Division of Rheumatology

The Division of Rheumatology specializes in the care of both adults and children with rheumatic diseases with an emphasis on rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE) and other connective tissue diseases (CTD). The division is consistently ranked in the top 25 of rheumatology fellowship training programs.

Program Overview

The division is one of the most well known clinical rheumatology divisions in the Midwest, seeing more than 7,500 patients per year. We are also the eighth largest pediatric rheumatology clinic in the country. The division of rheumatology has both outstanding educational and research potential. The division holds an R01 research grant from the National Institutes of Health (NIH) for five years for studies in systemic lupus complexes and on immune regulatory T-cells headed by Anil Chauhan, M.D. We continue to have other basic projects in pediatric and adult rheumatology, as well as many transition projects in rheumatology being performed by our faculty.

We offer the largest rheumatology clinics in the Midwest for children and adolescents and the largest adult clinic in Missouri. The division also includes a rheumatology laboratory that offers a wide variety of immunological testing.

Faculty

The division consists of five full-time faculty members (M.D.s), one part-time faculty member (M.D.), four fellows in training, one Ph.D.  in the laboratory, and one laboratory associate (M.S.).

Publications
  • Moore TL: Juvenile idiopathic arthritis. In: "Conn's Current Therapy 2009", (eds) RE Rakel, ET Bope, pp 983-986, 2009
  • Low JM, Chauhan AK, Gibson DS, Zhu M, Chen S, Rooney ME, Ombrello MJ, Moore TL: Proteomic analysis of circulating immune complexes in juvenile idiopathic arthritis reveals disease associated proteins. Proteomics Clin App 3: 829-840, 2009
  • Reed MR, Gilliam BE, Syed RH, Moore TL: Rheumatic manifestation of Parvovirus B19 in children. J Pediatr Infect Dis 4: 321-331, 2009
  • Gilliam BE, Reed MR, Syed RH, Moore TL: Rheumatic manifestation of Epstein-Barr virus in children. J Pediatr Infect Dis 4: 333-342, 2009
  • Moore TL: Juvenile idiopathic arthritis. In "Conn's Current Therapy 2010," (eds) RE Rakel, ET Bope, Kellerman R, pp 987-989, 2010
  • Gilliam BE, Reed MR, Chauhan AK, Dehlendorf AB, Moore TL: Evidence of fibrinogen as a target of citrullination in IgM rheumatoid factor positive polyarticular juvenile idiopathic arthritis. Pediatr Rheumatol 9: 8: 1-16, 2011
  • Moore TL: Pathogenesis and diagnosis of viral arthritis: Update. Up to Date Rheumatol 19: 1-10, 2011-2014
  • Moore TL, Syed RH: Specific viruses that cause arthritis: Update. Up to Date Rheumatol 19: 1-18, 2011-2014
  • Chauhan AK, Moore TL: T-cell activation by the terminal complex of complement and immune complexes. J Biol Chem 287: 38627-38637, 2011
  • Gilliam BE, Reed MR, Chauhan AK, Dehlendorf AB, Moore TL: Significance of complement components Clq and C4 bound to circulating immune complexes in juvenile idiopathic arthritis: Support for classical complement pathway activation. Clin Exp Rheumatol 29: 1049-1056, 2011
  • Chauhan AK, Moore TL: Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human CD4+ T cells. Clin Exp Immunol 167: 235-245, 2012
  • Gilliam BE, Ombrello AK, Burlingame R, Pepmueller PH, Moore TL; Measurement of autoantibodies in pediatric and adolescent-onset systemic lupus erythematosus and their significant relationship with disease-associated manifestations. Semin Arthritis Rheum 41: 840-848, 2012
  • Moore TL: Diseases of the joints. In Pathy's "Principles and Practice of Geriatric Medicine", eds JE Morley, AJ Sinclair, B Velles (5th Edition), pp 1145-1152, 2012
  • Gilliam BE, Moore TL: The role of anti-cyclic citrullinated peptide (CCP) antibodies in early detection of rheumatoid arthritis: an overview of the INOVA Diagnostics, Inc. QUANTA lite CCP Assays. Expert Opin Med Diagn 10: 359-369, 2012 (PMed 23480744)
  • Gibson DS, Newell K, Evans AN, Finnegan S, Manning G, Scaife C, McAllister C, Pennington SR, Duncan MW, Moore TL, Rooney ME: Vitamin D binding protein isoforms as candidate predictors of disease extension in childhood arthritis. J Proteomics 10:1016-1029, 2012 (PMed 22771520)
  • Gilliam BE, Chauhan AK, Moore TL: Evaluation of anti-cyclic citrullinated type II collagen and anti-cyclic citrullinated vimentin autoantibodies in patients with juvenile idiopathic arthritis. Pediatr Rheumatol 11: 31:1-10, 2013 (PMed 23987731)
  • Syed R, Moore TL: Juvenile idiopathic arthritis: pathogenesis, presentation, and treatment, In "Encyclopedia of Medical Immunology", eds G Tsokos, IR Mackay, NR Rose, in press, 2013
  • Moore TL, Gilliam BE, Crespo-Pagnussats, Feller L, Chauhan AK: Measurement and evaluation of isotypes of anti-citrullinated fibrinogen and anti-citrullinated ?-enolase antibodies in juvenile idiopathic arthritis. Clin Exp Rheumatol 32: in press, 2014.
  • Chauhan AK, Chen C, Moore TL, DiPaolo RJ: Induced expression of Fc?RIIIa (CD16a) (CD/Ga) on CD4+ T cells triggers generation of IFN? high subset. J Biol Chem 290, in press, 2015.
  • Dalrymple AM, Moore TL: Laboratory evaluation in pediatric autoimmune disease. Ped Rev, in press, 2015.

Research Grants

Research Lab Priority Projects

  • Studies on systemic Lupus on Regulatory T-cells
  • Studies in Systemic Lupus on Interferon Signatures
  • Studies in Systemic Lupus on Syk and Immune Complexes
  • Studies in Juvenile Idiopathic Arthritis on Isotypes of Anti-CCP Antibodies and Rheumatoid
  • Factors and Glycosylation

Current Studies

R01 NIH Grant for Lupus Research 

Principal investigator: Anil Chauhan, Ph.D.
Co-principal investigator: Terry L. Moore, M.D.
$375,000/yr through 2017

Lupus and Juvenile Arthritis Research

Principal investigator: Terry L. Moore, M.D.
$25,000/yr (raised from Division's annual golf tournament

Juvenile Arthritis Research Award

Principal investigator: Terry L. Moore, M.D.
$25,000/yr

 

Corrona: Data Collection Program
 Principal Investigator: Peri Pepmueller, M.D.
CARRA (Childhood Arthritis and Research Alliance) Network “CARRANet”
 

Accelerating Toward an Evidence Based Culture in Pediatric Rheumatology: CARRA Registry

Principal Investigator: Reema Syed, M.D.

BENLYSTA™ Study

 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without BENLYSTA™ (Belimumab)

Principal Investigator: Reema Syed, MD