Neurosurgical Research

The Department of Neurological Surgery at Saint Louis University conducts research dedicated to improving patient outcomes through understanding the underlying causes of neurological disease, advancements in minimally invasive surgical techniques and assessment of patient outcomes.

SSM Health Saint Louis University Hospital is uniquely equipped with some of the most advanced neuroimaging techniques, including magnetoencephalography (MEG) and functional MRI.

Saint Louis University Advanced Neurosurgical Innovation Center (SANIC)

The Saint Louis University Advanced Neurosurgical Innovation Center (SANIC) was founded in 2008 by Dr. Richard Bucholz with a 5.3 million dollar grant from the Department of Defense to study traumatic brain injury (TBI) in military veterans. Since its inception, SANIC has added full-time research faculty with expertise in neuroimaging and neurobehavioral functioning.

Research at SANIC is focused on investigation of scientific and clinical use of technology to better understand and treat neurologic disorders. Current projects use functional neuroimaging (functional magnetic resonance imaging or diffusion tensor imaging), neurophysiological instruments (magnetoencephalography, or MEG), and neurobehavioral metrics (neuropsychological testing) to study neurologic disorders.

Along with eight other institutions, SANIC also participates in the Human Connectome Project headed by Washington University in St. Louis and the University of Minnesota which is one of the largest neuroscience studies ever funded by the National Institutes of Health. Future projects under development at SANIC are in the areas of neuroimaging, telemedicine and neurosurgical intervention.

The SANIC Team

  • Richard Bucholz, M.D., FACS, Vice Chairman for Research and Principle Investigator
  • Qian Jessie Luo, Ph.D., Consultant
  • Thomas M. Malone, Research Coordinator
  • Jeff Stout, Consultant
  • Virginia Wamser, Administrative Assistant

Traumatic Brain Injury Research Study

This study is no longer open to subject enrollment.

The purpose of the SANIC Traumatic Brain Injury Research Study is to determine whether the brains of persons with and without traumatic brain injury differ in a meaningful way when images of the brain are taken using three newer technologies. The hope is that the results of the study will help confirm the diagnosis of mild brain injuries and validate tools (help prove that diagnostic tools actually detect disease) for the diagnosis and treatment of Traumatic Brain Injuries (TBI).

The research is supported by a grant from the Department of Defense through the Congressionally Directed Medical Research Programs and is being conducted at Saint Louis University.

 

Recent Publications

Bolzenius, J.D., Salminen, L.E., Paul, R.H., & Roskos, P.T. (in press). Cognitive and self-reported psychological outcomes of blast-induced mild traumatic brain injury in veterans: A preliminary study. Applied Neuropsychology.

Gfeller, J.D. & Roskos, P.T. (in press). A comparison of insufficient effort rates, neuropsychological functioning and neuropsychiatric symptom reporting in military veterans and civilians with post-acute traumatic brain injury. Behavioral Sciences and the Law. http://onlinelibrary.wiley.com/doi/10.1002/bsl.2084/abstract

Luo, Q., Xu, D., Roskos, P. T., Stout, J., Kull, L., Cheng, X., Whitson, D., Boomgarden, E., Gfeller, J. D., & Bucholz, R. D. (2013) Complexity Analysis of Resting–state MEG Activity in Traumatic Brain Injury Patients. Accepted for publication Journal of Neurotrauma. http://www-ncbi-nlm-nih-gov.ezp.slu.edu/pubmed/?term=Luo+MEG+complexity

Stout, J., Bolzenius, J., Roskos, T., Osman, M., Frausto, R., Bucholz, R., & Mogul, D. (2013, 6-8 November). FMRI assessment of load based working memory in blast TBI and associated effects in FDG-PET signal. Paper accepted for presentation at The 6th International IEEE EMBS Neural Engineering Conference. San Diego, CA.