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Clinical Trials

Healthy volunteers of all ages, races, and genders are needed to continue vaccine development at the Saint Louis University Center for Vaccine Development.

Participation in a vaccine study is voluntary and confidential. All study vaccines and tests are free of charge and volunteers receive compensation for time and travel.

Flu Challenge Study (18-49 years old)

Background

This is a research study to understand what happens when a person is infected with influenza (“flu”) and how the body controls the infection. To do this, we will infect healthy participants (“challenge”) with a strain of the flu, and follow them to see what symptoms occur and when they occur.

Duration

 It is expected that your participation will last about four months, including screening.

  • An inpatient “challenge” unit stay at the Salus Center will be for at least 10 days, or perhaps longer.
  • After you leave the challenge unit, there will be three more clinic visits and one phone call.

Key Points

  • To participate, you must be 18 to 49 years old and healthy.

Payment and Time Commitment

  • You will be compensated for your time and participation in this study.  You will be paid $75.00 for each required clinic visit (4), $300.00 for each inpatient visit (10), and $10.00 for each phone call (1).  Total is up to $3310.00 for completing all planned study visits

To discuss volunteering, please contact a nurse at:

Influenza vaccine study (9-17 year olds)

Influenza continues to be a major threat to human health.  Every year, thousands of persons in the US die from complications of influenza infection.  Effective vaccines have been available for the past 50 years, and are currently recommended to be given annually due to the change in the types of flu that circulate over time. 

The purpose of this research study is to evaluate the safety of an investigational flu M2SR vaccine and your body’s immune response after receipt of the both the investigational and licensed flu vaccine. Vaccination is currently the most effective way of controlling flu and preventing its illness and complications. Vaccines can help prevent illness by causing the body to make antibodies that fight infection. If you are exposed to the flu virus after receiving the flu shot, the antibodies can help to protect you by fighting off the flu virus.  As a result, you may not get sick at all or you may have a much shorter or milder illness. 

Important Points

  • To participate you must be 9-17 years old.
  • The study will last 12 months.
  • There will be 6 clinic visits and 2 phone calls.
  • You will be compensated $75 a visit and $10 a phone call.

Risks and benefits will be discussed prior to enrolling in the study.

To discuss volunteering, please contact a nurse at 1-866-410-6333 (toll free) or at vaccine@slu.edu and refer to study #326 or IRB # 29081.

A study to test a tuberculosis (TB) medication in subjects with kidney disease and healthy subjects.  (18-70 year olds)

The purpose of this research is to evaluate the safety profile of a drug called Pretomanid in volunteers that have kidney impairments to those who have normal kidney function.  

Key Points 

  • To participate, you must be 18 to 70 years old.

  •  Participation is strictly voluntary.

  •  There is a hospital admission required in this study.

Payment and Time Commitment

  • You will be compensated for participating: $75 per clinic visit. $300 a day for the hospital stay and $10 for the phone call. Total is up to $1585.00 for completing all planned study visits and hospital stay.

  •  There are 5 clinic visits, 3-4 day hospital stay and one phone call.

To discuss volunteering, please contact a nurse at:

  •  1-866-410-6333 (toll free)
  •  vaccine@slu.edu 
  •  Refer to study  IRB # 30150