13-023 - Method for reducing incidence of fibrosis caused by peritoneal dialysis

Category: Therapeutic

Inventors: Alireza R. Rezaie, PhD, Peyman Dinervand, MD

Summary: Peritoneal dialysis is an alternative to hemodialysis as a treatment for end-stage renal disease and is based on the use of the peritoneum as a permeable membrane whereby ultrafiltration and diffusion between dialysate and blood can take place across the peritoneum. During continuous ambulatory peritoneal dialysis (CAPD) chronic injury occurs which leads to failure of filtration. This invention relates to the use of activated Protein C (APC) as a therapeutic drug for inhibiting dialysis-mediated peritoneal fibrosis.

Patent: U.S. patent application 14/47,684