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Huazhang Guo, M.D., Ph.D.

Associate professor
Department of Pathology

Courses Taught

Workshops; Molecular pathology for residents (2019, 2020, 2023)

Education

Clinical Fellowship
Molecular genetic pathology, Mount Sinai Hospital

Residency
Anatomical/clinical pathology, New York Medical College at Westchester Medical Center

Postdoctoral Research
University of Tennessee Health Science Center

Doctor of Medicine
Fourth Military Medical University, China

Master of Medicine
Fourth Military Medical University, China

Bachelor of Medicine
Fourth Military Medical University, China

Practice Areas

  • Surgical pathology
  • Cytopathology
  • Molecular pathology

Research Interests

  • Molecular pathology
  • Digital pathology

Publications

Peer-Reviewed Articles     

  • Guo H, Ray RM, Johnson LR. RhoA stimulates IEC-6 cell proliferation by increasing polyamine-dependent Cdk2 activity. Am J Physiol Gastrointest Liver Physiol. 2003 Oct;285(4):G704-13. Epub 2003 Jun 19. PubMed PMID: 12816757.
  • Guo HZ, Yin Y, Wang WL, Zhang CS, Wang T, Wang Z, Zhang J, Cheng H, Wang HT. Sequence evolution of putative cytotoxic T cell epitopes in NS3 region of hepatitis C virus. World J Gastroenterol. 2004 Mar 15;10(6):847-51. PubMed PMID: 15040030.
  • Wang Z, Li Q, Huang GS, Liu SJ, Guo HZ, Zhang J, Cheng H, Xu J, Barenboim-Stapleton L, Ried T. Clinical report of congenital lymphatic malformations and partial gigantism of the hands associated with a heterogeneous karyotype. Am J Med Genet A. 2005 Jan 1;132A(1):106-7. PubMed PMID: 15472995.
  • Ray RM, Guo H, Patel M, Jin S, Bhattacharya S, Johnson LR. Role of myosin regulatory light chain and Rac1 in the migration of polyamine-depleted intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G983-95. Epub 2006 Dec 14. PubMed PMID: 17170026.
  • Bhattacharya S, Guo H, Ray RM, Johnson LR. Basic helix-loop-helix protein E47-mediated p21Waf1/Cip1 gene expression regulates apoptosis of intestinal epithelial cells. Biochem J. 2007 Oct 15;407(2):243-54. PubMed PMID: 17617061.
  • Khurana S, Tomar A, George SP, Wang Y, Siddiqui MR, Guo H, Tigyi G, Mathew S. Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Exp Cell Res. 2008 Feb 1;314(3):530-42. Epub 2007 Nov 12. PubMed PMID: 18054784.
  • Guo H, Makarova N, Cheng Y, E S, Ji RR, Zhang C, Farrar P, Tigyi G. The early-and late stages in phenotypic modulation of vascular smooth muscle cells:differential roles for lysophosphatidic acid. Biochim Biophys Acta. 2008 Sep;1781(9):571-81. doi: 10.1016/j.bbalip.2008.06.003. Epub 2008 Jun 13. PubMed PMID: 18602022.
  • Khandoga AL, Fujiwara Y, Goyal P, Pandey D, Tsukahara R, Bolen A, Guo H, Wilke N, Liu J, Valentine WJ, Durgam GG, Miller DD, Jiang G, Prestwich GD, Tigyi G, Siess W. Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin. Platelets. 2008 Sep;19(6):415-27. doi: 10.1080/09537100802220468. PubMed PMID: 18925509.
  • E S, Lai YJ, Tsukahara R, Chen CS, Fujiwara Y, Yue J, Yu JH, Guo H, Kihara A, Tigyi G, Lin FT. Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect. J Biol Chem. 2009 May 22;284(21):14558-71. doi: 10.1074/jbc.M900185200. Epub 2009 Mar 17. PubMed PMID: 19293149.
  • Cheng Y, Makarova N, Tsukahara R, Guo H, Shuyu E, Farrar P, Balazs L, Zhang C, Tigyi G. Lysophosphatidic acid-induced arterial wall remodeling: requirement of PPARgamma but not LPA1 or LPA2 GPCR. Cell Signal. 2009 Dec;21(12):1874-84. doi: 10.1016/j.cellsig.2009.08.003. Epub 2009 Aug 23. PubMed PMID: 19709640.
  • Tsukahara T, Tsukahara R, Fujiwara Y, Yue J, Cheng Y, Guo H, Bolen A, Zhang C,Balazs L, Re F, Du G, Frohman MA, Baker DL, Parrill AL, Uchiyama A, Kobayashi T, Murakami-Murofushi K, Tigyi G. Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid. Mol Cell. 2010 Aug 13;39(3):421-32. doi: 10.1016/j.molcel.2010.07.022. PubMed PMID: 20705243.
  • Guo H, Birsa J, Farahani N, Hartman DJ, Piccoli A, O'Leary M, McHugh J, Nyman M, Stratman C, Kvarnstrom V, Yousem S, Pantanowitz L. Digital pathology and anatomic pathology laboratory information system integration to support digital pathology sign-out. J Pathol Inform. 2016 May 4;7:23. doi: 10.4103/2153-3539.181767. eCollection 2016 May 4. PubMed PMID: 27217973.
  • Brożyna AA, Guo H, Yang SE, Cornelius L, Linette G, Murphy M, Sheehan C, Ross J, Slominski A, Carlson JA. TRPM1 (melastatin) expression is an independent predictor of overall survival in clinical AJCC stage I and II melanoma patients. J Cutan Pathol. 2017 Apr;44(4):328-337. doi: 10.1111/cup.12872. Epub 2017 Jan 26. PubMed PMID: 27987328.
  • TRPM1 (melastatin) expression is an independent predictor of overall survival in clinical AJCC stage I and II melanoma patients. Brożyna AA, Guo H, Yang SE, Cornelius L, Linette G, Murphy M, Sheehan C, Ross J, Slominski A, Carlson JA. J Cutan Pathol. 2017 Apr;44(4):328-337
  • Pantanowitz L, Liu C, Huang Y, Guo H, Rohde GK. Impact of Altering Various Image Parameters on Human Epidermal Growth Factor Receptor 2 Image Analysis Data Quality. J Pathol Inform. 2017 Sep 7;8:39
  • Williams EE, Patel N, Guo H, Hurley MY, Abate MS. Kikuchi-Fujimoto disease diagnosed by correlating skin and lymph node biopsies. JAAD Case Rep. 2019 Apr 5(5):416-418
  • Muzaffar R, Vacca F, Guo H, Mhapsekar R, Osman MM. Pediatric Nasopharyngeal Carcinoma as Seen on 18F-FDG PET/CT. Front Oncol. 2019 Mar 6;9:110
  • Siddiqui Z, Maldonado J, Grojean J, Ye F, Zhang D, Longtine J, Ahn TH, Guo H. Rchimerism: An R-Package for automated chimerism data analysis. J Mol Diag. 2020 Jan 22(1): 21-29
  • Hanson J, Etemady-Deylamy A, Frisby J, D'Addario J, Smeds M, Chamberland R, Guo H, Abate G. Femoral artery aneurysm with large hematoma from Pasteurella: case report and literature review. BMC Infect Dis. 2022 Feb 21;22(1):170
  • Duan A, Guo K, Guo H. Automate cancer synoptic reporting with HyperText Markup Language (HTML) and JavaScript. Am J Clin Pathol. 2025 Jan 1:aqae173. doi: 10.1093/ajcp/aqae173. Epub ahead of print. PMID: 39742872.
  • Guo J, Grojean J, Guo H. ARMSprimer3: An open-source primer design Python program for amplification refractory mutation system PCR (ARMS-PCR). J Pathol Inform. 2025 Apr 15;17:100442. doi: 10.1016/j.jpi.2025.100442. PMID: 40421167; PMCID: PMC12104711.

Invited Review Articles
  • Guo H, Carlson JA, Slominski A. Role of TRPM in melanocytes and melanoma. Exp Dermatol. 2012 Sep;21(9):650-4. doi: 10.1111/j.1600-0625.2012.01565.x. PubMed PMID: 22897572.
  • Guo J, Starr D, Guo H. Classification and review of free PCR primer design software. Bioinformatics. 2021 Apr;36(22-23):5263-8. doi: 10.1093/bioinformatics/btaa910. PubMed PMID: 33104196.
  • Zhang X, Niyazi S, Guo H, Zhang L. Mimickers and associated neoplasms of Castleman disease. Journal of Clinical and Translational Pathology. 2025 vol. 5(1): 20-9. doi: 10.14218/JCTP.2024.00047

Honors and Awards

  • CAPA Service Award (2026)

Professional Organizations and Associations

  • College of American Pathologists (member)
  • Chinese Amerian Pathologists Association (lifetime member)
  • IT committee chair, CAPA (2025-2026)
  • House of Delegates of CAP (member, 2023-2025)

Community Work and Service

  • Volunteer photographer for youth sports