The pediatric and internal medicine allergy and immunology divisions provide an allergy
and immunology fellowship training program.
The division also regularly provides electives for pediatric residents and medical
students. Division members are active in the American Academy of Allergy, Asthma,
and Immunology (AAAAI), the American College of Allergy, Asthma, and Immunology (ACAAI),
and the World Allergy Organization (WAO) serving on committees, presenting talks and
The immunodeficiency at SSM Health Cardinal Glennon Children's Hospital is a referral
center for the Jeffrey Modell Foundation (JMF) and Immunodeficiency Foundation (IDF).
The division works with the Bone Marrow Transplantation Division in transplantation
of severe T-cells.
The Allergy and Immunology Division maintains a Clinical Immunology Laboratory as
a reference laboratory to pathology that is CAP and CLIA certified. The laboratory
performs diagnostic cellular functional studies, including lymphocytes proliferation,
cellular cytotoxicity and cytokine synthesis. In addition, specialized studies to
analyze T-cell signaling, CD40L expression and NBT are available.
Allergy and Immunology Division members are active in the Asthma and Allergy Foundation
of America, St. Louis Chapter. The division helps coordinate with the AAFA St. Louis
Chapter an annual asthma screening for at-risk participants in the St. Louis Cardinals'
Redbird Rookies Little League.
Primary Immune Deficiency Treatment Consortium Rare Diseases Consortia for the Rare Diseases Clinical Research Network Source: NIH U54 AI082973 Protocol 6901 - A prospective study of SCID infants who receive HCT Protocol 6902 - Retrospective & cross-sectional study of the results of HCT in SCID Protocol 6903 - Early and long-term outcomes following HCT of WAS Protocol 6904 - Early and long-term outcomes following HCT of CGD
Jeffrey Modell Diagnostic & Research Center for Primary Immunodeficiencies Source: Jeffrey Modell Foundation Center PI: Alan P. Knutsen MD A Two-Cohort, Open-Label, Prospective, Multicenter Study of the Safety, Tolerability,
Efficacy and Pharmacokinetics of ProMetic BioTherapeutics Immune Globulin Intravenous
(Human) 10% in Subjects with Primary Immunodeficiency Diseases Sponsor: ProMetic Biotherapeutics, Inc A Phase III, Multicenter, Open-Label Study to Evaluate the Pharmacokinetics and
Safety of Subgam VF in Primary Immunodeficiency Diseases (PID) Sponsor: Bio Products Laboratories An Open, Prospective, Multicentre Study Investigating Clinical Efficacy, Safety, and
Pharmacokinetic Properties of the Human Normal Immunoglobulin for
Intravenous Administration BT595 as Replacement Therapy in Patients with Primary Immunodeficiency
Disease (PID) Sponsor: Biotest
A Prospective, Open¬Label, Multicenter Study of the Efficacy, Safety, Tolerability,
and Pharmacokinetics of Therapure PlasmaCap IG in Adults and Children with Primary
Immune Deficiency Diseases Sponsor: Therapure Biopharma Inc
Clinical Study to evaluate the efficacy, pharmacokinetics and safety of immunoglobulin
intravenous (human) 10% (Newgam) in patients with primary immunodeficiency diseases
Sponsor: Octapharma Period: 1-1-2010. Completed
A Phase III, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy,
Safety, and Tolerability of Lebrikizumab in Adolescent Patients with Uncontrolled
Asthma who are on Inhaled Corticosteroids and a Second Controller Medication Sponsor: Hoffmann LaRoche Completed
Caruthers C, Fernandes H, Shams A, Rodrigues J, Bhatla D, Knutsen AP. Outcomes for
umbilical cord blood transplantation in severe combined immunodeficiency disorders:
Ten-year experience. Pediatr Allergy Pulmol Immunol 30(3):171-180, 2017. September
Dhandha MM, Siegfried EC, Knutsen AP. Treatment of selective antibody deficiency with
IVIG resulting in decreased frequency of Streptococcal infection and improvement of
guttate-psoriasis. Dermatol Online J 23(9):1-6, 2017. August 2017
Borte M, Melamed I, Pulka G, Pyringer B, Knutsen AP, Ochs HD, Kobayashi RH, Kobayashi
AL, Gupta S, Strach M, Smith W, Pituch-Noworolski A, Moy J. Efficacy and safety of
human intravenous immunoglobulin 10% (Panzyga) in patients with primary immunodeficiency
diseases: a two-stage multicentre, prospective, open-label study. J Clin Immunol 37:603-612,
2017 PMID 28755067 August
Heimall J, Logan BR, Cowan MJ, Notarangelo L, Griffith LM, Puck JM, Kohn D, Pulsipher
MA, Parikh S, Martinez C, Kapoor N, O’Reilly R, Boyer M, Pai SY, Goldman F, Burroughs
L, Chandra S, Kletzel M, Thakar M, Connelly J, Cuvellier G, Davila B, S hereck E,
Knutsen A, Sullivan K, DeSantes K, Gillio A, Haddad E, Petrovic A, Quigg T, Smith
A, Stenger E, Yin Z, Shearer WT, Fleisher T, Buckley RH, Dvorak CC. Immune reconstitution
and survival of 100 SCID patients post hematopoietic cell transplant: A Primary Immune
Deficiency Treatment Consortium Natural History Study. Blood, PMID 29021228
Knutsen AP. Transient hypogammaglobulinemia of infancy. eMedicine (original 3:1-7,
2002) August 2016
Knutsen AP. Cartilage hair hypoplasia. eMedicine, June 2016
Wilmott RW, Becker BA. Pulmonology. In: Pediatric Secrets, 6th Edition 2015, pp 619-649.
ISBN: 978-0-323-31030-7 Rodriguez J, Caruthers C, Dykewicz M, Slavin RG, Knutsen AP. Diagnosis and optimal
management of fungal-associated asthma and rhinitis. Expert Review of Clin Immunol
12(5):531-550, 2016. PMID 26776889
Mavers M, Blaufuss T, Friedman H, Becker BA, Jain AK. Eosinophilic esophagitis in
a pediatric patient with Herpes simplex virus esophagitis. A cause or a consequence?.
OJCMR, 1(6) 2015. ISSN 2379-1039
Bray-Aschenbrenner A, Rodrigues J, Anderson E, Bhatla D, Knutsen AP, King M. Disseminated
Mycobacterium avium-Intracellulare infection in a healthy 6yo girl. APA Conference,
Kansas City, MO, September 2015.
Becker BA, Caruthers C, Al-Jureidini SB, Garrett J S. Non-Invasive Management of Myocarditis
Despite a Negative Gadolinium-Enhanced Cardiac MRI in a 15-year-old Boy with Minocycline
Triggered Dress Syndrome. J Allergy Clin Immunol 2015; 135:AB123.
Azmeh R, Vitale J, Becker BA, Dogged Persistence of Childhood Eosinophilic Esophagitis.
Ann Allergy Asthma Immunol 2015; 115:A88. Caruthers CN, Rodrigues JM, Shams A, Bhatla D, Knutsen AP. Outcomes for umbilical
cord blood transplantation in severe combined immunodeficiency disorders: ten-year
experience. J Allergy Clin Immunol 137:AB277, 2016.
Krieger J, Nelson R, Vandas E, Subramanian S, Pan H, Warrier M Statewide Legislation
Positively Impacts Attendance for Students With Asthma. Accepted for American College
of Allergy, Asthma & Immunology Annual Meeting 2016.
Bradley A. Becker, M.D.
"Eosinophilic Esophagitis Support Group", SSM Health Cardinal Glennon Children's
Hospital, October 2015.
"Chronic Mucocutaneous Candidiasis", Annual JMF Primary Immune Deficiency CME Course,
Saint Louis University, July 2016.
Alan P. Knutsen, M.D.
"Common Variable Immunodeficiency" 6th Annual JMF Conference Primary Immunodeficiency,
St. Louis, MO 7-16-2016
Gammaglobulin Treatment in B Cell PIDD" 6th Annual JMF Conference Primary Immunodeficiency,
St. Louis, MO 7-16-2016
Administrative and Academic Office Phone: 314-268-4014 Fax: 314-268-2712 email@example.com