Division of Allergy and Immunology

The pediatric and internal medicine allergy and immunology divisions provide an allergy and immunology fellowship training program.

The division also regularly provides electives for pediatric residents and medical students. Division members are active in the American Academy of Allergy, Asthma, and Immunology (AAAAI), the American College of Allergy, Asthma, and Immunology (ACAAI), and the World Allergy Organization (WAO) serving on committees, presenting talks and abstracts.

Learn More About the Fellowship

The division provides clinical care of allergic and immunologic diseases, including:

  • Asthma
  • Allergic conjunctivitis
  • Urticaria/angioedema
  • Eosinophilic esophagitis/gastroenteritis
  • Anaphylaxis
  • Allergic bronchopulmonary aspergillosis
  • Congenital immunodeficiency diseases
  • Acquired immunodeficiency diseases, e.g., AIDS
  • Allergic and nonallergic rhinitis
  • Atopic dermatitis (eczema)
  • Food allergy
  • Drug allergy
  • Latex allergy
  • Adverse reaction to vaccines
  • Insect allergy
  • Hypersensitivity pneumonitis
  • Sinusitis
  • Fungal sinusitis

Special Services

Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies

The immunodeficiency at SSM Health Cardinal Glennon Children's Hospital is a referral center for the Jeffrey Modell Foundation (JMF) and Immunodeficiency Foundation (IDF). The division works with the Bone Marrow Transplantation Division in transplantation of severe T-cells.

Allergy Challenge Clinic

The Allergy and Immunology Division has developed special clinics to perform food and drug challenges to evaluate for these allergic diseases.

Asthma Center for Children

SLU's Divisions of Allergy and Immunology and Pulmonology formed an Asthma Center to provide care for pediatric asthma patients.

Eosinophilic Esophagitis Clinic
The division formed this clinic led by Dr. Bradley Becker to provide care for pediatric patients with eosinophilic gastrointestinal diseases.
Clinical Immunology Laboratory

The Allergy and Immunology Division maintains a Clinical Immunology Laboratory as a reference laboratory to pathology that is CAP and CLIA certified. The laboratory performs diagnostic cellular functional studies, including lymphocytes proliferation, cellular cytotoxicity and cytokine synthesis. In addition, specialized studies to analyze T-cell signaling, CD40L expression and NBT are available.

Community Service

Allergy and Immunology Division members are active in the Asthma and Allergy Foundation of America, St. Louis Chapter. The division helps coordinate with the AAFA St. Louis Chapter an annual asthma screening for at-risk participants in the St. Louis Cardinals' Redbird Rookies Little League.

Research Highlights

Grants

  • Primary Immune Deficiency Treatment Consortium
    Rare Diseases Consortia for the Rare Diseases Clinical Research Network
    Source: NIH U54 AI082973
    Protocol 6901 - A prospective study of SCID infants who receive HCT
    Protocol 6902 - Retrospective & cross-sectional study of the results of HCT in SCID
    Protocol 6903 - Early and long-term outcomes following HCT of WAS
    Protocol 6904 - Early and long-term outcomes following HCT of CGD
  • Jeffrey Modell Diagnostic & Research Center for Primary Immunodeficiencies
    Source: Jeffrey Modell Foundation
    Center PI: Alan P. Knutsen MD
    A Two-Cohort, Open-Label, Prospective, Multicenter Study of the Safety, Tolerability, Efficacy and Pharmacokinetics of ProMetic BioTherapeutics Immune Globulin Intravenous (Human) 10% in Subjects with Primary Immunodeficiency Diseases
    Sponsor: ProMetic Biotherapeutics, Inc
    A Phase III, Multicenter, Open-Label Study to Evaluate the Pharmacokinetics and
  • Safety of Subgam VF in Primary Immunodeficiency Diseases (PID)
    Sponsor: Bio Products Laboratories
    An Open, Prospective, Multicentre Study Investigating Clinical Efficacy, Safety, and Pharmacokinetic Properties of the Human Normal Immunoglobulin for
  • Intravenous Administration BT595 as Replacement Therapy in Patients with Primary Immunodeficiency Disease (PID)
    Sponsor: Biotest
  • A Prospective, Open¬Label, Multicenter Study of the Efficacy, Safety, Tolerability, and Pharmacokinetics of Therapure PlasmaCap IG in Adults and Children with Primary Immune Deficiency Diseases
    Sponsor: Therapure Biopharma Inc
  • Clinical Study to evaluate the efficacy, pharmacokinetics and safety of immunoglobulin intravenous (human) 10% (Newgam) in patients with primary immunodeficiency diseases
    Sponsor: Octapharma
    Period: 1-1-2010. Completed
  • A Phase III, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Lebrikizumab in Adolescent Patients with Uncontrolled Asthma who are on Inhaled Corticosteroids and a Second Controller Medication
    Sponsor: Hoffmann LaRoche
    Completed

Publications

  • Caruthers C, Knutsen AP. Five 5-year-old boy with specific antibody deficiency associated with TNFRSF13B C104R heterozygous mutation. Pediatr Allergy Immunol Pulmol 28(2): 132-134, 2015.
  • Knutsen AP, Leiva L, Caruthers C, Rodrigues J, Sorensen RU. Streptococcus pneumoniae antibody titers in Patients with antibody immunodeficiency receiving intravenous immunoglobulin (IVIG) compared to subcutaneous immunoglobulin (SCIG). Clin Exp Immunol 182(1):51-56, 2015. PMID 26230522
  • Mavers M, Blaufuss T, Friedman H, Becker BA, Jain AK. Eosinophilic esophagitis in a pediatric patient with Herpes simplex virus esophagitis. A cause or a consequence?. OJCMR, 1(6) 2015. ISSN 2379-1039
  • Wilmott RW, Becker BA. Pulmonology. In: Pediatric Secrets, 6th Edition 2015, pp 619-649. ISBN: 978-0-323-31030-7
    Rodriguez J, Caruthers C, Dykewicz M, Slavin RG, Knutsen AP. Diagnosis and optimal management of fungal-associated asthma and rhinitis. Expert Review of Clin Immunol 12(5):531-550, 2016. PMID 26776889
  • Knutsen AP. Cartilage hair hypoplasia. eMedicine, June 2016
  • Knutsen AP. Transient hypogammaglobulinemia of infancy. eMedicine (original 3:1-7, 2002) August 2016

Abstracts

  • Bray-Aschenbrenner A, Rodrigues J, Anderson E, Bhatla D, Knutsen AP, King M. Disseminated Mycobacterium avium-Intracellulare infection in a healthy 6yo girl. APA Conference, Kansas City, MO, September 2015.
  • Becker BA, Caruthers C, Al-Jureidini SB, Garrett J S. Non-Invasive Management of Myocarditis Despite a Negative Gadolinium-Enhanced Cardiac MRI in a 15-year-old Boy with Minocycline Triggered Dress Syndrome. J Allergy Clin Immunol 2015; 135:AB123.
  • Azmeh R, Vitale J, Becker BA, Dogged Persistence of Childhood Eosinophilic Esophagitis. Ann Allergy Asthma Immunol 2015; 115:A88.
    Caruthers CN, Rodrigues JM, Shams A, Bhatla D, Knutsen AP. Outcomes for umbilical cord blood transplantation in severe combined immunodeficiency disorders: ten-year experience. J Allergy Clin Immunol 137:AB277, 2016.
  • Krieger J, Nelson R, Vandas E, Subramanian S, Pan H, Warrier M Statewide Legislation Positively Impacts Attendance for Students With Asthma. Accepted for American College of Allergy, Asthma & Immunology Annual Meeting 2016.

Invited Presentations

Bradley A. Becker, M.D.

  •  "Eosinophilic Esophagitis Support Group", SSM Health Cardinal Glennon Children's Hospital, October 2015.
  • "Chronic Mucocutaneous Candidiasis", Annual JMF Primary Immune Deficiency CME Course, Saint Louis University, July 2016.

Alan P. Knutsen, M.D.

  • "Common Variable Immunodeficiency" 6th Annual JMF Conference Primary Immunodeficiency, St. Louis, MO 7-16-2016
  •  Gammaglobulin Treatment in B Cell PIDD" 6th Annual JMF Conference Primary Immunodeficiency, St. Louis, MO 7-16-2016