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You don't have permission to access /news/2022/september/The study, “Association of Male Hypogonadism with Risk of Hospitalization from COVID-19,” was published online Sept. 2 in JAMA Network Open. Sandeep Dhindsa, M.D., a professor of medicine and the director of SLU’s Division of Endocrinology, Diabetes and Metabolism, is first author on the paper. Abhinav Diwan, M.D., a cardiologist and professor of medicine at Washington University, is the study’s senior author. Cosette Champion, M.D., an internal medicine resident at Barnes-Jewish Hospital, an affiliate of Washington University, is second author on the paper. Dhindsa and Diwan have collaborated previously in 2021 on another study, “Relationship of circulating sex hormones with inflammation and disease severity in COVID-19,” published in JAMA Network Open. The cohort study looked at COVID-19 patients hospitalized at SSM Health and BJC Health Care between Jan. 1, 2017, and Dec. 31, 2021. Researchers collected data on demographics (age, BMI, race, ethnicity), medical conditions, hospitalization due to COVID-19, and the presence of testosterone therapy. In the study, 134 out of 723 men were hospitalized due to COVID-19. Men who required hospitalization were older, had more preexisting medical conditions and were more likely to be immunosuppressed than men who were not hospitalized. Men with low testosterone were twice more likely to require hospitalization from COVID, as compared to men with normal testosterone levels. Additionally, the hospitalization risk of men who were being treated with testosterone therapy was similar to men who had normal testosterone levels. “In 2020, at the outset of the pandemic, people thought testosterone was a risk factor for COVID,” Dhindsa said. “A few investigators surmised that drugs should be administered to lower testosterone levels to protect people from hospitalization due to COVID. However, this study shows the opposite. Low testosterone is linked to COVID-related hospitalizations.” Men with chronically low testosterone have weaker muscle mass and strength, which contribute to reduced lung capacity and ventilator dependence. Dhindsa says prospective clinical trials are needed to explore the efficacy of testosterone therapy in preventing hospitalizations after COVID and similar respiratory illnesses in men with hypogonadism. Saint Louis University School of Medicine Established in 1836, Saint Louis University School of Medicine has the distinction of awarding the first medical degree west of the Mississippi River. The school educates physicians and biomedical scientists, conducts medical research, and provides health care on a local, national and international level. Research at the school seeks new cures and treatments in five key areas: cancer, liver disease, heart/lung disease, aging and brain disease, and infectious diseases. on this server.