Pediatric Research

Pediatric Research
Pediatric Research

Faculty/Degree/RankingResearch Interests
Ayoob Ali MD, MPD, MBA, CPE
Associate Professor
Department of Pediatrics
Research Interests:
I am currently working on Neonatal Laryngeal Mask Airway (NLMA). A new device to be used in premature and term infants for neonatal resuscitation or establishing difficult airway in neonates. This device can also be used to administer Surfactant without endotracheal intubation. Currently there is no device available to administer surfactant into premature neonates without Endotracheal intubation. Neonatal Laryngeal Mask Airway (NLMA) is Non-invasive way to administer surfactant in neonates.

Keywords: NLMA, Neonatal Laryngeal Mask Airway, Laryngeal Mask Airway, RDS, Neonatal Resuscitation
Stephen R. Braddock, MD
Professor
Department of Pediatrics
Research Interests:
My research interests and goals are to investigate the prevalence of, consequences including dysmorphology and longitudinal variation of prenatal teratogen exposures and birth defects.

Keywords: Dysmorphology/Syndrome Delineation, Fetal Alcohol Syndrome (FAS), Teratology
Matthew A. Broom, MD
Associate Professor
Pediatrics (Clinical Educator)
Research Interests:
a) Improving medical education, specifically related to improving provider-patient communication and the teaching of professionalism b) Broadening ways to embrace technology (e.g. text messaging) in medical education and patient care c) Improving the diagnosis and treatment of postpartum depression within the pediatric clinic environment

Keywords: Medical education, professionalism, postpartum depression, text messaging
Marianne Dunstan MD
Adjunct Associate Professor
Pediatrics
Clinical Track
Division of Adolescent Medicine
Research Interests:
Medical / Nutritional issues within juvenile justice programs Currently advising an RD graduate student studying nutrition in juvenile jail settings

Keywords: Juvenile Justice, Vitamin D, Lipids, Obesity, Fitness
Robert E Fleming, MD
Professor
Pediatrics and Biochemistry & Molecular Biology (tenure)
Research Interests:
Our laboratory investigates the molecular mechanisms regulating cellular and systemic iron metabolism, primarily using cell culture and genetically manipulated murine model systems. These investigations include examining the potential for exogenous transferrin to modify certain inflammatory conditions, iron overload states (hemochromatosis), and iron-loading anemias (e.g. thalassemia).

Keywords: iron, hepcidin, hemochromatosis, anemia, transferrin
Robert Flood, MD
Professor
Clinical Educator
Director, Division of Emergency Medicine
Research Interests:
As division director, I help oversee all of the research in the division. My personal research interests include 1) Disaster Preparedness; 2) Acute Reactive Airway Disease; 3) Wound Care; 4) Trauma care; 5) ED Flow/Quality Assurance/Quality Improvement.

Keywords: Asthma, Quality, Lacerations, Disaster, Trauma
Jeremy S. Garrett, MD
Professor
Clinical Educator
Department of Pediatrics
Research Interests:
Research interests in simulation as a tool for both medical learning and building a highly efficient medical team. Also interests in use of innovative game format for medical learning. Previous basic science research interests in production and release of cellular growth factors in the pathogenesis of and recovery from critical illness.

Keywords: Simulation, Medical Education, team building, growth factors
James M. Gerard, MD
Professor
Clinical Educator
Research Interests:
Interest in studying the use of simulation to train physicians in cognitive and psychomotor pediatric emergency medicine skills. Beginning an ONR funded project to develop and validate a virtual pediatric simulator to train physicians on high-stakes pediatric emergency medicine scenarios. 

Keywords: Simulation; Pediatric Emergency Medicine; Virtual Reality
Donna R Halloran, MD, MSPH
Associate Professor
Pediatrics
Clinical Educator

Research Website
Research Interests:
Dr. Halloran is interested in the effects of pregnancy on infant and child health whether it is obesity in pregnancy or late preterm delivery. She utilizes birth certificates and insurance claims data to assess outcomes.

Keywords: infant outcomes, child outcomes, pregnancy and obesity, late preterm
Meg Hefner, MS
Genetic Counselor
Adjunct Associate Professor of Pediatrics
Division of Medical Genetics
Research Interests:

CHARGE Syndrome Clinical Database Project (CSCDP). We have developed an extensive clinical database within Qualtrics (a SLU-contracted survey tool). Parents or adults with CHARGE syndrome can enter data in the 12 sections of clinical information via a web-based survey tool. Our intent is to collect as much information as possible on a very large cohort for local "data mining" and as an adjunct to others doing research on CHARGE syndrome. Provisions are in place to share data with other researchers.

Keywords: CHARGE syndrome, clinical database, genetic syndrome, cranial nerves
Noah Hillman, MD 
Associate Professor
Division of Neonatology
Tenure track
Research Interests:
I am interested in ventilator-induced lung injury and the progression of inflammation and injury toward bronchopulmonary dysplasia (BPD) in preterm infants. The focus of my current work is to evaluate the biochemical processes and signaling pathway activated by the initiation of ventilation at birth and developing ways to decrease this injury. I use preterm lamb models to evaluate modes of ventilation and lung injury

Keywords: bronchopulmonary dysplasia, mechanical ventilation, lung injury, inflammation
Ajay Kumar Jain, MD
(Diplomate of American Board of Pediatrics -Sub Board : Pediatric Gastroenterology;
Diplomate of American Board of Pediatrics) Assistant Professor, Tenure Track
Research Interests:
My research interests include pediatric liver diseases. I am part of several multicenter trials relating to pediatric liver diseases. I have special interest in TPN (Total Parenteral Nutrition) associated liver disease and am looking at gene targets and novel molecules that would help in the amelioration of a potentially fatal complication of a lifesaving therapy.

Keywords: TPN, Cholestasis, CDCA, Obesity, NASH
Marta Ania King, MD, MED
Associate Professor
Clinical Educator
Research Interests:
My hospital pediatrics areas of focus are GJ outcomes in neurologically impaired children and inpatient identification and management of obesity. I am currently working on developing scholarly activities in the area of medical education with focus on clinical reasoning.

Keywords: Medical education, clinical reasoning, gastrojejunal feeding, childhood obesity
Joyce Koenig, MD
Professor
Research Interests:
Neonatal inflammation and immunity: Premature neonates are particularly prone to hyper-inflammatory responses that can lead to chronic inflammatory disorders in critical organs, including the brain, eyes, lungs and intestines. Our goal is to understand how neutrophils, alone and in their interactions with other immune cells, direct inflammatory responses in neonates. To achieve this, our studies are focused on in vitro and in vivo studies of human preterm and term neonates and neonatal mice. Neonatal neutrophil function & production: Neonates have increased susceptibility to the development of neutropenia, defined as subnormal numbers of circulating neutrophils. Studies to better understand the mechanisms that regulate neutrophil production and survival in neonates are primarily focused on two conditions commonly associated with neutropenia: preeclampsia (a pregnancy disorder associated with neonatal neutropenia) and neonatal sepsis.

Keywords: Neonate, inflammation, neutrophil, lymphocyte, apoptosis, hematopoiesis
Timothy J Kutz, MD
Associate Professor
Clinical Educator
Research Interests:
Interests include: diagnostic imaging (decreasing radiation, role of fetal Hg), abuse prevention, medical needs of children in foster care/out of home care.

Keywords: abuse, prevention, head injury, foster care
Jennifer S. Ladage, MD
Associate Professor of Pediatrics
Clinical Educator
Research Interests:
It is my goal to develop a clinic to provide comprehensive medical services for refugee children entering St. Louis which will include initial screening as well as long term primary care. The clinic will also provide a longitudinal academic experience for SLU medical students pursuing distinction in global health care or service. In addition, I have an interest in the impact of early trauma on social/emotional development and attachment in children adopted internationally

Keywords: Refugee, Adoption, Health Care Accessibility, child development (disorder, deviation)
Lia Lowrie, MD
Professor
Director, Division of Critical Care Medicine
Clinical educator
Research Interests:
PICU Outcomes, Pediatric Sedation outcomes and processes, Quality

Keywords: Quality, Pediatric sedation, Pediatric intensive care
Adriana Maria Montaño, PhD
Research Associate Professor 
Research Interests: 
Development of Registry and growth charts for patients with MPS IVA; Development of Bone Targeting System for Mucopolysaccharides; Enzyme Replacement Therapy (ERT) pre-clinical trial for patients affected with MPS IVA; Metabolism for Keratan Sulfate; Substrate Reduction Therapy for Mucopolysaccharidoses; Gene Therapy in Morquio A Disease; Studies on chondroitin sulfate metabolism; Characterization of Hyaluronidases; Molecular evolution of glycosaminoglycans; Molecular evolution of peptidoglycan receptor proteins (PGRP) and innate immunity.

Keywords: Mucopolysaccharides, Morquio A disease; chondroitin sulfate metabolism
Susan Myers, MD
Professor of Pediatrics
Research Interests:
My research has mainly been growth hormone studies in subjects of all ages with Prader-Willi syndrome. I have also done some diabetes research, currently a study evaluating our transition process for adolescents.

Keywords: Prader-Willi syndrome, growth hormone therapy, transitioning diabetic adolescents
Albert Nakanishi, MD 
Associate Professor
Research Interests:
a retrospective study on the efficacy and safety of an ED migraine protocol a prospective ED study of IV valproic acid in status migrainous in children a prospective study of hylenex in the treatment of dehydration in very young children (<2 yrs of age)
Blakeslee E. Noyes, MD
Professor of Pediatrics, non-tenure
Research Interests:
Clinical trials in cystic fibrosis, newborn screening for CF, vocal cord dysfunction in adolescents and college athletes

Keywords: Cystic fibrosis, asthma, newborn screening, vocal cord dysfunction
Robert S. Ream, MD
Professor of Pediatrics, Clinical Track (Division of Pediatric Critical Care)
Research Interests:
Current research focuses on describing contemporary practice in pediatric organ donor management across the 58 US organ procurement organizations. This intense period of clinical management typically extends from the declaration of brain death to the recovery of organs in the operating room. The ultimate goal is to determine which aspects of donor management are associated with a greater number of organs donated per donor and improved post transplant organ function. Important liaisons include: Mid-America Transplant Services (MTS), the Organ Donation Research Consortium (ODRC) and the Association of Organ Procurement Organizations (AOPO).

Keywords: organ donor management; organ donor; organ donation; organ procurement; pediatrics
Farouk Sadiq, MD
Associate Professor of Pediatrics (tenure track)
Research Interests:
Melatonin use in hypoxic ischemic encephalopathy

Keywords: Melatonin, newborn, hypoxic ischemic encephalopathy
Heidi M. Sallee MD
Associate Professor, Clinical non-tenure track
Research Interests: Medical Education, parenting, child safety
Anthony J. Scalzo, MD
Professor, non-tenure track
Research Interests:
Interest in studying the use of simulation to train physicians in cognitive and psychomotor pediatric emergency medicine skills. Beginning an ONR funded project to develop and validate a virtual pediatric simulator to train physicians on high-stakes pediatric emergency medicine scenarios.

Keywords: Simulation; Pediatric Emergency Medicine; Virtual Reality; Resuscitation
Elaine C. Siegfried, MD
Professor of Pediatrics and Dermatology (non-tenure track)
Research Interests: Drug development for unmet areas of need in pediatric dermatology, especially severe inflammatory skin disease (atopic dermatitis, psoriasis, overlap) the associated complications of inflammatory skin diseases in children (eczema herpeticum, widespread molluscum, cutaneous Strep, antibiotic-resistant Staph aureus) and pathogenesis (skin barrier defects, altered microbiome and immune dysregulation)

Keywords: dermatitis, HSV, immunodeficiency, microbiome
Kurtis T. Sobush, MD
Assistant Professor of Pediatrics
Tenure-Track
Research Interests: I primarily study distal airway epithelial cell dynamics in both the developing and adult lung during periods of both steady state and injury in mouse models. Specifically, my work focuses on Club (or Clara) cells as the localized progenitor cell population.

Keywords: Airway, Club cells, Progenitor, Epithelium, Lung
Marya Strand, MD, MS
Associate Professor, clinical track
Research Interests:
I am involved in clinical research regarding neonatal resuscitation, particularly in the delivery room setting. I also study educational methodology for teaching/learning neonatal resuscitation skills.

Keywords: Resuscitation, newborn, Neonatal Resuscitation Program, Simulation
Jeffrey Teckman, MD
Professor, with tenure, of Pediatrics and Biochemistry and Molecular Biology. Associate Chair of Pediatrics for Research, Director, Pediatric Gastroenterology and Hepatology Saint Louis University School of Medicine and Cardinal Glennon Children's Medical Center.
Research Interests:
Dr Teckman's research interests involve investigation of the mechanisms of liver injury, especially as related to intracellular proteolysis, with the genetic disease, alpha-1-antittrypsin deficiency as the primary model. Dr Teckman is also involved in a wide range of clinical and translational research projects involving metabolic liver diseases, hepatitis B infection, fatty liver disease, hyperphagia, and cystic fibrosis.

Keywords: alpha-1-antitrypsin, autophagy, liver disease, proteasome, ERAD
Sherida E. Tollefsen, MD
Professor of Pediatrics, Clinical Educator
Research Interests:
I am the PI at SLU, one of 15 sites participating in the NIH-funded, multi-center "Treatment Options for type 2 Diabetes in Adolescents and Youth" (TODAY) Study. In response to the growing epidemic of type 2 diabetes in childhood, the research protocol was designed to evaluate the efficacy of three treatment regimens on time to treatment failure based on glycemic control.

Keywords: TODAY study, type 2 diabetes
Jason Alexander Werner, MD
Assistant Professor (clinical)
Research Interests:
My ongoing investigations relate to Resident and Fellow education, particularly as it relates to issues of patient safety and quality. This includes the utility of high-fidelity patient simulators, teamwork and role identification, and active fostering of a robust safety culture.

Keywords: Simulation, Safety, Fellow Resident, Teamwork
Debra H. Zand, PhD
Associate Professor, tenure track
Dr. Zand's Website

Research Interests:
My research focuses on how individual factors interact with environmental influences in a transactional manner throughout the developmental course of childhood to influence positive adaptation among children and their families. Specifically, I investigate processes that foster resilience in high risk populations of children from birth through emerging adulthood (low income, deaf/hard of hearing, medically fragile), and apply this knowledge to the development and/or adaption of early intervention/prevention programs.

Keywords: Child Development, Developmental Psychopathology, Resilience, Early Intervention/Prevention, Community-Based Participatory Research

 

 

 

 

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