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Clinical Trials

Healthy volunteers of all ages, races, and genders are needed to continue vaccine development at the Saint Louis University Center for Vaccine Development.

Participation in a vaccine study is voluntary and confidential. All study vaccines and tests are free of charge and volunteers receive compensation for time and travel. Participation involves completing a short online survey that includes some personal questions. Your participation is voluntary.

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COVID-19 Vaccine trial, Gritstone (18 years and older)

Background

 The purpose of this study is to test four investigational vaccines for the coronavirus that emerged in Wuhan, China in December 2019 that can cause serious respiratory infections. The virus is named SARS-CoV-2 due to its similarity to the Severe Acute Respiratory Syndrome [SARS] Coronavirus [CoV]. The disease caused by SARS-CoV-2 is called Coronavirus disease 2019 (COVID-19). This study will assess the safety and tolerability of different doses of four investigational SARS-CoV-2 vaccines when administered as prime (first vaccination) and/or boost (second vaccination) in healthy adult volunteers. The vaccine(s) you receive will depend on the Stage and Group in which you are enrolled. You will not get to choose which vaccine(s) you receive; this will be determined by the timing of your enrollment and your age.

Duration

  • All subjects will take part in between 12-13 study clinic visits that include the initial screening visit, two study vaccination visits, and 9-10 follow-up clinic visits and 4 phone calls.

Key Points

  • To participate, you must be 18 years old and older.
  • Cannot have had COVID-19.  
  • Cannot have had a vaccination for COVID-19.

Payment and Time Commitment

  • You will be compensated for your time and participation in this study.  You will be paid $75 for clinic visits and $10 a phone call. 

To discuss volunteering, please contact a nurse at:

  • 1-866-410-6333 (toll free)
  • 314-977-6333
  • vaccine@slu.edu 
  • Refer to study IRB #17622

Division of Allergy, Immunology, and Transplantation (DAIT) National Institute of Allergy and Infectious Diseases (NIAID) / “Systemic Allergic Reactions to SARS-CoV-2 Vaccination

This research is being done to determine whether highly allergic people or people with mast cell disorders (a buildup of the white blood cells that release substances causing symptoms similar to an allergic reaction) are more likely to have an allergic reaction to the new Pfizer- BioNTech and Moderna COVID-19 vaccines than other people. We would also like to understand why some people have allergic reactions to these vaccines.

Key Points

  • We are looking for people who are between 18-69 years old with severe allergic reactions.
  • You will be compensated for your time and participation in this study.
  • You cannot participate if you have been vaccinated against COVID-19.

To discuss volunteering, please contact a nurse at:

  • 1-866-410-6333 (toll free)
  • 314-977-6333
  • vaccine@slu.edu  
  • Refer to study IRB #17624

Leukapheresis study for those who have tested positive to COVID-19 (18-65 years old) (Currently on hold)

Background

The purpose of this research is to study some specific blood cells (called dendritic cells) that will be removed from your blood.  Your cells will be used in the research laboratory in studies of other blood cells collected from people who have tested positive for COVID 19. Dendritic cells are the best “stimulator” cells for this work. These specific blood cells (dendritic cells) will be removed from your white blood cells in the laboratory. The process to remove your white blood cells is called Leukapheresis procedure. This procedure will require that you remain in the blood collections department for approximately four-six hours.

If you tested positive for COVID-19, you will be asked to participate approximately one-two months after you have recovered from your COVID-19 illness.

Key Points

  • To participate, you must be between 18-65 years old.
  • You will be asked to participate approximately one-two months after you have recovered from your COVID-19 illness.

Payment and Time Commitment

You will be compensated for your time and participation in this study.  You will be paid $75 for the screening visit and $200 for the leukapheresis procedure.

To discuss volunteering, please contact a nurse at:

  • 1-866-410-6333 (toll free)
  • 314-977-6333
  • vaccine@slu.edu  
  • Refer to study IRB #27790

A study to test a tuberculosis (TB) medication in subjects with kidney disease and healthy subjects.  (18-70 years old) (Currently on hold)

The purpose of this research is to evaluate the safety profile of a drug called Pretomanid in volunteers that have kidney impairments to those who have normal kidney function.  

Key Points 

  • To participate, you must be 18 to 70 years old.

  •  Participation is strictly voluntary.

  •  There is a hospital admission required in this study.

Payment and Time Commitment

  • You will be compensated for participating:

    • $75 per clinic visit. $300 a day for the hospital stay and $10 for the phone call.

    • Total is up to $1,585 for completing all planned study visits and hospital stay.

  •  There are five clinic visits, a three-four day hospital stay and one phone call.

To discuss volunteering, please contact a nurse at:

  •  1-866-410-6333 (toll free)
  •  vaccine@slu.edu 
  •  Refer to study  IRB # 30150