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Alexei V. Demchenko, Ph.D.

Professor; Department Chair
Chemistry

Education

M.S. in Chemical Engineering, Mendeleev University of Chemical Technology of Russia, 1988
Ph.D. in Organic Chemistry, Zelinsky Institute of Organic Chemistry, Russia, 1993

Research Interests

Stereocontrol and mechanism of glycosylation; Expeditious strategies for the synthesis of glycans; Synthetic glycopharmaceuticals; Human milk oligosaccharides and other food additives; Automated synthesis

Visit the Glycoworld website to learn about the Demchenko group research.

Publications and Media Placements

  • Y. Singh, S. Escopy, M. D. Bandara, K. J. Stine, and A. V. Demchenko. Chemical synthesis of human milk oligosaccharides: para-lacto-N-hexaose and para-lacto-N-neohexaose. Chem. Eur. J., 2023, 29, e202302288; http://dx.doi.org/10.1002/chem.202302288
  • A. Dent, S. Escopy, and A. V. Demchenko. Cooperatively catalyzed activation of thioglycosides that bypasses intermediacy of glycosyl halides. Chem. Eur. J., 2023, 29, e202300873; https://dx.doi.org/10.1002/chem.202300873
  • Y. Singh, S. A. Geringer, and A. V. Demchenko. Synthesis and glycosidation of anomeric halides: evolution from early studies to modern methods of the 21st century. Chem. Rev., 2022, 122, 11701-11758; https://doi.org/10.1021/acs.chemrev.2c00029
  • S. Escopy, Y. Singh, K. J. Stine, and A. V. Demchenko. HPLC-based automated synthesis of glycans in solution. Chem. Eur. J., 2022, 28, e202201180; http://doi.org/10.1002/chem.202201180
  • O. Slater, K. B. Dhami, G. Shrestha, M. Kontoyianni, M. R. Nichols, and A. V. Demchenko. Development of a simple and effective Lipid-A antagonist based on computational prediction. ACS Infect. Dis., 2022, 8, 1171-1178; https://doi.org/10.1021/acsinfecdis.2c00125
  • S. Escopy and A. V. Demchenko. Transition-metal-promoted activation of thioglycosides and related compounds. Chem. Eur. J., 2022, 28, e202103747; http://doi.org/10.1002/chem.202103747
  • S. Escopy, Y. Singh, K. J. Stine, and A. V. Demchenko. A Streamlined regenerative glycosylation reaction: direct, acid-free activation of thioglycosides. Chem. Eur. J., 2021, 27, 354-361; https://doi.org/10.1002/chem.202003479
  • S. A. Geringer, Y. Singh, D. J. Hoard, and A. V. Demchenko. A highly efficient glycosidation of glycosyl chlorides using cooperative silver(I) oxide - triflic acid catalysis. Chem. Eur. J., 2020, 26, 8053-8063; https://doi.org/10.1002/chem.201905576
  • M. P. Mannino and A. V. Demchenko. Synthesis of β-glucosides with 3-O-picoloyl-protected glycosyl donors in the presence of excess triflic acid: defining the scope. Chem. Eur. J., 2020, 26, 2938-2946; https://doi.org/10.1002/chem.201905278
  • M. P. Mannino and A. V. Demchenko. Synthesis of β-glucosides with 3-O-picoloyl-protected glycosyl donors in the presence of excess triflic acid: a mechanistic study. Chem. Eur. J., 2020, 26, 2927-2937; https://doi.org/10.1002/chem.201905277
  • M. Panza, K. J. Stine, and A. V. Demchenko. HPLC-assisted automated oligosaccharide synthesis: the implementation of the two-way split valve as a mode of complete automation. Chem. Commun., 2020, 56, 1333-1336; https://doi.org/10.1039/C9CC08876H
  • Y. Singh and A. V. Demchenko. Defining the scope of the acid-catalyzed glycosidation of glycosyl bromides. Chem. Eur. J., 2020, 26, 1042-1051; https://doi.org/10.1002/chem.201904185

BOOKS EDITED

  • Handbook of Chemical Glycosylation, A. V. Demchenko Ed., Wiley-VCH, 2008
  • Frontiers in Modern Carbohydrate Chemistry, A. V. Demchenko Ed., ACS Symp. Ser., 960, 2007

Honors and Awards

  • The Melville L. Wolfrom Award, American Chemical Society, Division of Carbohydrate Chemistry and Chemical Glycobiology (2024)
  • Co-Investigators of the Year Award (with K. J. Stine), UM – St. Louis Office of Research (2020)
  • Outstanding Scientists Awards - Fellows Award, Academy of Science - St. Louis (2020)
  • Senior Investigator of the Year Award, UM – St. Louis Office of Research (2017)
  • American Chemical Society St. Louis Award (2014)
  • Chancellor’s Award for Excellence in Research and Creativity, UM – St. Louis (2013)
  • Mizutani Foundation for Glycoscience Award (2013)
  • New Investigator Award, American Chemical Society, Division of Carbohydrate Chemistry (2007)
  • CAREER Award, National Science Foundation (2005)

Professional Organizations and Associations

  • Fellow of the Saint Louis University Research Institute (from 2022)
  • Fellow of the Academy of Science – St. Louis (2020)
  • Chair, Division of Carbohydrate Chemistry, American Chemical Society (2020-2021)
  • The National Representative of the USA for the International Carbohydrate Organization (from 2019)
  • President of the U.S. Advisory Committee for the International Carbohydrate Symposia (from 2019)
  • Chair, Gordon Research Conference on Carbohydrates (2015)
  • Associate Editor, Journal of Carbohydrate Chemistry (2012-2021)