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Current Vaccine Studies

Healthy volunteers of all ages, races, and genders are needed to continue vaccine development at the Saint Louis University Center for Vaccine Development.

Participation in a vaccine study is voluntary and confidential. All study vaccines and tests are free of charge and volunteers receive compensation for time and travel.

Smallpox study (18-45 years old)

Smallpox was an infectious disease caused by a virus called variola. After vaccination campaigns throughout the 19th and 20th centuries the world was considered free of smallpox in 1980.  As mass vaccinations against smallpox halted more than 30 years ago- the US routine vaccinations for smallpox were stopped in 1971- it is estimated that nowadays the majority of the world’s population has no existing protection against smallpox.

 The purpose of this research is to show that three different lots of vaccine produced at different time have the same quality.  In addition, safety data and your immune system’s response will be evaluated after two shots.

 Key Points

  • To participate, you must be 18 to 45 years old
  • You cannot get smallpox from the vaccine
  • Participation is strictly voluntary

 Payment and Time Commitment

  • You will be compensated for participating: $75 per visit and $10 per phone call.
  • Your total participation will be about 39 weeks.
  • There are 6 clinic visits and 1 phone call.

For more information about the study, please contact the Vaccine Center at 314-977-6333 or 1-866-410-6333 (toll-free) and refer to Study IRB #30165

Influenza vaccine study (9-17 year olds)

Influenza continues to be a major threat to human health.  Every year, thousands of persons in the US die from complications of influenza infection.  Effective vaccines have been available for the past 50 years, and are currently recommended to be given annually due to the change in the types of flu that circulate over time. 

The purpose of this research study is to evaluate the safety of an investigational flu M2SR vaccine and your body’s immune response after receipt of the both the investigational and licensed flu vaccine. Vaccination is currently the most effective way of controlling flu and preventing its illness and complications. Vaccines can help prevent illness by causing the body to make antibodies that fight infection. If you are exposed to the flu virus after receiving the flu shot, the antibodies can help to protect you by fighting off the flu virus.  As a result, you may not get sick at all or you may have a much shorter or milder illness. 

Important Points

  • To participate you must be 9-17 years old.
  • The study will last 12 months.
  • There will be 6 clinic visits and 2 phone calls.
  • You will be compensated $75 a visit and $10 a phone call.

Risks and benefits will be discussed prior to enrolling in the study

To discuss volunteering, please contact a nurse at 1-866-410-6333 (toll free) or at and refer to study #326 or IRB # 29081.

Influenza vaccine study (18-45 year olds)

The purpose of the this research is to evaluate the safety, overall side effects, and effectiveness of the 2018-2019 seasonal influenza vaccine, Fluzone or Flublok given with or without one of two adjuvants.  An adjuvant is a substance that may cause the body to produce more antibodies.  Antibodies help your body fight infections.   

Key points: 

  • To participate, you must be 18 to 45 years old.
  • You cannot get influenza from the vaccine.
  • Participation is strictly voluntary

Payment and Time Commitment:

  • You will be compensated for participating: $75 per visit.
  • It is expected that your participation will last about 12 months.
  • There could be up to 10 clinic visits.

To discuss volunteering, please contact a nurse at:

  •  1-866-410-6333 (toll free)
  •  Refer to study #327 or IRB # 30260