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Recent Faculty Publications

2023 Publications

Gomez K, Stratton HJ, Duran P, Loya S, Tang C, Calderon-Rivera A, François-Moutal L, Khanna M, Madura CL, Luo S, McKiver B, Choi E, Ran D, Boinon L, Perez-Miller S, Damaj MI, Moutal A*, Khanna R*. Identification and targeting of a unique NaV1.7 domain driving chronic pain. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2217800120. doi: 10.1073/pnas.2217800120. Epub 2023 Jul 27. PMID: 37498871; PMCID: PMC10410761. * co-last authors 

Daniela Salvemini and Ken Jacobson (NIDDK/NIH) published the editorial "Small molecules and biologics for future purinergic therapeutics" in Purinergic Signalling. 

Daniela Salvemini (Pharm/Phys) is a co-author on a review by Rocco Mollace et al "Modulation of the nitric oxide/cGMP pathway in cardiac contraction and relaxation: Potential role in heart failure treatment" in Pharmacological Research.

Ian de Vera, John Walker, Jinsong Zhang, Bahaa Elgendy (WUSTL/UHSP), and Lamees Hegazy (UHSP) are co-authors on IUPHAR review "International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily - Update 2023" in Pharmacological Reviews. 

J. Bruns, S. Nejat, A. Faber, *S. P. Zustiak, “Tumor Spheroid Fabrication and Encapsulation in Polyethylene Glycol Hydrogels for Studying Spheroid-Matrix Interactions”, 2023, Journal of Visualized Experiments, in press. INVITED for Special Issue on “Biomaterial-based Tumor Spheroid and Organoid Models for Drug Screening Applications” 

First author Joseph Krebs, with Sam Stealey, Alyssa Brown, Austin Krohn, Silviya Zustiak (BME) and Natasha Case (BME) published "Carrageenan-Based Crowding and Confinement Combination Approach to Increase Collagen Deposition for In Vitro Tissue Development" in Gels.

Wen Z, Pramanik A, Lewicki SA, Jung YH, Gao ZG, Randle JCR, Cronin C, Chen Z, Giancotti LA, Whitehead GS, Liang BT, Breton S, Salvemini, D, Cook DN, Jacobson KA. Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists. J Med Chem. 2023 Jun 29.

Morphine-induced osteolysis and hypersensitivity is mediated through toll-like receptor-4 in a murine model of metastatic breast cancer. Thompson AL, Grenald SA, Ciccone HA, Mohty D, Smith AF, Coleman DL, Bahramnejad E, De Leon E, Kasper-Conella L, Uhrlab JL, Margolis DS, Salvemini D, Largent-Milnes TM, Vanderah TW.Pain. 2023 Jun 15. doi: 10.1097

M. Flanagan, Q. Gan, #S. Sheth, R. Schafer, #S. Ruesing, L. E. Winter, K. Toth, *S. P. Zustiak, *A. M. Montaño, “Hydrogel delivery device for the in-vitro and in-vivo sustained release of active rhGALNS enzyme”, Pharmaceuticals, 2023, In press (IF: 5.215)

Geetika Aggarwal, John E. Morley, Bruno Vellas, Andrew D. Nguyen, Andrew A. Butler, the MAPT/DSA Group. Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults. GeroScience

West C*, Tobo C*, Au J, Johnson D, Mottaleb MA, Robinson J, Shringarpure S, Griggs DW, Garg K. Combined application of biosponges and an antifibrotic agent for the treatment of volumetric muscle loss. Am J Physiol Cell Physiol. 2023 Jun 1;324(6):C1341-C1352. PMID: 37184231. *co-first authors.

Ziemkiewicz N, Au J, Chauvin HM, Garg K. Electrically stimulated eccentric contraction training enhances muscle mass, function, and size following volumetric muscle loss. J Orthop Res. 2023 PMID: 37132367.

Wu XQ, Tan B, Du Y, Yang L, Hu TT, Ding YL, Qiu XY, Moutal A, Khanna R, Yu J, Chen Z. Glutamatergic and GABAergic neurons in the vLGN mediate the nociceptive effects of green and red light on neuropathic pain. Neurobiol Dis. 2023 Jul;183:106164. doi: 10.1016/j.nbd.2023.106164. Epub 2023 May 20. PMID: 37217103.

Stratton HJ, Boinon L, Gomez K, Martin L, Duran P, Ran D, Zhou Y, Luo S, Perez-Miller S, Patek M, Ibrahim MM, Patwardhan A, Moutal A, Khanna R. Targeting the vascular endothelial growth factor A/neuropilin 1 axis for relief of neuropathic pain. Pain. 2023 Jul 1;164(7):1473-1488. doi: 10.1097/j.pain.0000000000002850. Epub 2022 Dec 19. PMID: 36729125; PMCID: PMC10277229.

 Silviya Zustiak (BME) guest edited an issue of Frontiers in Biomaterials Science "Women in Biomaterials Science". Original research from the Zustiak lab, by first author Ether Dharmesh (BME) also appeared in the issue "Nanosilicate-hydrogel microspheres formed by aqueous two-phase separation for sustained release of small molecules".

Silviya Zustiak (BME) guest edited an issue in Pharmaceuticals "Feature Reviews in Pharmaceutical Technology". A review co-authored by Samuel Stealey (BME), Akhilesh K. Gaharwar (Texas A&M), and Silviya Zustiak also appeared in the issue "Laponite-Based Nanocomposite Hydrogels for Drug Delivery Applications".

Mukherjee S, Chakraborty M, Haubner J, Ernst G, DePasquale M, Carpenter D, Barrow JC and Chakraborty A*. The IP6K inhibitor LI-2242 ameliorates metabolic dysfunction in diet-induced obese mice. Biomolecules 2023, 13, 868; (*Corresponding author).

Sanchez-Navarro MJ, Borner T, Reiner BC, Crist RC, Samson WK, Yosten GLC, Stein L, Hayes MR. GPR-160 Receptor Signaling in the Dorsal Vagal Complex of Male Rats Modulates Meal Microstructure and CART-Mediated Hypophagia. Nutrients. 2023 May 11;15(10):2268. doi: 10.3390/nu15102268. PMID: 37242151; PMCID: PMC10221706.

Smith D.M., Niehoff M.L., Ling K., Jafar-Nejad P., Rigo F., Farr S.A., and Nguyen A.D. (2023) Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn-R493X mouse model of frontotemporal dementia. PLoS ONE 18(3):

Cao, F.; Kinthada, R.; Boehm, T.; D'Cunha, N. D.; Leus, I. V.; Orth, C.; Zgurskaya, H. I.; Walker, J. K. Identification and structure-activity relationships for a series of N,N,-disubstituted 2-aminobenzothiazoles as potent inhibitors of S. aureus. Bioorg. & Med. Chem. Lett., 2023, In press ahead of print.

Billon C., Sitaula S., Banerjee S., Welch R., Elgendy B., Hegazy L., Oh T. G., Kazantzis M., Chatterjee A., Chrivia J., Hayes M.E., Xu W., Hamilton A., Huss J. M., Zhang L., Walker J. K., Downes M., Evans R. M., Burris T.P. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023;18(4):756-771.

Michael Ariel, Shivika Ahuja, Daniel E. Warren; Responses of the in vitro turtle brain to visual and auditory stimuli during severe hypoxia. J Exp Biol 2023; jeb.244687

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Daniela Salvemini and Timothy M. Doyle have a paper published in JEM Targeting neuroinflammation in neuropathic pain and opioid use Daniela Salvemini1,2 and Timothy M. Doyle1,2

2022 Publications

Daniela Salvemini (Pharm/Phys), first author Kathryn Braden (Pharm/Phys), with co-authors including Chris Arnatt (Chemistry), and Jinsong Zhang (Pharm/Phys) published "Activation of GPR183 by 7α,25-dihydroxycholesterol induces behavioral hypersensitivity through MAPK and NF-κB" in the Journal of Pharmacology and Experimental Therapeutics.

Moniiruzzaman, M.; Cooper, C. J.; Uddin, M. R.; Walker, J. K.; Parks, J. M.; Zgurskaya, H. I.; Analysis of Orthogonal Efflux and Permeation Properties of Compounds Leads to the Discovery of New Efflux Pump Inhibitors. ACS Infect Dis, 2022, Ahead of Print PMID: 36070489

Walker, J. K.; Cao, F.; Boehm, T.; Ramakumar, K.; Amino benzothiazole compounds for treatment of antibiotic resistant bacteria. U.S. Patent, WO 20222067312, August 25th, 2022

Walker, J. K; Burris, T. P.; Situala, S.; Chatterjee, A.; D'Cunha, N. C.; Jacobsen, E. J.; Blinn, R. J.; Preparation of substituted purines and naphthyridines as REV-ERB agonists. WO 2022093552, May 5th, 2022

Sur S, Steele R, Ko BCB, Zhang J, Ray RB. Long non-coding RNA ELDR promotes cell cycle progression in normal oral keratinocytes through induction of a CTCF-FOXM1-AURKA signaling axis. J Biol Chem. 2022 Apr 1:101895. Epub ahead of print. PMID: 35378133.

Moe Watanabe, Caroline M. Kopruszinski, Aubin Moutal, Daigo Ikegami, Rajesh Khanna, Yanxia Chen, Sarah Ross, Kimberly Mackenzie, Jennifer Stratton, David W. Dodick, Edita Navratilova, Frank Porreca, Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine, Brain, 2022;, awac104,

Hisakatsu Ito, Edita Navratilova, Barbora Vagnerova, Moe Watanabe, Carol Kopruszinski, Luiz H. Moreira de Souza, Xu Yue, Daigo Ikegami, Aubin Moutal, Amol Patwardhan, Rajesh Khanna, Mitsuaki Yamazaki, Miguel Guerrero, Hugh Rosen, Ed Roberts, Volker Neugebauer, David W. Dodick, Frank Porreca, Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signalling to promote wakefulness and vigilance, Brain, 2022.

Mollasalehi N, Francois-Moutal L, Porciani D, Burke DH, Khanna M. Aptamers Targeting Hallmark Proteins of Neurodegeneration. Nucleic Acid Ther. 2022 Apr 22. Epub ahead of print. PMID: 35452303.

Ghoshal S, Mukherjee S, Chakraborty M, Msengi EN, Haubner J, Chakraborty A. Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction. Int J Mol Sci. 2022;23(4):2059. Published 2022 Feb 12.

Wen Z, Salmaso V, Jung YH, Phung NB, Gopinatth V, Shah Q, Patterson AT, Randle JCR, Chen Z, Salvemini D, Lieberman DI, Whitehead GS, Karcz TP, Cook DN, Jacobson KA. Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y14R Antagonist. J Med Chem. 2022;65(4):3434-3459. Published 2022 Feb 24.

Singh AK, Mahalingam R, Squillace S, Jacobson KA, Tosh DK, Dharmaraj S, Farr SA, Kavelaars A, Salvemini D, Heijnen CJ: Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice. Acta Neuropathologica Communications 2022, 10:11.

Stealey, S.; Khachani, M.; Zustiak, S.P. Adsorption and Sustained Delivery of Small Molecules from Nanosilicate Hydrogel Composites. Pharmaceuticals 2022, 15, 56.

​​Rossiter, J.L., Redlinger, L.J., Kolar, G.R., Samson, W.K., Yosten, G.L.C. The actions of C-peptide in HEK293 cells are dependent upon insulin and extracellular glucose concentrations. Peptides 150: 270728, 2022.

Samson, W.K., Yosten, G.L.C., Remme, C.A. A primer on obesity-related cardiomyopathy. Physiological Reviews 102(1): 1-6, 2022.

Samson, W.K., Yosten, G.L.C. A comprehensive review of the neuroscience of ingestion. Physiological Reviews 102(1): 319-322, 2022

Li J, Guo C, Rood C, and Zhang J. A C-terminus-dependent conformational change is required for HDAC3 activation by nuclear receptor corepressors. Journal of Biological Chemistry. J Biol Chem. 297(4):101192.

Steinauer N, Zhang K, Guo C, Zhang J. Computational modeling of gene-specific transcriptional repression, activation and chromatin interactions in leukemogenesis by LASSO-regularized logistic regression. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 18(6):2109-2122, 2022.

Braden, K., Stratton H.J., Salvemini, D. and Khanna, R. Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain. Neurobiol Pain 11:100082, 2022.

Squillace, S., and Salvemini, D. Nitroxidative stress in pain and opioid-induced adverse effects: therapeutic opportunities. Pain 163:205-213, 2022.

Leduc-Pessah, H., Xu, C, Fan, C.Y., Dalgarno, R., Kohro, Y., Sparanese, S., Burke, N.N., Jacobson, K.A., Altier C., Salvemini, D., Trang T. Spinal A(3) adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats. J Neurosci Res 2022, 100:251-64.

2021 Publications

Mukherjee S, Chakraborty M, Ulmasov B, McCommis K, Zhang J, Carpenter D, Msengi EN, Haubner J, Guo C, Pike DP, Ghoshal S, Ford DA, Neuschwander-Tetri BA, Chakraborty A. Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis. Mol Metab. 2021 Dec;54:101364.

Samson, W.K., Salvemini, D., Yosten, G.L.C. Overcoming stress, hunger and pain: cocaine- and amphetamine-regulated transcript peptide’s promise. Endocrinology 162(8): 1-6 2021.

Willis K Samson, Daniela Salvemini, Gina L C Yosten
, Overcoming Stress, Hunger, and Pain: Cocaine- and Amphetamine-Regulated Transcript Peptide’s Promise, Endocrinology, Volume 162, Issue 8, August 2021, bqab108,

Lauro,F., Giancotti, L.A., Kolar, G., Harada, C.M., Harmon, T.A., Garrett, T.J., and Salvemini, D. Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities. Cell Mol Neurobiol, 2021.

Martina Rosato, Brittany Hoelscher, Zhenguo Lin, Chidera Agwu, Fenglian Xu (2021) Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages. BMC Genomics 22 (1): 637. 637.

Banerjee, S., Ghoshal, S., Girardet, C., DeMars K.,Yang C., Niehoff, M., Nguyen A., Jayanth, P., Hoelscher, A., Xu, F., Banks, W., Hansen, K., Zhang, J., Candelario-Jalil E., Farr, S., Butler, A., Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice. npj Aging Mech Dis 7, 23 (2021).

Liang*, X., Janks*, L. & Egan, T.M. (2021, in press) Using Voltage Clamp Electrophysiology and Patch Clamp Photometry to Characterize P2X7 receptor currents. Methods in Molecular Biology. (*joint first authors).

Tewari, M., Khan, M., Verma, M., Mercier, P., Coppens, J., Kemp, J.M., Bucholz, R. & Egan, T.M. (2021) Physiology of cultured human microglia maintained in a defined culture medium. ImmunoHorizons 5:257-272. PMID: 33931497

Leduc-Pessah, H., C. Xu, C.Y. Fan, R. Dalgarno, Y. Kohro, S. Sparanese, N.N. Burke, K.A. Jacobson, C. Altier, D. Salvemini, and T. Trang. "Spinal A3 adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats.", June 2021, Journal of Neuroscience Research.

Tsegay KB, Adeyemi CM, Gniffke EP, Sather DN, Walker JK, Smith SEP. "A repurposed drug screen identifies compounds that inhibit the binding of the COVID-19 spike protein to ACE2." bioRxiv [Preprint]. 2021 Apr 8:2021.04.08.439071.

Kyle S. McCommis, Andrew A Butler, The Importance of Keeping Time in the Liver, Endocrinology 2021 Feb 1;162(2):bqaa230. doi: 10.1210/endocr/bqaa230, PMID: 33320193

Haddock CJ, Almeida-Pereira G, Stein LM, Hayes MR, Kolar GR, Samson WK, Yosten GLC. Signaling in rat brain stem via Gpr160 is required for the anorexigenic and antidipsogenic actions of cocaine- and amphetamine-regulated transcript. American Journal of Physiology Regulatory Integrative Comparative Physiology. 2021 Mar 1;320(3):R236-R249. doi: 10.1152/ajpregu.00096.2020. Epub 2020 Nov 18. PMID: 33206556

Andrade-Franzé GMF, Pereira ED Jr, Yosten GLC, Samson WK, Menani JV, De Luca LA Jr, Andrade CAF. Blockade of ERK1/2 activation with U0126 or PEP7 reduces sodium appetite and angiotensin II-induced pressor responses in spontaneously hypertensive rats. Peptides 2021 Feb;136:170439. doi: 10.1016/j.peptides.2020.170439. Epub 2020 Nov 7. PMID: 33166587

Matalon S, Remme CA, Samson WK. Physiological reviews: the past, the present and the future. Physiological Reviews 2021 Apr 1;101(2):733-738. doi: 10.1152/physrev.00001.2021. Epub 2021 Jan 14.PMID: 33444114

Yosten GLC, Haddock CJ, Harada CM, Almeida-Pereira G, Kolar GR, Stein LM, Hayes MR, Salvemini D, Samson WK. Past, present and future of cocaine- and amphetamine-regulated transcript peptide. Physiology and Behavior. 2021 Jun 1;235:113380. doi: 10.1016/j.physbeh.2021.113380. Epub 2021 Mar 8.PMID: 33705816

Durante, M., S. Squillace, F. Lauro, L. A. Giancotti, E. Coppi, F. Cherchi, L. Di Cesare Mannelli, C. Ghelardini, G. Kolar, C. Wahlman, A. Opejin, C. Xiao, M. L. Reitman, D. K. Tosh, D. Hawiger, K. A. Jacobson and D. Salvemini (2021). "Adenosine A3 agonists reverse neuropathic pain via T cell-mediated production of IL-10." Journal of Clinical Investigation 131(7) PMID 33621215, PMC8011899.

Jung, Y. H., V. Salmaso, Z. Wen, J. M. Bennett, N. B. Phung, D. I. Lieberman, V. Gopinatth, J. C. R. Randle, Z. Chen, D. Salvemini, T. P. Karcz, D. N. Cook and K. A. Jacobson (2021). "Structure-Activity Relationship of Heterocyclic P2Y14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres." Journal of Medicinal Chemistry 64(8): 5099-5122 PMID 33787273,

Luongo, L., F. Guida, S. Maione, K. A. Jacobson and D. Salvemini (2021). "Adenosine Metabotropic Receptors in Chronic Pain Management." Frontiers in Pharmacology 12: 651038 PMID 33935761, PMC8085424.

Renthal, W., A. Chamessian, M. Curatolo, S. Davidson, M. Burton, S. Dib-Hajj, P. M. Dougherty, A. D. Ebert, R. W. t. Gereau, A. Ghetti, M. S. Gold, G. Hoben, D. M. Menichella, P. Mercier, W. Z. Ray, D. Salvemini, R. P. Seal, S. Waxman, C. J. Woolf, C. L. Stucky and T. J. Price (2021). "Human cells and networks of pain: Transforming pain target identification and therapeutic development." Neuron 109(9): 1426-1429 PMID 33957072,

Steinauer N, Zhang K, Guo C, Zhang J. Computational modeling of gene-specific transcriptional repression, activation and chromatin interactions in leukemogenesis by LASSO-regularized logistic regression. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2021 May 7;PP. doi: 10.1109/TCBB.2021.3078128. Epub ahead of print. PMID: 33961561.

L. Hill, Bruns, S. P. Zustiak, Hydrogel matrix presence and composition influences drug responses of encapsulated glioblastoma spheroids, in press, 2021, Acta Biomaterialia ;

Bruno, J., and Edwards, J.C. Kidney-disease-associated variants of Apolipoprotein L1 show gain of function in cation channel activity. Journal of Biological Chemistry (2021) 296: 100238 PMID: 33380423

Liang, X., Janks, L. & Egan, T.M. (2021, in press) Using Voltage Clamp Electrophysiology and Patch Clamp Photometry to Characterize P2X7 receptor currents. Methods in Molecular Biology.

Tewari, M., Khan, M., Verma, M., Mercier, P., Coppens, J., Kemp, J.M., Bucholz, R. & Egan, T.M. (2021) Physiology of cultured human microglia maintained in a defined culture medium. ImmunoHorizons 5:257- 272. PMID: 33931497

Newton KP, Lavine J, Wilson L, Behling CA, Vos MB, Molleston JP, Rosenthal P, Miloh T, Fishbein MH, Jain AK, Murray KF, Schwimmer JB. Alanine Aminotransferase and Gamma Glutamyl Transpeptidase Predict Histologic Improvement in Pediatric Nonalcoholic Steatohepatitis. Hepatology. 73: 937-951, 2021. PMID: 32416645

Sengupta M, Abuirqeba S, Kameric A, Cecile-Valfort A, Chatterjee A, Griffett K, Burris TP, Flaveny CA. A two hit model of alcoholic liver disease that exhibits rapid, severe fibrosis. PLoS One. 2021 Mar 26;16(3):e0249316.. PMID: 33770118

Musicant AM, Parag-Sharma K, Gong W, Sengupta M, Chatterjee A, Henry EC, Tsai YH, Hayward MC, Sheth S, Betancourt R, Hackman TG, Padilla RJ, Parker JS, Giudice J, Flaveny CA, Hayes DN, Amelio AL.CRTC1/MAML2 directs a PGC-1 alpha IGF-1 circuit that confers vulnerability to PPARgamma inhibition. Cell Reports 2021 Feb 23;34(8):108768. PMID: 33626346

Mehla J.; Malloci G.; Mansbach R.; López C. A.; Tsivkovski R.; Haynes K.; Leus I. V.; Grindstaff S. B.; Cascella R. H.; D'Cunha N.; Herndon L.; Hengartner N. W.; Margiotta E.; Atzori A.; Vargiu A. V.; Manrique P. D.; Walker J. K.; Lomovskaya O.; Ruggerone P.; Gnanakaran S.; Rybenkov V. V.; Zgurskaya H. I. Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa. mBio. 2021 Jan 19;12(1):e02785-20. PMID 33468691

Zgurskaya H.I.; Walker J. K.; Parks J. M.; Rybenkov V. V. Multidrug Efflux Pumps and the Two-Faced Janus of Substrates and Inhibitors. Acc. Chem. Res. 2021 Feb 16;54(4):930-939. PMID 33539084

Tsegay K. B.; Adeyemi C. M.; Gniffke E. P.; Sather D. N.; Walker J. K.; Smith S. A repurposed drug screen identifies compounds that inhibit the binding of the COVID-19 spike protein to ACE2. bioRxiv. 2021 Apr 8:2021.04.08. PMID 33851160

Hirai, T., Y. Yang, Y. Zenke, H. Li, J.S. De La Cruz Diaz, P.Y. Zhou, B.A. Nguyen, L. Bartholin, D.W. Griggs, D. Masopust, and D.H. Kaplan. Competition for active TGF allows for selective retention of antigen-specific Trm in the epidermal niche. 2021. Immunity 54:1-15. PMID: 33212014

Hasan, M.M., E.E. Stebbins, R. K.M. Choy, J. R. Gillespie, E. L. de Hostos, P. Miller, A. Mushtaq, R. M. Ranade, J. E. Teixeira, C. L. M. J. Verlinde, A. Sateriale, Z. Zhang, D. M. Osbourn, D. W. Griggs, E. Fan, F. S. Buckner, C. D. Huston. Spontaneous selection of Cryptosporidium drug resistance in a calf model of infection. 2021. Antimicrob Agents Chemother (AAC). AAC.00023-21. doi: 10.1128/AAC.00023-21. PMID: 33753338

Noskovicova, N., R. Schuster, S. van Putten, M. Ezzo, A. Koehler, S. Boo, N. Coelho, D.W. Griggs, P. Ruminski, C. McCulloch, B. Hinz. Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β. 2021. Nature Biomedical Engineering. Doi: 10.1038/s41551-021-00722-z

2020 Publications

Brittany A Mersman, Wali Zaidi, Naweed I Syed, and Fenglia Xu Taurine Promotes Neurite Outgrowth and Synapse Development of Both Vertebrate and Invertebrate Central Neurons. Frontiers in Synaptic Neuroscience, 2020 July 22; 12:29. PMID: 32792935, PMCID: PMC7387692,

Selvamani Vijayalingam, Uthayashanker R Ezekiel, Fenglian Xu, T Subramanian, Elizabeth Geerling, Brittany Hoelscher, KayKay San, Aravinda Ganapathy, Kyle Pemberton, Eric Tycksen, Amelia K Pinto, James D Brien, David B Beck, Wendy K Chung, Christina A Gurnett, Chinna G Chinnadurai Human iPSC-Derived Neuronal Cells From CTBP1-Mutated Patients Reveal Altered Expression of Neurodevelopmental Gene Networks. Frontiers in Neuroscience, 2020 Oct 27; 14: 562292.
PMID: 33192249,

Subhashis Banerjee, Sarbani Ghoshal, Joseph R Stevens, Kyle S McCommis, Su Gao, Mauricio Castro-Sepulveda, Maria L Mizgier, Clemence Girardet, K Ganesh Kumar, Jose E Galgani, Michael L Niehoff, Susan A Farr, Jinsong Zhang, Andrew A Butler. Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction
Journal of Biological Chemistry 2020 Oct 2;295(40):13753-13768. doi: 10.1074/jbc.RA120.014381
PMID: 32727846

Andrew A Butler, James L Graham, Kimber L Stanhope, So Wong, Sarah King, Andrew A Bremer, Ronald M Krauss, James Hamilton, Peter J Havel
Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi
Journal of Lipid Research 2020 Mar;61(3):376-386. doi: 10.1194/jlr.RA119000423
PMID: 31919051

Yosten GL, Harada CM, Haddock C, Giancotti LA, Kolar GR, Patel R, Guo C, Chen Z, Zhang J, Doyle TM, Dickenson AH, Samson WK, Salvemini D. GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents. Journal of Clinical Investigation 2020 May 1;130(5):2587-2592. doi: 10.1172/JCI133270. PMID: 31999650

Samson WK, Carter JR, Yosten GLC. The 2019 new investigator award announcement. American Journal of Physiology Regulatory Integrative Comparative Physiology. 2020 Feb 1;318(2):R189-R190. doi: 10.1152/ajpregu.00362.2019. Epub 2020 Jan 3. PMID: 31899670

Samson WK. Looking back on seven years of Regulatory, Integrative and Comparative Physiology. American Journal of Physiology Regulatory Integrative Comparative Physiology 2020 Mar 1;318(3):R565-R566. doi: 10.1152/ajpregu.00017.2020. Epub 2020 Feb 12. PMID: 32048873

Haddock CJ, Almeida-Pereira G, Stein LM, Yosten GLC, Samson WK. A novel regulator of thirst behavior: phoenixin. American Journal of Physiology Regulatory Integrative Comparative Physiology. 2020 Jun 1;318(6):R1027-R1035. doi: 10.1152/ajpregu.00023.2020. Epub 2020 Apr 15. PMID: 32292064

Stockstill K, Wahlman C, Braden K, Chen Z, Yosten GL, Tosh DK, Jacobson KA, Doyle TM, Samson WK, Salvemini D. Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents. Pain. 2020 Jan;161(1):177-184. doi: 10.1097/j.pain.0000000000001697. PMID: 31490328

Yosten GLC. AJP- Regulatory, Integrative and Comparative Physiology: Looking toward the future. American Journal of Physiology Regulatory Integrative and Comparative Physiology 2020 Jul 1;319(1):R82-R86. doi: 10.1152/ajpregu.00104.2020. Epub 2020 May 6. PMID: 32374621

Sandip Mukherjee, Jake Haubner, Anutosh Chakraborty. Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases . Molecules. 2020 Mar 19;25(6):1403. doi: 10.3390/molecules25061403.PMID: 32204420

Nguyen TA and Nguyen AD. Applying Business Strategies to Establish Your Research Program. Current Protocols in Essential Laboratory Techniques. (2020) 20, e41. PMID: 33072244

Nguyen AD, Malmstrom TK, Niehoff ML, Aziz A, Miller DK, and Morley JE. Serum progranulin levels are associated with frailty in middle-aged individuals. PLoS One. (2020) 15, e0238877. PMID: 32886731

He L, de Souto Barreto P, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Vellas B, for the MAPT/DSA Group. Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults. Alzheimer's Research & Therapy. (2020) 12, 128. PMID: 33032662

He L, de Souto Barreto P, Virecoulon K, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Vellas B, for the MAPT/DSA Group. Cross-sectional and longitudinal associations between plasma neurodegenerative biomarkers and physical performance among community-dwelling older adults. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. (2020) glaa284. PMID: 33186456

Braden, K., L. A. Giancotti, Z. Chen, C. DeLeon, N. Latzo, T. Boehn, N. D'Cunha, B. M. Thompson, T. M. Doyle, J. G. McDonald, J. K. Walker, G. R. Kolar, C. K. Arnatt and D. Salvemini (2020). "GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain." Journal of Pharmacology and Experimental Therapeutics 375(2): 367-375 PMID 32913007, PMC7592849.

Doyle, T. M., M. R. Hutchinson, K. Braden, K. Janes, V. Staikopoulos, Z. Chen, W. L. Neumann, S. Spiegel and D. Salvemini (2020). "Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents." Journal of Neuroinflammation 17(1): 314 PMID 33092620, PMC7584082.

Doyle, T. M., K. Janes, Z. Chen, P. M. Grace, E. Esposito, S. Cuzzocrea, T. M. Largent-Milnes, W. L. Neumann, L. R. Watkins, S. Spiegel, T. W. Vanderah and D. Salvemini (2020). "Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents." Pain 161(9): 2107-2118 PMID 32301840, PMC7554181.

Doyle, T. M., T. M. Largent-Milnes, Z. Chen, V. Staikopoulos, E. Esposito, R. Dalgarno, C. Fan, D. K. Tosh, S. Cuzzocrea, K. A. Jacobson, T. Trang, M. R. Hutchinson, G. J. Bennett, T. W. Vanderah and D. Salvemini (2020). "Chronic Morphine-Induced Changes in Signaling at the A3 Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal." Journal of Pharmacology and Experimental Therapeutics 374(2): 331-341 PMID 32434943, PMC7372916

Farr, S. A., S. Cuzzocrea, E. Esposito, M. Campolo, M. L. Niehoff, T. M. Doyle and D. Salvemini (2020). "Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury." Journal of Neuroinflammation 17(1): 339 PMID 33183330, PMC7659122.

Ilari, S., C. Dagostino, V. Malafoglia, F. Lauro, L. A. Giancotti, A. Spila, S. Proietti, D. Ventrice, M. Rizzo, M. Gliozzi, E. Palma, F. Guadagni, D. Salvemini, V. Mollace and C. Muscoli (2020). "Protective Effect of Antioxidants in Nitric Oxide/COX-2 Interaction during Inflammatory Pain: The Role of Nitration." Antioxidants (Basel) 9(12) PMID 33339104, PMC7765556.

Ilari, S., L. A. Giancotti, F. Lauro, C. Dagostino, M. Gliozzi, V. Malafoglia, L. Sansone, E. Palma, M. Tafani, M. A. Russo, C. Tomino, M. Fini, D. Salvemini, V. Mollace and C. Muscoli (2020). "Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control." Pharmacology Research 157: 104851 PMID 32423865,

Ilari, S., L. A. Giancotti, F. Lauro, M. Gliozzi, V. Malafoglia, E. Palma, M. Tafani, M. A. Russo, C. Tomino, M. Fini, D. Salvemini, V. Mollace and C. Muscoli (2020). "Natural Antioxidant Control of Neuropathic Pain-Exploring the Role of Mitochondrial SIRT3 Pathway." Antioxidants (Basel) 9(11) PMID 33182469, PMC7698145.

Jacobson, K. A., L. A. Giancotti, F. Lauro, F. Mufti and D. Salvemini (2020). "Treatment of chronic neuropathic pain: purine receptor modulation." Pain 161(7): 1425-1441 PMID 32187120, PMC7305993.

Jung, Y. H., J. Yu, Z. Wen, V. Salmaso, T. P. Karcz, N. B. Phung, Z. Chen, S. Duca, J. M. Bennett, S. Dudas, D. Salvemini, Z. G. Gao, D. N. Cook and K. A. Jacobson (2020). "Exploration of Alternative Scaffolds for P2Y14 Receptor Antagonists Containing a Biaryl Core." Journal of Medicinal Chemistry 63(17): 9563-9589 PMID 32787142, PMC8040948.

Levine, A., E. Liktor-Busa, K. L. Karlage, L. Giancotti, D. Salvemini, T. W. Vanderah and T. M. Largent-Milnes (2020). "DAGLalpha Inhibition as a Non-invasive and Translational Model of Episodic Headache." Frontiers in Pharmacology 11: 615028 PMID 33584293, PMC7874129.

Lucarini, E., E. Coppi, L. Micheli, C. Parisio, A. Vona, F. Cherchi, A. M. Pugliese, F. Pedata, P. Failli, S. Palomino, J. Wahl, T. M. Largent-Milnes, T. W. Vanderah, D. K. Tosh, K. A. Jacobson, D. Salvemini, C. Ghelardini and L. Di Cesare Mannelli (2020). "Acute visceral pain relief mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels." Pain 161(9): 2179-2190 PMID 32379223,

Mufti, F., Y. H. Jung, L. A. Giancotti, J. Yu, Z. Chen, N. B. Phung, K. A. Jacobson and D. Salvemini (2020). "P2Y14 Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model." ACS Medicinal Chemistry Letters 11(6): 1281-1286 PMID 32551012, PMC7294700.

Musolino, V., M. Gliozzi, F. Scarano, F. Bosco, M. Scicchitano, S. Nucera, C. Carresi, S. Ruga, M. C. Zito, J. Maiuolo, R. Macri, N. Amodio, G. Juli, P. Tassone, R. Mollace, R. Caffrey, J. Marioneaux, R. Walker, J. Ehrlich, E. Palma, C. Muscoli, P. Bedossa, D. Salvemini, V. Mollace and A. J. Sanyal (2020). "Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease." Science Reports 10(1): 2565 PMID 32054943, PMC7018973.

Squillace, S., S. Spiegel and D. Salvemini (2020). "Targeting the Sphingosine-1-Phosphate Axis for Developing Non-narcotic Pain Therapeutics." Trends Pharmacological Science 41(11): 851-867 PMID 33010954,

Suresh, R. R., S. Jain, Z. Chen, D. K. Tosh, Y. Ma, M. C. Podszun, Y. Rotman, D. Salvemini and K. A. Jacobson (2020). "Design and in vivo activity of A3 adenosine receptor agonist prodrugs." Purinergic Signaling 16(3): 367-377 PMID 32720036, PMC7524976.

Guo C, Li J, Steinauer N, Wong M, Wu B, Dickson A, Kalkum M, Zhang J. Histone deacetylase 3 preferentially binds and collaborates with the transcription factor RUNX1 to repress AML1-ETO-dependent transcription in t(8;21) AML. Journal of Biological Chemistry. 2020 Mar 27;295(13):4212-4223. doi: 10.1074/jbc.RA119.010707. Epub 2020 Feb 18. PMID: 32071087; PMCID: PMC7105303.

Steinauer N, Guo C, Zhang J. The transcriptional corepressor CBFA2T3 inhibits all-trans-retinoic acid-induced myeloid gene expression and differentiation in acute myeloid leukemia. Journal of Biological Chemistry. 2020 Jul 3;295(27):8887-8900. doi: 10.1074/jbc.RA120.013042. Epub 2020 May 20. PMID: 32434928; PMCID: PMC7335779.

Banerjee S, Ghoshal S, Stevens JR, McCommis KS, Gao S, Castro-Sepulveda M, Mizgier ML, Girardet C, Kumar KG, Galgani JE, Niehoff ML, Farr SA, Zhang J, Butler AA. Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction. Journal of Biological Chemistry. 2020 Oct 2;295(40):13753-13768. doi: 10.1074/jbc.RA120.014381. Epub 2020 Jul 29. PMID: 32727846; PMCID: PMC7535914.

Griffin P, Sheehan PW, Dimitry JM, Guo C, Kanan MF, Lee J, Zhang J, Musiek ES. REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis. Elife. 2020 Dec 1;9:e58765. doi: 10.7554/eLife.58765. PMID: 33258449; PMCID: PMC7728439.

Lananna BV, McKee CA, King MW, Del-Aguila JL, Dimitry JM, Farias FHG, Nadarajah CJ, Xiong DD, Guo C, Cammack AJ, Elias JA, Zhang J, Cruchaga C, Musiek ES. Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis. Science Translational Medicine. 2020 Dec 16;12(574):eaax3519. doi: 10.1126/scitranslmed.aax3519. PMID: 33328329; PMCID: PMC7808313.

S. M. Kroger, L. Hill, E. Jain, A. Stock, P. J. Bracher, F. He, S. P. Zustiak, “Design of Hydrolytically Degradable Polyethylene Glycol Crosslinkers for Facile Control of Hydrogel Degradation”, Macromolecular Bioscience, 2020, 20(10), 2000085 PMID: 32734673

M. Choi, A. Blanco, S. Stealey, X. Duan, N. Case, S. Sell, M.F. Rai, S.P. Zustiak, “Micro-clotting of Platelet-Rich Plasma upon Loading in Hydrogel Microspheres Leads to Prolonged Protein Release and Slower Microsphere Degradation”, Polymers, 2020, 12(8), 1712 PMID: 32751604

E. Jain, M. Flanagan, S. Sheth, S. Patel, Q. Gan, B. Patel, A. Montano, S. P. Zustiak, “Biodegradable polyethylene glycol hydrogels for sustained release and enhanced stability of rhGALNS enzyme”, Drug Delivery and Translational Research, 2020, 1-12) PMID: 31994025

J. Peters, L. Vest, M. Schuelke, S. P. Zustiak, A. F. Hall, S. McBride-Gagyi, MicroCT Vascular Network Analysis Program: Development, Validation and Comparison to Manufacturer Software, Journal of Orthopaedic Research, 2020, 38(6), 1340-1350PMID: 31840849

Jain AK, Anand R, Lerret S, Yanni G, Chen J, Mohammad S, Doyle M, Telega G, Horslen S. Outcomes following liver transplantation in young infants: Data from the SPLIT registry. American Journal of Transplantation. 2020 Aug 7. PMID: 32767649.

Xanthakos S, Lavine J, Yates K, Schwimmer J, Molleston J, Rosenthal P, Murray K, Bos MB, Jain AK, Scheimann AO, Miloh T, Fishbein M, Behling C, Brunt E, Sanyal A, Tonascia J. Progression of Fatty Liver Disease in Children Receiving Standard of Care Lifestyle Advice. Gastroenterology. 2020 Jul 23; S0016-5085(20)34996-9. PMID: 32712103.

Guzman M, Manithody C, Krebs J, Denton C, Besmer S, Jain S, Villalona GS, Jain AK. Impaired gut-systemic signaling drives Total Parenteral Nutrition associated injury. Nutrients. 2020 May; 12(5): 1493. PMCID: PMC7284746

Manithody C, Denton C, Price A, Blomenkamp K, Patel Y, Welu A, Gilbert E, Madnawat H, Jain S, Villalona G, Jain AK. Development and validation of an ambulatory piglet model for short bowel syndrome with ileo-colonic anastomosis. Experimental Biology and Medicine (Maywood). 2020 Jun;245(12):1049-1057. PMID: 32264693

Manithody C, Van Nispen J, Murali V, Jain S, Samaddar A, Armstrong A, Jain AK. Role of Bile Acids and Gut Microbiota in Parenteral Nutrition Associated Injury. Journal of Human Nutrition 2020;4(1):286. PMID:32705087

Madnawat H, Welu A, Gilbert E, Taylor D, Jain S, Manithody C, Blomenkamp K, Jain AK. Mechanisms of Parenteral Nutrition Associated Liver and Gut Injury. Nutrion and Clinical Practice. 2020 Feb;35(1):63-71.PMID: 31872510 PMCID: PMC7014933

Welch RD, Billion C, Kameric A, Burris TP, Flaveny CA. Rev-erb alpha heterozygosity produces a dose-dependent phenotypic advantage in mice. PLoS One.2020 e0227720. PMID 32407314.

Lebenheim L, Booker SA, Derst C, Weiss T, Wagner F, Gruber C, Vida I, Zahm DS, Veh RW. A novel giant non-cholinergic striatal interneuron restricted to the ventral striatum coexpresses Kv3.3 potassium channel, parvalbumin, and the vesicular GABA transporter. Molecular Psychiatry. 2020 Nov 14. doi: 10.1038/s41380-020-00948-4. PMID: 33190145

Gordon-Fennell AG, Will RG, Ramachandra V, Gordon-Fennell L, Dominguez JM, Zahm DS, Marinelli M.The lateral preoptic area: a novel regulator of reward seeking and neuronal activity in the ventral tegmental area. Frontiers in Neuroscience. 2020 Jan 17;13:1433. PMID: 32009893

Rui Zhou, Xitong Dang, Randy S. Sprague, Jamal Mustafa, and Zhichao Zhou: Alteration of Purinergic Signaling in Diabetes: Focus on Vascular Function. Journal of Molecular and Cellular Cardiology 140: 1-9, 2020, PMID: 32057736.

Salas J, Morley JE, Scherrer JF, Floyd JS, Farr SA, Zubatsky M, Barthold D, Dublin S. Risk of Incident Dementia following Metformin Initiation compared with Non-initiation or Delay of Antidiabetic Medication Therapy. Pharmacoepidemiology and Drug Safety 2020 Jun;29(6):623-634. PMID: 32363681

Harding BN, Floyd JS, Scherrer JF, Salas J, Morley JE, Farr SA, Dublin S. Methods to identify dementia in the electronic health record: Comparing cognitive test scores with dementia algorithms. Healthcare. 2020 Jun;8(2):100430. PMID: 32553526

Farr SA, Cuzzocrea S, Esposito E, Campolo M, Niehoff ML, Doyle TM, Salvemini D. Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury. J Neuroinflammation. 2020 Nov 12;17(1):339. PMID: 33183330; PMCID: PMC7659122.

Green, A. T.; Moniruzzaman, M.; Cooper, C. J.; Walker, J. K.; Smith, J. C.; Parks, J. M.; Zgurskaya, H. I. Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold. Biochim Biophys Acta Gen Subj. 2020 June;1864(6):129546 PMID 32032658

Mansbach, R. A.; Leus, I. V.; Mehla, J.; Lopez, C. A.; Walker, J. K.; Rybenkov, V. V.; Hengartner, N. W.; Zgurskaya, H. I.; Gnanakaran, S. Machine Learning Algorithm Identifies an Antibiotic Vocabulary for Permeating Gram-negative Bacteria. J. Chem. inf. model. 2020 June 22; 60(6)2838-2847. PMID:32453589

Schoepke, E.; Haynes, K.M.; Avdagic, A.; Situala, S.; Billon, C.; Walker, J. K.; Burris, T. P.A Selective ERR𝝰/𝜸 Inverse Agonist, SLUPP-1072, inhibits the Warburg Effect and Induces Apoptosis in Prostrate Cancer Cells. ACS Chem Biol2020 Sept 18;15(9)2338-2345. PMID:32897058

Basta, J., L. Robbins, M.J. Prinsen, D.W. Griggs, and M. Rauchman. 2020. Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury. Physiological Reports 8(7):e14329. PMID: 32281744

Hayter EA, Castiaux AD, Martin RS. 3D-printed microfluidic device with in-line amperometric detection that also enables multi-modal detection. Analytic Methods. 2020 PMID: 32849919

Castiaux AD , Currens ER , Martin RS . Direct embedding and versatile placemonet of electrodes in 3D printed microfluidic devices. Analyst. 2020 May 7;145(9):3274-3282. PMID: 32242194