Division of Pediatric Hematology and Oncology
Saint Louis University School of Medicine's Division of Hematology and Oncology provides a full range of clinical services to children and adolescents with blood disorders and cancer.
Healing Hope for Children
The Division of Pediatric Hematology and Oncology is committed to advancing the care of children by bridging basic science research with clinical research programs. It’s an active participant in several childhood cancer research networks, and is a co-founder of the Beat Childhood Cancer Consortium. It contributes to national and sponsored studies for hemostasis and sickle cell disease.
Divisional specialists treat patients at the Costas Center in SSM Health Cardinal Glennon Children’s Hospital, where they also train undergraduate and graduate medical students.
Specialty Care
The division has seven distinct clinical programs dedicated to the following areas of care:
- Stem cell transplants
- Neuro-oncology
- Bleeding and clotting disorders
- Inherited blood disorders
- Bone and soft tissue cancers
- Blood component donation and treatment
- Long-term care for cancer survivors
Pediatric Hematology and Oncology Research
- Umbilical cord blood transplantation
- Acute leukemias and lymphomas
- Soft tissue sarcomas
- Using high-risk tumor profiling to guide therapy
- Stem cell transplantation
- Pediatric palliative and end-of-life care
- Acute and long-term toxicities of cancer-directed therapies
- Pediatric hemostasis and thrombosis
- Cellular therapy and oncolytic virotherapy in pediatric brain tumors
- Clinical trials for improving:
- Sickle cell disease outcomes
- Solid tumor treatment
- Bleeding disorder treatments
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- Puetz J, Cheng D. Descriptive analysis of bleeding symptoms in haemophilia carriers enrolled in the ATHNdataset. Haemophilia 2021; 27: 6: 1045-1050.
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- Kraveka JM, Lewis EC, Bergendahl G, Ferguson W, Oesterheld J, Kim E, Nagulapally AB, Dykema KJ, Brown VI, Roberts WD, Mitchell D, Eslin D, Hanson D, Isakoff MS, Wada RK, Harrod VL, Rawwas J, Hanna G, Hendricks WPD, Byron SA, Snuderl M, Serrano J, Trent JM, Saulnier Sholler GL. A pilot study of genomic-guided induction therapy followed by immunotherapy with difluoromethylornithine maintenance for high-risk neuroblastoma. Cancer Rep (Hoboken). 2022 Nov;5(11):e1616. doi: 10.1002/cnr2.1616. Epub 2022 Mar 31. PMID: 35355452; PMCID: PMC9675391.
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- Ferguson, WS. A better way to detect iron deficiency? J Pediatr 2021 Dec; 239:2.
- Ferguson, WS. Neurodevelopmental Consequences of Neonatal Thrombocytopenia. J Pediatr 2023; 258:113555.
- Ferguson, WS. Preventing Thrombosis in Children with MIS-C. J Pediatr 2023 262:113766.
- Ghajar-Rahimi G, Kang KD, Totsch SK, Gary S, Rocco A, Blitz S, Kachurak K, Chambers MR, Li R, Beierle E, Bag AK, Johnston J, Markert J, Bernstock JD, Friedman GK. Clinical advances in oncolytic virotherapy for pediatric brain tumors. Pharmacol Ther. 2022
- Jones A, Rocco A, Lamb LS, Friedman GK, Hjelmeland AB. Regulation of NKG2D stress ligands and its relevance in cancer progression. Cancers. 2022.
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- Truscott J, Wang V. Fleisher & Ludwig's 5-Minute Pediatric Emergency Medicine Consult, 3rd edition. “Cancer Treatment Complications.”. pending publication
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- Truscott J, Guan X, Fury H, Atagozli T, Metwali A, Liu W, Li Y, Li RW, Elliott DE, Blazar BR, Ince MN. After Bone Marrow Transplantation, the Cell-Intrinsic Th2 Pathway Promotes Recipient T Lymphocyte Survival and Regulates Graft-versus-Host Disease. Immunohorizons. 2023 Jun 1;7(6):442-455. doi: 10.4049/immunohorizons.2300021.
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- Oesterheld JE, Bergendahl G, Berry DA, Lorenzi E, Clinch T, Kraveka JM, Ferguson W, Brown VI, Eslin D, Hanson D, Harrod VL, Isakoff M, Mitchell D, Wada R, Zage PE, Saulnier Sholler GL. Matched external control analysis of event-free survival (EFS) in patients with high-risk neuroblastoma (HRNB) receiving eflornithine (DFMO) maintenance. American Society of Clinical Oncology Annual Meeting, June 2022.
- Oesterheld JE, Bergendahl G, Berry DA, Lorenzi E, Clinch T, Kraveka JM, Ferguson W, Brown VI, Eslin D, Hanson D, Harrod VL, Isakoff M, Mitchell D, Wada R, Zage PE, Saulnier Sholler GL. Comparison of event free survival (EFS) in high-risk neuroblastoma (HRNB) patients receiving enflornithine (DFMO) maintenance to an external control immunotherapy study database. International Society of Paediatric Oncology (SIOP) annual meeting, Sept-Oct 2022.
- Saulnier Sholler GL, Kraveka J, Bergendahl G, Lewis E, Ferguson W, Nagulapally A, Dykema K, Brown V, Isakoff M, Junewick J, Mitchell D, Eslin D, Harrod V, Roberts W, Oesterheld J, Wada R, Rawwas J, Pastakia D, Ginn K, Saab R, Bielamowicz K, Glover J, Chang E, Hanna G, Enriquez D, Izatt T, Halperin R, Byron S, Hendricks W, Trent J. Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial. American Association for Cancer Research (AACR) Annual Meeting April 2023.
- Kraveka J, Ferguson W, Bergendahl G, Lewis EC, Nagulapally AB, Dykema K, Brown VI, Isakoff MS, Junewick J, Mitchell D, Rawwas J, Roberts W, Eslin D, Oesterheld J, Wada RK, Pastakia D, Harrod V, Ginn K, Saab R, Bielamowicz K, Glover J, Chang E, Hanna GK, Enriquez D, Izatt T, Halperin RF, Byron SA, Hendricks WPD, Trent JM, Saulnier Sholler GL. Molecular-guided therapy for the treatment of relapsed neuroblastoma: A Beat Childhood Cancer Research Consortium Trial. Advances in Neuroblastoma Research Annual Meeting May 2023.
- Oesterheld J, Saulnier Sholler G, Ferguson W, Bergendahl G, Kraveka JM, Clinch T, Lorenzi E, Berry DA, Wada RK, Isakoff MS, Eslin DE, Brown VI, Zage P, Harrod VL, Mitchell DS, Hanson D. Confirmation of Event Free Survival (EFS) in High-Risk Neuroblastoma (HRNB) Patients Receiving Eflornithine (DFMO) Maintenance Treatment based on a Retrospective, Blinded Independent Central Review (BICR) of Imaging during Long-Term Follow-Up. American Society of Clinical Oncology Annual Meeting, June 2023.
- Bergendahl G, Kraveka J, Ferguson W, Oesterhald J, Clinch T, Gullo KL, Staines H, Sholler G. EFS and OS in Study 3b Patients with High-Risk Neuroblastoma Receiving Eflornithine (DFMO) Maintenance Treatment with Matched External Controls. Association of Pediatric Hematology/Oncology Nurses (APHON) Annual Conference September 2023.
- Kraveka J, Oasterheld J, Ferguson W, Bergendahl G, Clinch T, Staines H, Sholler G. MICE Sensitivity Analysis of Event Free Survival in High-Risk Neuroblastoma Patients Receiving Eflornithine (DFMO) Maintenance Treatment with Matched External Controls. International Society of Paediatric Oncology (SIOP) annual meeting, October 2023.
- Kraveka J, Berg A, Bergendahl G, Ferguson W, Ginn K, Mitchell D, Wada R, Brown V, Isakoff M, Moore A, SaulnierSholler G. End of Induction Response Correlates with Clinical Outcome in High-Risk Neuroblastoma Patients. Annual meeting of American Society of Pediatric Hematology/Oncology, Seattle, WA, April 2024
- Clinch T, Ferguson W, Kraveka J, Staines H, Bergendahl G, Berg A, SaulnierSholler G. Assessment of Household Poverty Exposure in Patients with HRNB Receiving DFMO Maintenance Treatment. Annual meeting of American Society of Pediatric Hematology/Oncology, Seattle, WA, April 2024.
- Saulnier Sholler GL, Ferguson W, Bergendahl G, Clinch T, Kraveka JM. Survival Outcomes in High-Risk Neuroblastoma (HRNB) Patients in Remission after Relapsed or Refractory Treatment Receiving Eflornithine (DFMO) Maintenance. Submitted to American Society of Clinical Oncology Annual Meeting, June 2024.
- Bergendahl G, Steinbrecher J, Smith L, Lincoln J, Moore A, Clinch T, Ferguson W, Kraveka JM, Saulnier Sholler G. Clinical Administration of DFMO (Eflornithine) is Flexible in Pediatric Patients with HRNB. Submitted to Association of Pediatric Hematology/Oncology Nurses (APHON) Annual Conference September 2024.
- Kraveka J, Ferguson W, Bergendahl G, Clinch T, Moore A, Eslin D, Brown V, Roberts W, Wada R, Mitchell D, Zage P, Rawwas J, Saulnier Sholler G. Survival Outcomes in Patients with High-Risk Neuroblastoma (HRNB) in Remission After Relapsed or Refractory Treatment Receiving Eflornithine (DFMO) Maintenance. Submitted to International Society of Paediatric Oncology (SIOP) annual meeting, October 2024.
- Moore A, Lincoln J, Bergendahl G, Treadway S, Halley N, Caran E, Ambar N, Nagulapally A, Draveka J, Ferguson W, Saulnier Sholler G. Use of Eflornithine (DFMO) in High Risk Neuroblastoma (HRNB) Patients from Brazil: A Promising Experience for the Future. Submitted to International Society of Paediatric Oncology (SIOP) annual meeting, October 2024.
- Kraveka JM, Ferguson W, Bergendahl G, Clinch T, Moore A, Lincoln J, Wada RK, Isakoff MS, Eslin DE, Brown VI, Roberts W, Harrod VL, Mitchell DS, Saulnier Sholler G. Survival Outcomes in Patients with High-Risk Neuroblastoma (HRNB) Receiving Eflornithine (DFMO) Maintenance Treatment with Matched External Controls: Subgroup Analysis on Geographic Region. Oral presentation at the International Society of Paediatric Oncology (SIOP) annual meeting, October 2024.
- Saulnier Sholler G, Ferguson W, Bergendahl G, Clinch T, Staines H, Berg A, Kraveka JM. Assessment of Household Poverty Exposure in Patients with High-Risk Neuroblastoma (HRNB) Receiving Eflornithine (DFMO) Maintenance Treatment. Submitted to International Society of Paediatric Oncology (SIOP) annual meeting, October 2024.
- Bergendahl G, Kraveka JM, Ferguson W, Brown V, Huang M, Steinbrecher J, Moore A, Lincoln J, Salnier Sholler, G. Safety Comparison of Two Different Dosing Regimens for Oral Eflornithine (DFMO) in Pediatric Solid Tumors. Submitted to the American Society of Pediatric Hematology-Oncology annual meeting, May 2025.
- Kraveka JM, Bergendahl G, Ferguson W, Berg A, Wada RK, Tiera P, Bielamowicz K, Michon B, Alva E, Steinbrecher J, Moore A, Saulnier Sholler G. Safety of Naxitimab + Granulocyte Macrophage Colony Stimulating (GM-CSF) in Combination with Induction Chemotherapy in High-Risk Neuroblastoma (HRNB). Submitted to the American Society of Pediatric Hematology-Oncology annual meeting, May 2025.
- Bergendahl G, Ferguson W, Kraveka JM, Moore A, Clinch T, Saulnier Sholler G. Survival Outcomes in Patients with HRNB in Remission 7 Years After Starting DFMO Maintenance Therapy. Submitted to the American Society of Pediatric Hematology-Oncology annual meeting, May 2025.
- Bergendahl G, Kraveka JM, Ferguson W, Brown V, Huang MAC, Steinbrecher J, Moore A, Lincoln J, Saulnier Sholler G. Safety Comparison of Two Different Dosing Regimens for Oral Eflornithine (DFMO) in Pediatric Solid Tumors. Submitted to the Advances in Neuroblastoma Research Association meeting, May 2025.
- Kraveka JM, Bergendahl G, Ferguson W, Berg A, Wada RK, Tiera P, Bielamowicz K, Michon B, Alva E, Steinbrecher J, Moore A, Saulnier Sholler G. Safety of Naxitimab + Granulocyte Macrophage Colony Stimulating (GM-CSF) in Combination with Induction Chemotherapy in High-Risk Neuroblastoma (HRNB). Submitted to the Advances in Neuroblastoma Research Association meeting, May 2025.
- Saulnier Sholler G, Lincoln J, Bergendahl G, Ferguson W, Brown V, Steinbrecher J, Moore A, Kraveka JM. Safety and ALK Inhibitors in Combination with Eflornithine (DFMO) in High-Risk Neuroblastoma (HRNB). Submitted to the Advances in Neuroblastoma Research Association meeting, May 2025.
- Berg A, Kraveka J, Bergendahl G, Gerguson W, Ginn K, Mitchell D, Wada RK, Brown VI, Isakoff MS, Moore A, Saulnier Sholler G. End-of-Induction Response as a Surrogate Endpoint for Overall Survival in High-Risk Neuroblastoma. Submitted to the Advances in Neuroblastoma Research Association meeting, May 2025.
- Ferguson W, Kraveka JM, Bergendahl G, Moore A, Clinch T, Saulnier Sholler G. Survival Outcomes in Patients with High-Risk Neuroblastoma on Eflornithine (DFMO) Maintenance: Matched External Control Analysis at 7-Year Follow-Up. Submitted to the Advances in Neuroblastoma Research Association meeting, May 2025.
- Bergendahl G, Steinbrecher J, Smith L, Treadway S, Kraveka JM, Ferguson W, Brown V, Saulnier Sholler G. Safety Comparison of Two Different Dosing Regimens for Oral Eflornithine (DFMO) in Pediatric Solic tumors. Submitted to Association of Pediatric Hematology/Oncology Nurses (APHON) Annual Conference September 2025.
- Harrod V, Brown V, Ferguson W, Kraveka J, Mitchell M, Eslin D, Wada R, Roberts W, Bergendahl G, Lincoln J, Steinbrecher J, Moore A, Treadway S, Gollamudi VRM, Bansai S, Ambar N, Caran E, Saulnier Sholler G. Impact of Eflornithine Maintenance Therapy on Survival in high Risk Neuroblastoma Patients from China, India and Brazil. Submitted to the International Society of Paediatric Oncology (SIOP) annual meeting, October 2025.
- Moore A, Nagulapally A, Kraveka J, Ferguson W, Brown V, Harrod V, Eslin D, Glover J, Mitchell M, Michael M, Hanna G, Dovat S, Saulnier Sholler G. Pediatric Consortium Development and Oversight of an International Molecular Tumor Board. Submitted to the International Society of Paediatric Oncology (SIOP) annual meeting, October 2025.
- Saulnier Sholler G, Lincoln J, Bergendahl G, Ferguson W, Brown V, Moore A, Steinbrecher J, Kraveka J. Safety of Alk Inhibitors in Combination with Eflornithine (DFMO) in High-Risk Neuroblastoma (HRNB). Submitted to the International Society of Paediatric Oncology (SIOP) annual meeting, October 2025.
Leili Dolatshahi, M.D.
- “Severe Warm Autoimmune Hemolytic Anemia in a 7-month-old Infant Associated With a Mycoplasma Pneumoniae Infection” (Journal of Pediatric Hematology Oncology, November 2017
- SCHOLARSHIP
- Dissemination and Implementation of Stroke Prevention Looking at the Care Environment (DISPLACE Study), Site Investigator (July 2017 – now)
- Sickle cell and hemoglobinopathies of Illinois State, Principal Investigator (July 2017 – now)
- Missouri Department of Health and Senior Services Pediatric Hemoglobinopathy Resource Center Service, Principal Investigator (June 2017 – now)
William Ferguson, M.D.
- Pediatric Research Colloquium: “DFMO (Eflornithine) as Maintenance
Therapy for High-Risk Neuroblastoma” - Introduction to Academic Medicine: “Informed Consent and the Ethics of Clinical Research”
Maggie Cupit-Link, M.D.
- Treatment of High-Risk Neuroblastoma Using Dinutuximab Chemoimmunotherapy in All Cycles of Induction. Advances in Neuroblastoma. Amsterdam, Netherlands. 2023
- Predictors of Nausea During Early Treatment in Children with Acute Lymphoblastic Leukemia. American Society of Pediatric Hematology Oncology. Fort Worth, TX. 2023
- Treatment of High-Risk Neuroblastoma Using Dinutuximab Chemoimmunotherapy in All Cycles of Induction. American Society of Pediatric Hematology Oncology. Fort Worth, TX. 2023
Abbey Rocco, M.D.
- Rocco, A. Targeting Pediatric Malignant Brain Tumors with Chlorotoxin Chimeric Antigen Receptor Gamma Delta T Cells. UAB Department of Pediatric Hematology Oncology Division Research Presentation. Birmingham, AL December 07, 2021
- Rocco, A. Targeting Pediatric Malignant Brain Tumors with Chlorotoxin Chimeric Antigen Receptor Gamma Delta T Cells. UAB Department of Pediatric Hematology Oncology Division Research Presentation. Birmingham, AL August 09, 2022
- Rocco, A. Targeting Pediatric Malignant Brain Tumors with MGMT modified Gamma Delta T Cells. UAB Department of Pediatric Hematology Oncology Division Research Presentation. Birmingham, AL March 21, 2023
John Puetz M.D.
- Hemophilia Carrier, Regional Meeting, New Orleanes, 2024
- Hemophilia Gene Therapy, Grand Rounds. Columbia, Missouri. 2023
- Hemophilia Gene Therapy, Project ECHO. Houston, Texas. 2022
- Hemostasis Update, Grand Rounds, St. Louis, Missouri. 2021
- Microbleeds, Regional Meeting. Lansing, Michigan. 2020