 

1. Oral Platform Presentation: Guzman M, Price A, Manithody C, Blomenkamp K, Korremla N, Krebs J, Abraham S, Friend J, Osei H, Denton C, Villalona G, Greenspon J, Jain AK. Gut-systemic signaling drives total parenteral nutrition associated injury.(NASPGHAN 2018) 

 

2. Salomon JD, Price A, Manithody C, Jain AK. Effect of Cardiopulmonary Bypass on the Pediatric Intestinal Microbiome. Society of Critical Care Medicine. (Accepted Oct 2018) 

 

3. Poster of Distinction: Jain AK, Anand R, Lerrett S, Yanni GS, Mohammad S, Doyle M, Telega GW, Horslen SP. Outcomes Following Liver Transplantation in Young Infants. American Society for the Study of Liver Diseases (AASLD, 2018) 

 

4. Seth R, Akinboyo I, Chhabra A, Qaiyum Y, Shet A, Gupte N, Jain AK, Jain SK. Mobile-Phone Incentives for Childhood Immunizations in Rural India. NIH - 2018 mHealth Technology Showcase Committee. May 2018 

 

5. Premier Paper Session: Oral Presentation: Villalona G, Price A, Blomenkamp KS, Manithody C, Westrich M, Kakarla V, Pochampally S, Phillips W, Heafner N, Korremla N, Guzman M, Greenspon J, Jain AK. No gut no gain! Enteral bile acid treatment preserves gut growth but is not protective for TPN associated liver injury in a novel extensive short bowel animal model. (ASPEN Jan 2018) 

 

6. Puri P, Price A, Gillevet Patrick, Blomenkamp K, Sikaroodi M, Heafner N, Westrich M, Pochampally S, Kakarla V, Greenspon J, Villalona G, Guzman M, Long J, Tetri B, Teckman, JH, Jain AK. Firmicutes dominance is associated with lower serum bilirubin level in a novel ambulatory model of parenteral nutrition induced liver injury and gut atrophy. (NASPGHAN 2017) 

 

7. Shapiro WL, Africa J, Jain AK, Schwimmer J et al. Approach to the Management of Pediatric NAFLD by Pediatric Gastroenterologists and Hepatologists across the United States. (NASPGHAN 2017) 

 

8. Schwimmer JB, Wilson LA, Fishbein MH, Jain AK, Karpen SJ, Molleston JP, Murray KF, Newton KP, Rosenthal P, Vos MB, Xanthakos SA, Hoofnagle JH, Behling C, Clark JM, Lavine JE. Improvements in serum aminotransferase levels are associated with improvements in liver histology in children with nonalcoholic fatty liver disease (NAFLD). (AASLD 2017) 

 

9. Xanthakos SA, Lavine JE, Yates K, Schwimmer JB, Molleston JP, Rosenthal P, Murray KF, Vos MB, Jain AK, Fishbein M, Behling C, Brunt EM, Tonascia J and Doo E. Natural history of nonalcoholic fatty liver disease (NAFLD) in children receiving standard lifestyle counseling and placebo in NASH Clinical Research Network (CRN) trials. (AASLD 2017) 

 

10. Best Faculty Presentation Award: Oral Presentation: Jain AK, Sharma A, Blomenkamp KS, Garrett M, Jain A, Long JP, Neuschwander-Tetri BA, Teckman JH. Preserved gut microbial diversity accompanies upregulation of TGR5 in bile acid treated animals on Parenteral Nutrition. (Oral Presentation: Pediatric Science Days, May 2017) 

 

11. Farmakis SG, Guzman M, Buchanan P, Jain AK, Teckman JH. Shear wave sonoelastography correlates with liver biopsy fibrosis scores in pediatric patients with liver disease. The Society for Pediatric Radiology. (Vancouver, British Columbia, Canada, May 2017) 

 

12. Jain AK, Sharma A, Blomenkamp KS, Kornfeld D, Suresh A, Nitin T, Garrett M, Jain A, Long JP, Neuschwander-Tetri BA, Teckman JH. Enteral Bile Acid Treatment Preserves Gut Microbial Diversity and Regulates Hepatobiliary Transporters in Animals on Parenteral Nutrition. (SLU, AOA: Jan 2017) 

 

13. World Congress Plenary Presentation: Jain AK, Sharma A, Blomenkamp KS, Suresh A, Nitin T, Garrett M, Jain A, Long JP, Neuschwander-Tetri BA ,Teckman JH. Role of Bile Acids in Preventing Parenteral Nutrition associated disorders. (World Congress of Pediatric Gastroenterology Hepatology and Nutrition, Montreal, Oct 2016) 

 

14. Africa J, Jain AK, Schwimmer J et al Application of the NHLBI dyslipidemia guidelines in children with nonalcoholic fatty liver disease. World Congress Oct 2016 

 

15. Jain AK, Sharma A, Arora S, Blomenkamp KS, Luong R, Shainoju Korremla N, Suresh A, Westrich M, Kim E, Long JP, Teckman JH. Enteral Bile Acid Treatment Preserves Gut Microbial Diversity and Regulates Hepatobiliary Transporters In Animals on Parenteral Nutrition (Oral Presentation: Pediatric Science Days, Apr 2016) 

 

16. Premier Paper Session: Oral Presentation: Jain AK, Sharma A, Arora S, Blomenkamp KS, Jun I, Luong R, Westrich D, Mittal A, Long JP, Teckman JH. Preserved gut microbial diversity accompanies upregulation of TGR5 and hepatobiliary transporters in bile acid treated animals on Total Parenteral Nutrition (TPN) (ASPEN Jan 2016) 

 

17. Jain AK, Luong R, Tallam N, Blomenkamp KS, Arora S, Blaufuss T, Rodrigues J, Long JP, Tetri B, Teckman JH. Oleanolic Acid Improves Gut Atrophy Induced by Parenteral Nutrition. (AOA, Jan 2016) 

 

18. Schwimmer JB, Lavine JE, Tetri BN, Wilson L, Xanthakos SA, Barlow SE, Vos MB, Molleston JP, Whitington PF, Rosenthal P, Jain AK, Murray KF, Brunt EM, Kleiner DE, Van Natta ML, Clark JM, Tonascia J, Doo E. Cysteamine Bitartrate Delayed-Release (DR) for the Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in Children (CyNch) Trial. NIH Nonalcoholic Steatohepatitis Clinical Research Network. AASLD Nov 2015. 

 

19. Poster of Distinction: Sharma A, Ripa M, Blomenkamp KS, Jun IC, Teckman JH, Jain AK. Bile Acid Treatment of Total Parenteral Nutrition (TPN) infused animals induces divergence in gut microbial flora. (NASPGHAN, Oct 2015) 

 

20. Poster of Distinction: Wen JX, Arora S, Blomenkamp KS, Blaufuss TA, Teckman JH, Long JP, Jain AK. Glucagon-Like Peptides ameliorate Total Parenteral Nutrition associated gut atrophy. (Digestive Disease Week 2015) 

 

21. Premier Paper Session: Oral Presentation: Jain AK, Wen JX, Arora S, Blomenkamp KS, Blaufuss TA, Long JP, Teckman JH. Oleanolic Acid improves gut atrophy induced by Total Parenteral Nutrition (TPN) (ASPEN Feb 2015) 

 

22. Oral Platform Presentation: Jain AK, Wen JX, Arora S, Blomenkamp KS, Sharma A, Iqbal S, Rodrigues J, Liou V, Blaufuss TA, Long JP, Teckman JH. Total Parenteral Nutrition (TPN) causes gut mucosal atrophy and hyperbilirubinemia: We describe a novel ultra-mobile ambulatory model. (Oral Presentation, NASPGHAN 2014) 

 

23. AASLD Presidential Plenary Oral Platform Presentation: Jain AK, Deppe R, Yates KP, Comerford M, Masuoka HC, Molleston JP, Schwimmer JB, Lavine JE, Brunt EM, Tonascia J, Kleiner DE, Chalasani NP. Serum keratin fragment 18 (CK18) levels significantly predict changes in liver histology in children and adolescents with nonalcoholic fatty liver disease (NAFLD): Results from the TONIC trial. 

 

24. Jain AK, Blomenkamp KS, Rodrigues J, Blaufuss TA, Carl MA, Liou VD, Wen JX, Stoll B, Burrin DG, Long JP. Teckman, JH. Development and validation of a novel ultra-mobile ambulatory Total Parenteral Nutrition model. (Digestive Disease Week 2014) 

 

25. Rodrigues J, Braddock S, Jain AK. Eosinophilic Esophagitis in a child with Juvenile Polyposis associated with SMAD4 mutation. (NASPGHAN 2013) 

 

26. Rodrigues J, Sycamore K, Knutsen A, Jain AK. Lymphocytic esophagitis and celiac disease presenting after coin impaction: An incidental, exclusive or concomitant disease? (NASPGHAN 2013) 

 

27. Milligan KL, Jain AK, Foy T, Sigfried E, Knutsen A. Mesalamine treatment for colitis in ectodermal dysplasia with immunodeficiency. 2012 CIS Annual Meeting. May 2012, Chicago 

 

28. Waterhouse K, Katta A, Teckman J, Foy T, Derdoy J, Jain AK, Knutsen A, Becker B. Vitamin D Levels in Children with Eosinophilic Esophagitis and Gastroesophageal Reflux Disease. American Academy of Allergy Asthma and Immunology (2011 AAAAI) 

 

29. Mavers M, Shah A, Kumar S, Becker B, Jain AK. Eosinophilic esophagitis (EE) in a pediatric patient with Herpes simplex virus esophagitis (HSVE). A cause or a consequence? The dilemma continues. (2010 NASPGHAN) 

 

30. Jain AK, Barbara S, Burrin DG, Moore DD. "Enteral Bile Acids improve TPN related cholestasis and gut mucosal atrophy: Potential Role of FXR and FGF19" (2009 NASPGHAN) 

 

31. Jain AK, Barbara S, Burrin DG, Moore DD. Metabolic Alterations in Parenteral Nutrition Associated Liver Disease : Potential roles of Farnesoid X Receptor (FXR) and Fibroblast Growth Factor 19 (FGF19). (2008 NASPGHAN) 

 

32. Jain AK, Ma K, Moore DD. Replacement of zinc by copper in nuclear receptors may contribute to the pathogenesis of Wilson’s disease. (2008 Digestive Disease Week) 

 

33. Jain AK, Romero JJ, Lichtenberger LM. Phosphatidylcholine (PC)-conjugated 5ASA accelerates recovery from dextran sulfate sodium (DSS) colitis in rats. (2007 Crohns and Colitis Foundation) 

 

34. Jain AK, Eldin KW, Garner DK, Karpen S, Fishman DS. Non-Caseating granulomas in lymph nodes of a pediatric liver transplant recipient associated with parvovirus B19 infection. Texas Children's Hospital, Houston, Texas, USA. (2007 NASPGHAN) 

 

35. Jain AK, Motil K, Olutoye O, Tatevian N. Signet Ring Cell Carcinoma without Microsatellite Instability - An Unusual Suspect. (2007 NASPGHAN) 

 

36. Jain AK, Goei V, Arora P, Mittal SK. Newer Duodenal Biopsy Norms in Apparently Normal Children in Comparison to Those with Celiac Disease – Data from a Tertiary Care Center. Department of Pediatrics, Medical College of Georgia, Augusta, USA. (2005 NASPGHAN) 

37. Jain AK, Mittal SK, Ramji S, Chakravarti A. Incorporating Hepatitis B vaccine in the EPI, for Indian Infants : Seroefficacy of 0, 6 weeks and 9 months immunization schedule (along with DPT and measles vaccine). (2004 World Congress of Pediatric Gastroenterology, Hepatology and Nutrition. Paris, France)

Honors and Awards

Awards: 

  • NASPGHAN Nutrition Award: Oct 2018 
  • AASLD Presidential Poster of Distinction: Oct 2018 
  • National Award: Harry M Vars Award: Jan 2018 
  • National Institute of Health R13 Award: Feb 2017 
  • National Institute of Health K08 Award: Feb 2016 
  • National Institute of Health R03 (Co-I): 2015 
  • Fleur-De-Lis Award: Jul 2016 
  • ASPEN Rhoads Research Foundation Award: Jan 2015 
  • NASPGHAN Young Investigator Award/Nestle Nutrition Award: Nov 2014 
  • A.S.P.E.N. Rhoads Research Foundation Award: Jan 2014 
  • President’s Research Award: Jan 2014 
  • Fleur-De-Lis Award: Jul 2014 
  • American Liver Foundation: Alexander M. White, III Memorial Postdoctoral Research Fellowship Award. Jul 2008 
  • Oral presentation award: Texas Gulf Coast Gastroenterological Society Meeting: 2008 
  • Resident Research Award : Department of Pediatrics, Medical College of Georgia: 2004 
  • Senior Research Fellowship Award: Indian Council of Medical Research: 2001 (3 consecutive years) 

 

Honors: 

  • ASPEN Premier Paper Harry M Vars Session Presentation: Jan 2018 
  • World Congress of Pediatric Gastroenterology Hepatology and Nutrition: Plenary platform oral presentation. Montreal, Oct 2016. 
  • ASPEN Premier Paper Harry M Vars Session Presentation: Jan 2016 
  • ASPEN Premier Paper Harry M Vars Session Presentation: Feb 2015 
  • AASLD Presidential Plenary: Oct 2013 
  • Chairperson, International Conference: ‘IBD: Current Perspectives and Future Challenges’: April 2013 
  • National Institute of health (NIH): Pediatric Committee : July 2011
  • Flavors of Houston: Honored by the American Liver Foundation at the Houston event: 2008 
  • Certificate of appreciation: NASPGHAN: Professional Development Committee: 2006 
  • Delegate: Ped Gastro Con 2001, Sub specialty chapter of the Indian Academy of Pediatrics: 2001 
  • Delegate: CME in Gastroesophageal reflux in infancy and childhood. Department of pediatrics, division of gastroenterology, Maulana Azad Medical College: 2000 

Scholarship: Awarded at the National Level Science Talent Search Examination, India.