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10-010 - Virus-expressing host costimulation molecules


Lynda A. Morrison, Lydia G. Thebeau and Jane E. Schrimpf


A composition patent and method of manufacturing an antiviral vaccine that encodes costimulation molecules for increasing immune response to the particular virus at issue is provided herein. In an illustrative embodiment, replication-defective HSV encoding B7-1 or B7-2 molecules partially reconstituted immune responses to HSV compared to replication-defective virus alone when used to immunize B7KO mice.

Intellectual Property Status

  • U.S. patent 8,257,712