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Current Vaccine Studies

Healthy volunteers of all ages, races, and genders are needed to continue vaccine development at the Saint Louis University Center for Vaccine Development.

Participation in a vaccine study is voluntary and confidential. All study vaccines and tests are free of charge and volunteers receive compensation for time and travel.

BCG Vaccine Trial (18-55)

Tuberculosis (TB) is an infection caused by bacteria (germs) called Mycobacterium tuberculosis.  TB is a serious, world-wide problem.  There are nearly 8 million new cases and 2 million deaths from TB world-wide every year.  There are medicines to treat TB after it starts, but they are expensive, take a long time to work, and can cause significant side effects during drug treatment.

This study involves a procedure called Leukapheresis to collect large amounts of white blood cells that will be removed from your blood to study the immune response.

Key Points

  • To participate you must be healthy and between 18-55 years old and have not been vaccinated for Tuberculosis.
  • Up to 15 participants will be enrolled in this nine-month long study.
  • You will be compensated:
    • $75 for each of the seven visits
    • $10 for each of the four phone calls
    • $200 for each Leukapheresis procedure

For more information about the study, please contact the Vaccine Center at 314-977-6333 or 1-866-410-6333 (toll-free) and refer to Study #320, IRB:27913. 

Nova Flu Study (65 and older)

Infection with a flu virus is a major public health threat, because it is able to spread rapidly through populations and affect large numbers of people.  It is responsible for about 36,000 deaths each year in the U.S.  Many deaths occur among older people.  Current flu vaccines protect older people against flu, but not as well as desired.  The new flu vaccine contains something called an “adjuvant”, which is something that is mixed with the normal flu vaccine before it is given to a patient.  This adjuvant helps the body to have a better immune response to the vaccine, so it is more likely to stop you getting flu. If you participate in this second part of the study, you will receive either the adjuvanted vaccine dose picked in Part 1 or unadjuvanted high dose flu vaccine.  The vaccine in this study has a new type of adjuvant; it is not yet approved for use by the Food and Drug Administration (FDA).  The FDA approval process for the new flu vaccine starts with this study.

 Key Points

  • To participate, you must be 65 years of age or older
  • You cannot get the flu from the vaccine
  • Participation is strictly voluntary
  • A complimentary seasonal flu vaccine will be offered to all volunteers

Payment and Time Commitment

You will be compensated $75 per visit and $10 per phone call for participating.

There are about eight visits and about two phone calls over approximately 12 months as part of this study.

To discuss volunteering, please contact a nurse at 1-866-410-6333 (toll free) or at and refer to study # 311B , IRB # 25821.