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Danielle H. Carpenter, M.D.

Professor, Division of Anatomic Pathology; Director, Gastrointestinal and Hepatic Pathology Fellowship Program; Director, autopsy service
Department of Pathology

Education

Fellowships
Liver and gastrointestinal pathology, Washington University School of Medicine
Surgical pathology, Washington University School of Medicine

Residencies
Anatomic and clinical pathology, Washington University School of Medicine
Anatomic and clinical pathology, Saint Louis University School of Medicine

Medical School
Saint Louis University School of Medicine

Practice Areas

  • Liver and gastrointestinal pathology
  • Surgical pathology
  • Autopsy
Courses Taught
  • Gastrointestinal and Hepatic Pathology Fellowship Program
  • Liver and GI pathology lectures - gastroenterology fellows
  • Pulmonary pathology lectures - pulmonary disease/critical care medicine fellows
  • Cardiovascular pathology module lecturer - medical students
  • Hepatobiliary and pancreas module lecturer - medical students
  • Gastrointestinal pathology elective course director - medical students
  • Anatomic pathology elective faculty - medical students
  • Career exploration in pathology faculty - medical students

Research Interests

  • Liver and gastrointestinal pathology
  • Lung pathology
  • Transplant pathology

Publications

Recent Publications

  • Lam TBN, Yates KP, Noon SL, Newton KP, Fishbein MH, Molleston JP, Xanthakos SA, Jain AK, Vos MB, Blondet NM, Mysore KR, Behling CA, Wilson LA, Schwimmer JB; and the NASH CRN [including Carpenter D]. Reclassifying pediatric NAFLD using the steatotic liver disease framework: A multicenter retrospective study from the NASH CRN. Hepatology. 2025 Oct 17:10.1097/HEP.0000000000001577. doi: 10.1097/HEP.0000000000001577. Epub ahead of print. PMID: 41104541; PMCID: PMC13070534.
  • Geerling E, Stone ET, Carpenter D, Dickson AM, Brien JD, Pinto AK. Metabolic syndrome enhances SARS-CoV-2 disease severity and reduces mRNA vaccine efficacy in a mouse model. bioRxiv [Preprint]. 2025 Jan 15:2025.01.15.633120. doi: 10.1101/2025.01.15.633120. PMID: 41030984; PMCID: PMC12478387.
  • Neuschwander-Tetri BA, Akbary K, Carpenter DH, Noureddin M, Alkhouri N. The Emerging Role of Second Harmonic Generation/Two Photon Excitation for Precision Digital Analysis of Liver Fibrosis in MASH Clinical Trials. J Hepatol. 2025 Apr 30:S0168-8278(25)00285-5. PMID: 40316054
  • Allende DS, Guy CD, Kleiner DE, Carpenter D, Gill RM, Cummings O, Contos M, Yeh M, Belt P, Wilson LA, Van Natta M, Behling C; NASH Clinical Research Network. Clinical associations of portal-based disease in MASLD: proposal of a new histological scoring system. Virchows Arch. 2025 Apr 10. PMID: 40210740
  • Allende DS, Cummings O, Sternberg AL, Behling CA, Carpenter D, Gill RM, Guy CD, Yeh MM, Gawrieh S, Sterling RK, Naggie S, Loomba R, Price JC, McLaughlin M, Hadigan C, Crandall H, Belt P, Wilson L, Chalasani NP, Kleiner DE; HIV NASH and NASH Clinical Research Groups. MASLD in people with HIV exhibits higher fibrosis stage despite lower disease activity than in matched controls. Aliment Pharmacol Ther. 2024 Nov;60(10):1351-1360. PMID: 39238213
  • Suri A, Zhang Z, Neuschwander-Tetri B, Lomas DA, Heyer-Chauhan N, Burling K, Loomba R, Brenner DA, Nagy R, Wilson A, Carpenter D, Blomenkamp K, Teckman J. Fibrosis, biomarkers and liver biopsy in AAT deficiency and relation to liver Z protein polymer accumulation. Liver Int. 2024 Dec;44(12):3204-3213. PMID: 39263815
  • Jain AK, Busgang SA, Gennings C, Yates KP, Schwimmer JB, Rosenthal P, Murray KF, Molleston JP, Scheimann A, Xanthakos SA, Behling CA, Carpenter D, Fishbein M, Neuschwander-Tetri BA, Tonasia J, Vos MB. Environmental toxicants modulate disease severity in pediatric metabolic dysfunction-associated steatohepatitis. J Pediatr Gastroenterol Nutr. 2024 Nov;79(5):943-953.PMID: 39282813
  • Fang Y, O'Leary C, Lowe H, Carpenter DH, Randall HB, Nazzal MD. A Unique Presentation of Diffuse Intraductal Papillary Mucinous Neoplasm of Bile Duct Successfully Treated With Orthotopic Liver Transplant and Pancreaticoduodenectomy Procedure: A Case Report. Cureus. 2024 Sep 25;16(9):e70177. PMID: 39463545
  • Kohut-Jackson AL, Goyal SD, Carpenter DH, Shahi J. Solitary Intracranial Plasmacytoma of the Brain Treated With Primary Radiation Therapy. Cureus. 2023 Dec 1;15(12):e49798. PMID: 38161554
  • Enwereuzo C, Carpenter D, Udofia D. Biliary Remnants in the Falciform Ligament: A Case Report. Int J Surg Pathol. 2023 Oct;31(7):1317-1318. PMID: 36503296.
  • Mukherjee S, Chakraborty M, Msengi EN, Haubner J, Zhang J, Jellinek MJ, Carlson HL, Pyles K, Ulmasov B, Lutkewitte AJ, Carpenter D, McCommis KS, Ford DA, Finck BN, Neuschwander- Tetri BA, Chakraborty A. Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo. Mol Metab. 2023 Sep;75:101767. PMID: 37429524.
  • Mukherjee S, Chakraborty M, Haubner J, Ernst G, DePasquale M, Carpenter D, Barrow JC, Chakraborty A. The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling.
  • Biomolecules. 2023 May 20;13(5):868. PMID: 37238737.
  • Gunasekar SK, Heebink J, Carpenter DH, Kumar A, Xie L, Zhang H, Schilling JD, Sah R. Adipose-targeted SWELL1 deletion exacerbates obesity- and age-related nonalcoholic fatty liver disease. JCI Insight. 2023 Mar 8;8(5):e154940. PMID: 36749637.
  • Gill RM, Allende D, Belt PH, Behling CA, Cummings OW, Guy CD, Carpenter D, Neuschwander-Tetri BA, Sanyal AJ, Tonascia J, Van Natta ML, Wilson LA, Yamada G, Yeh M, Kleiner DE; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). The nonalcoholic steatohepatitis extended hepatocyte ballooning score: histologic classification and clinical significance. Hepatol Commun. 2023 Feb 1;7(2):e0033 PMID: 36724127
  • Sharpe MC, Pyles KD, Hallcox T, Kamm DR, Piechowski M, Fisk B, Albert CJ, Carpenter DH, Ulmasov B, Ford DA, Neuschwander-Tetri BA, McCommis KS. Enhancing Hepatic MBOAT7 Expression in Mice With Nonalcoholic Steatohepatitis. Gastro Hep Adv. 2023;2(4):558-572 Epub 2023 Feb 23. PMID: 37293574.
  • Brotherton T, Al-Taee AM, Carpenter D, Cheesman AR. Metastatic Hepatocellular Carcinoma Masquerading as Acute Diverticulitis. ACG Case Rep J. 2022 Nov 24;9(11):e00913. PMID: 36447772.
  • Nwankwo EC Jr, Burton SJ, Brotherton T, Carpenter D, Qureshi K. Asymptomatic Hepatic Leiomyoma in an Immunocompetent Middle-Aged Woman. ACG Case Rep J. 2022 Nov 24;9(11):e00899. PMID: 36447767.
  • Worrall EB, Chhaparia A, Carpenter D, Neuschwander-Tetri BA. A Rare Cause of Upper Gastrointestinal Bleeding: Sarcina ventriculi. ACG Case Rep J. 2022 Aug 31;9(8):e00846. PMID: 36061245.
  • Nazzal M, Madsen EC, Armstrong A, van Nispen J, Murali V, Song E, Voigt M, Madnawat H, Welu A, Manithody C, Suri A, Krebs J, Gilbert E, Samaddar A, Blackall D, Carpenter D, Varma C, Teckman J, Jain AK. Novel NMP split liver model recapitulates human IRI and demonstrates ferroptosis modulators as a new therapeutic strategy. Pediatr Transplant. 2022 Mar;26(2):e14164. PMID: 34633130
  • Tian Y, Luu C, Carpenter DH, Montenegro G. A Unique Presentation of Metastatic Gallbladder Carcinoma. Case Rep Surg. 2021 Dec 16;2021:6455540. PMID: 34956686
  • Mukherjee S, Chakraborty M, Ulmasov B, McCommis K, Zhang J, Carpenter D, Msengi EN, Haubner J, Guo C, Pike DP, Ghoshal S, Ford DA, Neuschwander-Tetri BA, Chakraborty A. Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis. Mol Metab. 2021 Dec;54:101364. PMID: 34757046
  • Mandala A, Chen WJ, Armstrong A, Malhotra MR, Chavalmane S, McCommis KS, Chen A, Carpenter D, Biswas P, Gnana-Prakasam JP. PPARα Agonist Fenofibrate Attenuates Iron Induced Liver Injury in Mice by Modulating the Sirt3 and β-catenin Signaling. Am J Physiol Gastrointest Liver Physiol. 2021 Jul 21. PMID: 34287090
  • Brunt EM, Kleiner DE, Carpenter DH, Rinella M, Harrison SA, Loomba R, Younossi Z, Neuschwander-Tetri BA, Sanyal AJ; American Association for the Study of Liver Diseases NASH Task Force. NAFLD: Reporting Histologic Findings in Clinical Practice. Hepatology. 2021 May;73(5):2028-2038. PMID: 33111374
  • Allende DS, Gawrieh S, Cummings OW, Belt P, Wilson L, Van Natta M, Behling CA, Carpenter D, Gill RM, Kleiner DE, Yeh MM, Chalasani N, Guy CD; NASH Clinical Research Network.
  • Glycogenosis is common in nonalcoholic fatty liver disease and is independently associated with ballooning, but lower steatosis and lower fibrosis. Liver Int. 2021 May;41(5):996-1011. PMID: 33354866
  • Huang B, Mooser A, Carpenter D, Montenegro G, Luu C. A Rare Case of Pancreatic Endometriosis Masquerading as Pancreatic Mucinous Neoplasm. Case Rep Surg. 2021 Apr 23;2021:5570290. PMID: 34007507
  • Al-Taee A, Dinarvand P, Carpenter D, Al-Kaade S. Benign polypoid growth after endoscopic full-thickness resection. Gastrointest Endosc. 2020 Aug;92(2):432-433. PMID: 32109432.
  • Go A, Mehta M, Bihun T, Carpenter D, Ghani S. Metastatic Breast Cancer Presenting as a Gastric Primary with Linitis Plastica: a Case Report and Review of Literature. J Gastrointest Cancer. 2020 Jun;51(2):698-702. PMID: 32034640

Honors and Awards

  • Naomi Judd Award, Friends of the Saint Louis University Liver Center (2021)
  • John Kissane Faculty Teaching Award, Washington University School of Medicine (2016)
  • Louis Dehner Fellow Teaching Award, Department of Pathology, Washington University School of Medicine (2013)
  • Herbert B. Taylor Award, Department of Pathology, Saint Louis University School of Medicine (2007)
  • Alpha Omega Alpha, Saint Louis University School of Medicine (2007)
  • Phi Beta Kappa, Saint Louis University (2002)
  • Summa Cum Laude, Saint Louis University (2002)
  • Alpha Sigma Nu Jesuit Honor Society, Saint Louis University (2001)

Professional Organizations and Associations

  • American Society for Clinical Pathology (fellow)
  • College of American Pathologists (fellow)
  • United States and Canadian Academy of Pathology
  • Hans Popper Hepatopathology Society
  • Gastrointestinal Pathology Society
  • American Association for the Study of Liver Diseases
  • European Association for the Study of the Liver