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Anthony R. Anzel, Ph.D.

Assistant professor, Division of Medical Genetics
Department of Pediatrics

Assistant professor
Department of Biochemistry and Molecular Biology

Education

Postdoctoral Studies
Department of Human Genetics, University of Pittsburgh

Doctor of Philosophy
Physiology, Wayne State University

Bachelor of Science
Biomedical sciences, Grand Valley State University

Research Interests

The Anzell lab is interested in vascular biology and genetics with a specific focus on understanding the pathogenesis of autosomal dominant vascular disorder called Hereditary Hemorrhagic Telangiectasia (HHT). The lab employs a multi-disciplinary approach — including molecular genetics, cell biology, mechanobiology, quantitative image analysis, epidemiology, bioinformatics and artificial intelligence — to identify patients affected by disease; understand the underlying pathogenesis leading to vascular anomalies; and investigate the broader effects of vasculopathies on health outcomes in the general population.

Publications and Media Placements

  • Anzell AR, M White C, Diergaarde B, Carlson JC, Roman BL. Hereditary Hemorrhagic Telangiectasia Prevalence Estimates Calculated From GnomAD Allele Frequencies of Predicted Pathogenic Variants in ENG and ACVRL1. Circ Genom Precis Med. 2025 Oct;18(5):e005061. doi: 10.1161/CIRCGEN.124.005061. Epub 2025 Sep 18. PMID: 40964703; PMCID: PMC12741947. 
  • Garrett M. Fogo, Francisco J. Torres Torres, Reagan L. Speas, Anthony R. Anzell, Thomas H. Sanderson. Agent-based modeling of neuronal mitochondrial dynamics using intrinsic variables of individual mitochondria. iScience. 2025 Apr 8;28(5):112390. doi: 10.1016/j.isci.2025.112390. PMID: 40330889; PMCID: PMC12053660.
  • Anzell AR, Kunz AB, Donovan JP, Tran TG, Lu X, Young S, Roman BL. Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity. Angiogenesis. 2024 May 10. doi: 10.1007/s10456-024-09924-w. Epub ahead of print. PMID: 38727966. 
  • Cheng YW, Anzell AR, Morosky SA, Schwartze TA, Hinck CS, Hinck AP, Roman BL, Davidson LA. Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells. Cells. 2024 Feb 5;13(3):285. doi: 10.3390/cells13030285. PMID: 38334677; PMCID: PMC10854672. 
  • Anzell AR, Fogo GM, Gurm Z, Raghunayakula S, Wider JM, Maheras KJ, Emaus KJ, Bryson TD, Wang M, Neumar RW, Przyklenk K, Sanderson TH. Mitochondrial fission and mitophagy are independent mechanisms regulating ischemia/reperfusion injury in primary neurons. Cell Death Dis. 2021 May 12;12(5):475. doi: 10.1038/s41419-021-03752-2. PMID: 33980811; PMCID: PMC8115279.
  • Fogo GM*, Anzell AR*, Maheras KJ, Raghunayakula S, Wider JM, Emaus KJ, Bryson TD, Bukowski MJ, Neumar RW, Przyklenk K, Sanderson TH. Machine learning-based classification of mitochondrial morphology in primary neurons and brain. Sci Rep. 2021 Mar 4;11(1):5133. doi: 10.1038/s41598-021-84528-8. PMID: 33664336; PMCID: PMC7933342. * Co-first author