Ana M. Pizarro, Ph.D.

Department of Natural Sciences
Chemistry

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Education

Ph.D. in Chemistry, Universidad Autónoma de Madrid, Spain, 2004

Practice Areas

• Chemistry

Publications and Media Placements

Journal Articles

Osmium(II) Tethered Half-Sandwich Complexes: pH-dependent Aqueous Speciation and Transfer Hydrogenation in Cells. S Infante-Tadeo, V Rodríguez-Fanjul, A Habtemariam and AM Pizarro. Chem. Sci. 2021, 12, 9287–9297. https://doi.org/10.1039/D1SC01939B. This article is part of the themed collections: 2021 Chemical Science HOT Article Collection and 2021 ChemSci Pick of the Week Collection, and Front Cover of the journal.

Activation of the Ir−N(pyridine) Bond in Half-Sandwich Tethered Iridium(III) Complexes. AC Carrasco, V Rodríguez‐Fanjul, AM Pizarro. Inorg. Chem. 2020, 59, 16454-16466.

Structurally Strained Half-Sandwich Iridium(III) Complexes As Highly Potent Anticancer Agents. AC Carrasco, V Rodríguez‐Fanjul, A Habtemariam, AM Pizarro. J. Med. Chem. 2020, 63, 4005-4021.

Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X‐Ray Imaging. JJ Conesa, AC Carrasco, V Rodríguez‐Fanjul, Y Yang, JL Carrascosa, P Cloetens, E Pereiro, AM Pizarro. Angew. Chem. Int. Ed. 2020, 59, 1270-1278.

Reversible pH-Responsive Behavior of Ruthenium(II) Arene Complexes with Tethered Carboxylate. F Martínez-Peña, S Infante-Tadeo, A Habtemariam, AM Pizarro*.Inorg. Chem. 2018, 57, 5657-5668.

Gold(III) bis(thiosemicarbazonate) compounds in breast cancer cells: Cytotoxicity and thioredoxin reductase targeting. V Rodríguez-Fanjul, E López-Torres, MA Mendiola and AM Pizarro. Eur. J. Med. Chem. 2018, 148, 372-383.

Control of Reversible Activation Dynamics of [Ru(η⁶:κ¹-C₆H₅(C₆H₄)NH₂)(XY)]ⁿ⁺ and the Effect of Chelating-Ligand Variation. F Martínez-Peña and AM Pizarro*. Chem.--Eur. J. 2017, 23, 16231-16241. DOI: 10.1002/chem.201701681.

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells. JM Hearn, I Romero-Canelón, AF Munro , Y Fu, AM Pizarro, MJ Garnett, U McDermott, NO Carragher, and PJ Sadler. Proc. Natl. Acad. Sci. U. S. A. 2015, 112(29), E3800-5

Cellular Accumulation, Lipophilicity and Photocytotoxicity of Diazido Platinum(IV) Anticancer Complexes. AM Pizarro, RJ McQuitty, FS Mackay, Y Zhao, JA Woods, and PJ Sadler. ChemMedChem 2014, 9, 1169-1175.

The Potent Oxidant Anticancer Activity of Organoiridium Catalysts. Z Liu, I Romero-Canelón, B Qamar, JM Hearn, A Habtemariam, NPE Barry, AM Pizarro, GJ Clarkson and PJ Sadler.  Angew. Chem. Int. Ed. 2014, 53, 3941-3946.

Mirror-image Organometallic Osmium Arene Iminopyridine Halido Complexes Exhibit Similar Potent Anticancer Activity. Y Fu, R Soni, MJ Romero, AM Pizarro, L Salassa, GJ Clarkson, JM Hearn, A Habtemariam, M Wills and PJ Sadler. Chem.--Eur. J. 2013 19(45), 15199-209.

Diazido Mixed-Amine Platinum(IV) Anticancer Complexes Activatable by Visible-Light Form Novel DNA Adducts. Y Zhao, JA Woods, NJ Farrer, KS Robinson, J Pracharova, J Kasparkova, O Novakova, H Li, L Salassa, AM Pizarro, GJ Clarkson, L Song, V Brabec and PJ Sadler. Chem.--Eur. J. 2013 19(29), 9578-91.

The Contrasting Chemical Reactivity of Potent Isoelectronic Iminopyridine and Azopyridine Osmium(II) Arene Anticancer Complexes. Y Fu, MJ Romero, A Habtemariam, ME Snowden, L Song, GJ Clarkson, B Qamar, AM Pizarro, PR Unwin and PJ Sadler. Chem. Sci. 2012, 3(8), 2485-2494. Edge Article.

Organometallic Ruthenium and Iridium Transfer-Hydrogenation Catalysts Using Coenzyme NADH as a Cofactor. S Betanzos-Lara, Z Liu, A Habtemariam, AM Pizarro, B Qamar and PJ Sadler. Angew. Chem. Int. Ed. 2012, 51, 3897-3900.

Designing Organometallic Compounds for Catalysis and Therapy. AL Noffke, A Habtemariam, AM Pizarro and PJ Sadler. Chem. Commun., 2012, 48, 5219-5246. Feature Article.

Organometallic Iridium(III) Cyclopentadienyl Anticancer Complexes Containing C,N-Chelating Ligands. Z Liu, A Habtemariam, AM Pizarro, GJ Clarkson and PJ Sadler. Organometallics 2011, 30 (17), 4702-4710.

Insights into the Acid-Base Properties of PtIV-diazidodiam(m)inedihyroxido Complexes from Multinuclear NMR Spectroscopy. L Ronconi, AM Pizarro, RJ McQuitty and PJ Sadler. Chem.--Eur. J. 2011, 17(43), 12051-12058.

Contrasting Reactivity and Cancer Cell Cytotoxicity of Isoelectronic Organometallic Iridium(III) Complexes. Z Liu, L Salassa, A Habtemariam, AM Pizarro, GJ Clarkson and PJ Sadler. Inorg. Chem. 2011, 50(12), 5777-5783.

Organometallic Half-Sandwich Iridium Anticancer Complexes. Z Liu, A Habtemariam, AM Pizarro, SA Fletcher, A Kisova, O Vrana, L Salassa, PCA Bruijnincx, GJ Clarkson, V Brabec and PJ Sadler. J. Med. Chem. 2011, 54(8), 3011-3026.

Activation Mechanisms for Organometallic Anticancer Complexes. AM Pizarro, A Habtemariam and PJ Sadler.Top. Organomet. Chem. 2010, 32, 21-56.

Book Chapters

Metal Ion-Nucleic Acid Interactions in Disease and Medicine in Nucleic Acid-Metal Ion Interactions. Ana M. Pizarro and Peter J. Sadler. Editor: Nicholas V. Hud, Royal Society of Chemistry, Cambridge, UK (2009), 350-416.

Cancer Chemistry: Designing New Drugs for Cancer Treatment (Chapter 15) in The Molecular Biology of Cancer. A bridge from Bench to Bedside, 2^nd Edition. Ana M. Pizarro and Peter J. Sadler. Editors: Stella Pelengaris and Michael Khan, John Wiley & Sons, Inc (2013), pp. 436-460.

Biologically targeted agents from bench to bedside (Chapter 16) in The Molecular Biology of Cancer. A bridge from Bench to Bedside, 2^nd Edition. Michael Khan, Peter J. Sadler, Ana M. Pizarro, and Stella Pelengaris. Editors: Stella Pelengaris and Michael Khan, John Wiley & Sons, Inc (2013), pp. 461-508.

Metal-DNA Coordination Complexes in Bioinorganic Fundamentals and Applications: Metals in Natural Living Systems and Metals in Toxicology and Medicine (Vol 3), in Comprehensive Inorganic Chemistry, 2^nd Edition. Ana M. Pizarro, Nicolas P.E. Barry and Peter J. Sadler. Editors: Jan Reedijk and Kenneth Poeppelmeier, Oxford:Elsevier Ltd (2013) p. 751-784.

Patents

Novel iridium/rhodium anti-cancer compounds Full Text By Habtemariam, Abraha; Liu, Zhe; Soldevila, Joan Josep; Pizarro, Ana Maria; Sadler, Peter John. From PCT Int. Appl. (2011), WO 2011148124 A1 20111201. Patent No.: US 9.408,853 B2; Date of Patent: Aug. 9, 2016.

Professional Organizations and Associations

Member of the Royal Society of Chemistry (RSC, London, UK), since 2010.

Member of the Real Sociedad Española de Química (RSEQ, Spain), since 2011.

Member of the American Chemical Society (ACS, USA), since 2018.