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Division of Pediatric Gastroenterology and Hepatology

The Saint Louis University Division of Pediatric Gastroenterology and Hepatology provides patient care, has active research programs in several diverse areas and participates regularly in medical education at the medical student and resident levels. 


The division sees many patients with diverse types of problems ⁠— from generally healthy children burdened with common problems such as GERD, chronic abdominal pain or constipation that can significantly disrupt their development, family life, and ability to function well at school, to chronic, life-threatening diseases that require complex diagnostic workups and long-term management. 

We have distinct multidisciplinary clinics that care for our more complex patients, including the Inflammatory Bowel Disease center that follows over 250 patients with Crohn's disease and ulcerative colitis and the chronic liver disease and transplant clinic.

The Gastrointestinal Motility Center is one of only a handful of centers in the country that provides the full spectrum of diagnostic testing for patients with GI motility disorders. The intestinal rehabilitation program treats infants and children with short bowel syndrome or other causes of intestinal failure, many of whom require home administration of long-term total parenteral nutrition. The intestinal rehabilitation staff of the GI Division reviews all inpatients at SSM Health Cardinal Glennon Children's Hospital who are on parenteral nutrition weekly.

Our division works closely with a dedicated team of pediatric specialists and allied health professionals, including pediatric psychologists, nurses, dietitians, speech pathologists, social workers, physical and occupational therapists both on the inpatient rounds and with links to our outpatient clinics. These are key ancillary personnel who enhance our quality of patient care.

Our service has continued to grow. We have reached a 44% market share for pediatric gastroenterology in the St. Louis region, which is more significant than any other area provider, increasing our quality and patient satisfaction. We look forward to continued growth and quality improvement.

Clinical Programs

Guided Imagery Pain Control Program

Kathy Spranaitis, R.N., P.N.P., has specialized training in guided imagery pain reduction. This method of CBT pain control, similar to techniques used in natural child birth pain control, are proven effective at reducing pain related to GI inflammation, IBS, and many other causes.

Healthy First Weight Management Program

This is our program for weight management, obesity and bariatric surgery through which Saint Louis University and SSM Health Cardinal Glennon Hospital have been serving our community for more than 20 years. This program is based on proven science and combines medical care, nutrition, psychology, exercise, family support and surgery, when needed, to improve the health of children who are concerned about excessive weight gain. The program is a partnership between general pediatrics, pediatric gastroenterology, psychology and surgery in which multiple providers bring the most recent therapies to our patients.

View SSM Health Bariatric Surgery


Total Parental Nutrition

Ajay Jain, M.D., has published several basic science research papers on ameliorative strategies for Total Parenteral Nutrition (TPN) associated liver and gut injury. He has established a novel ambulatory TPN animal model system and has received several highly competitive extramural and intramural research grants as a principal investigator. His focus has been to evaluate the Gut-Liver crosstalk in the context of TPN as regulated by the enterohepatic circulation of bile acids and the gut microbiota. Dr. Jain recently received a very large National Institute of Health (NIH) grant to further clarify the mechanistic links leading to TPN associated injury. He serves as a moderator at several national meetings and has done multiple national and international plenary platform presentation relating to his work.

He serves as a grant and manuscript reviewer for several national consortia and journals and as the PI for a national NIH funded conference grant evaluating the role of gut derived signals in maintaining normal health and nutrition. He has also received funding for research involving gut adaptation post short bowel surgery and ameliorative strategies for the associated liver injury in this model. He chairs the hospital's nutrition advisory committee.

Dr. Jain also has extramural support on studies involving the orphan liver disease, Lysosomal Acid Lipase Deficiency and is a collaborator on an NIH funded multinational study evaluating technology platforms for improving international immunization practices. He is also collaborating on research involving noninvasive biomarkers for liver disease. He is the medical director for pediatric liver transplantation and our site principal investigator for Studies in Pediatric Liver Transplantation (SPLIT consortium). Dr. Jain is also part of a multi-center NIH funded research study for evaluation of fatty liver disease and serves as our site pediatric investigator (one of eight centers nationally).

Ajay Jain, M.D., DNB, Rearch Support:
Active Research
1. NIH-1 R03 DK121046-01. Role of gut microbiota in total parenteral nutrition associated injury. 04/01/2019 – current. Role: Principal Investigator: Ajay Jain. $227,250
2. NIH-1U01-DK61718, NIH NASH CRN Neuschwander-Tetri, PI 07/01/2011 – current Multicenter studies on the etiology, contributing factors, natural history, and treatment of nonalcoholic steatohepatitis (NASH) Site, Role: Saint Louis University, Co-Investigator. $10,479.
3. NIH - R13DK124950-01. Novel Nutritional Status Biomarkers. 03/01/2020 – 02/28/2021. Role: Principal Investigator: Ajay Jain. $12,500
4. Zealand Pharmaceuticals: Role of novel gut growth promoters in intestinal rehabilitation: April 2018-Aug 2019. Role: Principal Investigator: Ajay Jain. $87,000
5.  Clinical Innovation Fund: Cytokeratin 18 as a biomarker for rejection in liver transplantation. Mid America Transplant Foundation. 07/01/2018-06/30/2020 Role: Principal Investigator: Ajay Jain. $161,173
6.  NIH-NIDDK, NIEHS: CHEAR: The Children’s Health Exposure Analysis Resource (CHEAR) to develop a proposal for the study, 'Role of environmental toxicants in modulating disease severity in children with NAFLD'. 2018 – current. Role: Principal Investigator: Ajay Jain. $9,000. NIEHS – Sample analysis costs (approx. $500,000)
7. NIH NIDDK (NCT NCT03467217): STOP-NAFLD trial, Losartan for the Treatment of Pediatric NAFLD: A Phase 2, Randomized, Placebo-Controlled Clinical Trial. Principal Investigator: Role: Site Principal Investigator: Ajay Jain
8. Presidents Research Fund. Role of Testosterone in Young Males with Non-Alcoholic Steatohepatitis. 07/01/2019-06/30/2020 Role: Principal Investigator: Ajay Jain. $50,000
9. Bill and Melinda Gates Foundation, Jain SK, PI, 11/01/2017 – 11/01/2019 Grand Challenges Explorations, "Improving Childhood Immunizations with Cellular Technology" Site, Role: Saint Louis University, Co-Investigator. $100,000
10. NIH K08DK098623-01A1: Role of the bile acid activated receptors FXR and TGR5 in Total Parenteral Nutrition associated hepatic and gut disease: 02/01/2016 Role: Principal Investigator: Ajay Jain. $703,620
11. DeNardo (Health Sciences) Education and Research Foundation: Heuertz R, PI, 2017-2019Active Learning Through Research. Site, Role: Saint Louis University, Co-Investigator. $24,000.
12.  Fleur-de-lis: Role of fecal transplantation in parenteral nutrition associated injury. 07/01/2018 – 10/30/2019. Role: Principal Investigator: Ajay Jain. $25,000
13.  Fleur-de-lis: Profiling the gut microbiome in individuals with Prader-Willi Syndrome, PI Whitman B 07/01/2017 – 10/30/2019 Role: Co- Investigator: Ajay Jain. $25,000
14.  SPLIT: Studies of Pediatric Liver Transplantation: SPLIT works to identify emerging trends in care, focusing on short- and long-term outcomes with a goal of gaining new knowledge that can be translated into changes in clinical practice. This research also generates new ideas for translational research/clinical trials which SPLIT actively pursues. 05/2013-Current Role: Principal Investigator: Ajay Jain.

Completed Research
1. NIH-1R03EB015955-01, Jain SK, PI, 09/30/2015 – 07/31/2017. Enhancing Health Care Access with Cellular Technology. Site, Role: Saint Louis University, Co-Investigator. $13,318.
2. NIH R13DK109671-01: Gastric Bypass: Role of the Gut. 2017: March 2018 Title: A.S.P.E.N. 2017 Research Workshop. Role: Principal Investigator: Ajay Jain. $10,000 
3. NASPGHAN Young Investigator Award/Nestle Nutrition Award: (North American Society for Pediatric Gastroenterology, Hepatology and Nutrition): Nov 2014-Nov 2016 ‘Role of Bile Acids in Preventing Parenteral Nutrition Associated Disorders’ Site, Role: Principal Investigator: Ajay Jain. $150,000.
4.  A.S.P.E.N. Rhoads Research Foundation: (American Society for Parenteral and Enteral Nutrition): 01/01/2014-12/31/2015 ‘Novel Interventions Modulating the FXR-FGF19 Axis and the TGR5-GLP Axis as Therapeutic Approaches for TPN Associated Pathologies’ Site, Role: Principal Investigator: Ajay Jain. $50,000
5.     Fleur-de-lis: Role of FXR-FGF19 and TGR5-GLP2 axis in parenteral nutrition associated pediatric liver and gut injury. 07/01/2017 – 06/30/2018 Role: Principal Investigator: Ajay Jain. $25,000
6. Synageva (Lexington, MA): Industry Supported: 2014-2018 ‘Determination of Lysosomal Acid Lipase Activity and Cholesterol Ester Storage Disease Prevalence’ Site, Role: Principal Investigator: Ajay Jain. $25,000.
7. Thrasher Fund: Shear wave sonoelastography for the noninvasive evaluation of hepatic fibrosis in the pediatric population. May 2015. Role: Collaborator.
8. NIH/NIDDK, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases - Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC) Childhood Liver Disease Research and Education network (ChiLDREN). Jun 2011 Role: Site Sub-Investigator.
9. SLU Liver Center Grant: 03/01/2015-06/30/2017 ‘Role of Glucagon Like Peptides (GLPs) in Total Parenteral Nutrition’ Site, Role: Principal Investigator: Ajay Jain. $25,000.
10. Fleur-de-lis:Role of enteral bile acids as gut growth promoters in an animal model of short bowel syndrome. 07/01/2016 – 06/30/2017 Role: Co- Principal Investigator: Ajay Jain. $25,000
11. Fleur-de-lis Grant Award: 07/1/2014-06/30/2015 ‘Role of Glucagon-Like Peptides and Oleanolic Acid in Total Parenteral Nutrition (TPN) associated gut and hepatic dysfunction’ Site, Role: Principal Investigator: Ajay Jain. $25,000
12. Presidents Research Fund: 03/01/2014-02/28/2015 ‘New Strategies for Parenteral Nutrition Associated Liver and Gut Disease’ Site, Role: Principal Investigator: Ajay Jain. $47,000
13. Departmental Funds from Chairman – Jain PI 07/01/12 – 03/30/2014 ‘A newer modality of total parenteral nutrition infusion in piglets’ Site, Role: Principal Investigator: Ajay Jain. $20,000
14. American Liver Foundation Jain, PI 2008-2009 ‘Role of Farnesoid X Receptor (FXR) and Fibroblast Growth Factor 19 (FGF19) In Parenteral Nutrition Associated Liver Disease (PNALD)’ Site, Role: Principal Investigator: Ajay Jain. $12,500
15. Indian Council of Medical Research Jain, PI 2001-2004 ‘Seroefficacy of Hepatitis B Vaccine Administered in The Expanded Programme of Immunization at 0, 6 wks and 9 months’ Site, Role: Maulana Azad Medical College, Delhi. Principal Investigator: Ajay Jain. $10,000

Liver Injury

Jeffrey Teckman, M.D., has an ongoing, funded basic science research program in liver injury using the genetic disease, alpha-1-antitrypsin deficiency as the primary model system. He is a recognized international authority in this condition. Dr. Teckman has had 24 years of continuous extramural research funding in this area from a combination of NIH, private and industry sources, and has been involved in basic science studies as well as human drug trials.

Dr. Teckman is also the Principal Investigator for our site of an NIH funded, multi-center study (one of 14 centers nationally) in pediatric metabolic liver disease, known as the Childhood Liver Disease Research Network. Dr. Teckman is also the Pediatric Center Private Investigator (PI), with Dr. Adrian DiBisceglie as the SLU center PI, for the NIH sponsored, multi-center study of hepatitis B infection. SSM Health Cardinal Glennon is one of seven pediatric centers nationally for this study.

Dr. Teckman participated in an industry sponsored drug trial in hepatitis C this last two years and is the National PI for a privately funded multi-center study of adult liver disease. A new grant has just been funded to expand support for these efforts. Dr. Teckman collaborates with many other investigators, which routinely results in further publications, which at present include biochemical studies of liver injury, mentoring junior investigators in studies of liver imaging liver, gene therapy projects and analysis of the hyperphagia of Prader-Willi Syndrome. Dr. Teckman also has many industry partners and is involved in drug development and drug research grants, which have led to additional publications.

Clinical Trials

We offer clinical trials of new drugs and research in several areas including: Liver disease, fatty liver, alpha-1-antitrypsin, hepatitis B, hepatitis C, Crohns Disease/IBD, Cystic Fibrosis GI disease, GI motility and gastroparesis, and liver transplant. Contact our office at 314-577-5647 for information and to consider participation.


Sara Henen, M.D.
  • Henen S, Denton C, Teckman J, Borowitz D, Patel D. Review of Gastrointestinal Motility in Cystic Fibrosis. J Cyst Fibros. 2021 Jun 16:S1569-1993(21)00173-9. doi: 10.1016/j.jcf.2021.05.016. Epub ahead of print. PMID: 34147362.
Ajay Jain, M.D.
  • Madnawat, H., Welu, A. L., Gilbert, E. J., Taylor, D. B., Jain, S., Manithody, C., … Jain, A. K. (2020). Mechanisms of Parenteral Nutrition-Associated Liver and Gut Injury. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 35(1), 63–71. 
  • Price A, Blomenkamp K, Manithody C, et al. Developing a Novel Ambulatory Total Parenteral Nutrition-Dependent Short Bowel Syndrome Animal Model. Journal of Surgical Research. 2019;234:13-19. doi:10.1016/j.jss.2018.08.042.
  • Jain A. Pediatric Fatty Liver Disease. Missouri medicine. 2019;(2):123.
  • Shapiro WL, Yu EL, Arin JC, et al. Clinical Practice Approach to Nonalcoholic Fatty Liver Disease by Pediatric Gastroenterologists in the United States. Journal of Pediatric Gastroenterology & Nutrition. 2019;68(2):182-189. doi:10.1097/MPG.0000000000002194.
  • Christine Denton, Amber Price, Julie Friend, et al. Role of the Gut–Liver Axis in Driving Parenteral Nutrition-Associated Injury. Children. 2018;(10):136. doi:10.3390/children5100136.
  • Compher C, Jain AK, Nichol PF, et al. Research Agenda 2018: The American Society for Parenteral and Enteral Nutrition. JPEN Journal of Parenteral & Enteral Nutrition. 2018;42(5):838-844. doi:10.1002/jpen.1312.
  • Villalona G, Price A, Blomenkamp K, et al. No Gut No Gain! Enteral Bile Acid Treatment Preserves Gut Growth but Not Parenteral Nutrition–Associated Liver Injury in a Novel Extensive Short Bowel Animal Model. JPEN, Journal of parenteral and enteral nutrition. 2018;(8):1238.
  • Harlow KE, Africa JA, Wells A, et al. Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease. The Journal Of Pediatrics. 2018;198:76-83.e2. doi:10.1016/j.jpeds.2018.02.038.
  • Seth R, Akinboyo I, Chhabra A, Qaiyum Y, Shet A, Gupte N, Jain AK, Jain SK. Mobile-Phone Incentives for Childhood Immunizations in Rural India. Pediatrics. 2018 Apr;141(4). pii: e20173455. doi: 10.1542/peds.2017-3455. Epub 2018 Mar 14
  • Jain AK, Roux CW, Puri P, et al. Proceedings of the 2017 ASPEN Research Workshop—Gastric Bypass: Role of the Gut. JPEN, Journal of parenteral and enteral nutrition. 2018;(2):279.
  • Puri P, Price A, Gillevet Patrick, Blomenkamp K, Sikaroodi M, Heafner N, Westrich M, Pochampally S, Kakarla V, Greenspon J, Villalona G, Guzman M, Long J, Tetri B, Teckman, JH, Jain AK. Firmicutes dominance is associated with lower serum bilirubin level in a novel ambulatory model of parenteral nutrition induced liver injury and gut atrophy. (NASPGHAN 2017)
  • Shapiro WL, Africa J, Jain AK, Schwimmer J et al. Approach to the Management of Pediatric NAFLD by Pediatric Gastroenterologists and Hepatologists across the United States. (NASPGHAN 2017)
  • Schwimmer JB, Wilson LA, Fishbein MH, Jain AK, Karpen SJ, Molleston JP, Murray KF, Newton KP, Rosenthal P, Vos MB, Xanthakos SA, Hoofnagle JH, Behling C, Clark JM, Lavine JE. Improvements in serum aminotransferase levels are associated with improvements in liver histology in children with nonalcoholic fatty liver disease (NAFLD). (AASLD 2017)
  • Xanthakos SA, Lavine JE, Yates K, Schwimmer JB, Molleston JP, Rosenthal P, Murray KF, Vos MB, Jain AK, Fishbein M, Behling C, Brunt EM, Tonascia J and Doo E. Natural history of nonalcoholic fatty liver disease (NAFLD) in children receiving standard lifestyle counseling and placebo in NASH Clinical Research Network (CRN) trials. (AASLD 2017)
  • Schwimmer JB, Lavine JE, Wilson LA, Neuschwander-Tetri BA, Xanthakos SA, Kohli R, Barlow SE, Vos MB, Karpen SJ, Molleston JP, Whitington PF, Rosenthal P, Jain AK, Murray KF, Brunt EM, Kleiner DE, Van Natta ML, Clark JM, Tonascia J, Doo E. In Children with Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but does not Reduce Disease Activity Scores. Gastroenterology. 2016 Aug 25. pii: S0016-5085(16)34969-1
  • Jain AK, Sharma A, Arora S, Blomenkamp KS, Jun I, Luong R, Westrich, DJ, Mittal A, Buchanan PM, Guzman MA, Long JP, Neuschwander-Tetri BA, Teckman JH. Preserved gut microbial diversity accompanies upregulation of TGR5 and hepatobiliary transporters in bile acid treated animals on Parenteral Nutrition. JPEN J Parenter Enteral Nutr. 2016 Aug 8. Premier Research Paper
  • Jain AK, McOmber M, Gilger M. Foreign bodies of the esophagus in children. up-to-date, Sep 2, 2016
  • Jain AK, Teckman JH. Wilson Disease: Hepatic Manifestations. Clinical Decision Support, Feb 2016
  • Wooton-Kee CR, Jain AK, Michael A, Grusak MA, Finegold MJ, Lutsenko S, Moore DD. Elevated copper impairs hepatic nuclear receptor function in Wilson's disease. J Clin Invest. 2015 Sep;125 (9):3449-60.
  • Mavers M, Blaufuss T, Friedman H, Becker BA, Jain AK. Eosinophilic esophagitis in a pediatric patient with Herpes simplex virus esophagitis. A cause or a consequence?. OJCMR, Vol 1, Issue 6: Oct 2015
  • Jain AK, Teckman JH. Controversies in the mechanism of Total Parenteral Nutrition induced pathology. Children, Jul 2015, 2, 358-370.
  • Jain AK, Wen JX, Blomenkamp KS, Arora S, Blaufuss TA, Rodrigues J, Long JP, Neuschwander-Tetri BA, Teckman, JH. Oleanolic Acid improves gut atrophy induced by Total Parenteral Nutrition (TPN). JPEN J Parenter Enteral Nutr. 2015 Apr 28: 2015 Premier Research Paper
Nisha Mangalat, M.D.
  • Mangalat N, Teckman J. Pediatric Intestinal Failure Review. Children (Basel). 2018 Jul 20;5(7):100. doi: 10.3390/children5070100. PMID: 30037012; PMCID: PMC6069045.
  • Mangalat N. Pediatric Intestinal Failure: A Review of the Scope of Disease and a Regional Model of a Multidisciplinary Care Team. Mo Med. 2019 Mar-Apr;116(2):129-133. PMID: 31040499; PMCID: PMC6461325.
  • Teckman JH, Mangalat N. Alpha-1 antitrypsin and liver disease: mechanisms of injury and novel interventions. Expert Rev Gastroenterol Hepatol. 2015 Feb;9(2):261-8. doi: 10.1586/17474124.2014.943187. Epub 2014 Jul 28. PMID: 25066184.
  • Larson-Nath C, Goday PS, Fiechtner L, Mangalat N, Schwartz S, Scheimann A, Sentongo T, Turner JM; NASPGHAN Committee on Nutrition. NASPGHAN Nutrition University (N2U): A Survey of its Efficacy as Continuing Nutrition Education for North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2020 Aug;71(2):e68-e71. doi: 10.1097/MPG.0000000000002760. PMID: 32732789.
  • Liu Y, Fatheree NY, Mangalat N, Rhoads JM. Human-derived probiotic Lactobacillus reuteri strains differentially reduce intestinal inflammation. Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1087-96. doi: 10.1152/ajpgi.00124.2010. Epub 2010 Aug 26. PMID: 20798357; PMCID: PMC2993169.
  • Mangalat N, Tatevian N, Bhattacharjee M, Rhoads JM. Alpers syndrome: an unusual etiology of failure to thrive. Ultrastruct Pathol. 2012 Aug;36(4):219-21. doi: 10.3109/01913123.2012.666334. PMID: 22849523.
  • Mangalat N, Bell C, Graves A, Imseis EM. Natural history of conjugated bilirubin trajectory in neonates following parenteral nutrition cessation. BMC Pediatr. 2014 Dec 10;14:298. doi: 10.1186/s12887-014-0298-z. PMID: 25492029; PMCID: PMC4275980.
  • Mangalat N, Liu Y, Fatheree NY, Ferris MJ, Van Arsdall MR, Chen Z, Rahbar MH, Gleason WA, Norori J, Tran DQ, Rhoads JM. Safety and tolerability of Lactobacillus reuteri DSM 17938 and effects on biomarkers in healthy adults: results from a randomized masked trial. PLoS One. 2012;7(9):e43910. doi: 10.1371/journal.pone.0043910. Epub 2012 Sep 6. PMID: 22970150; PMCID: PMC3435331.
  • Liu Y, Fatheree NY, Mangalat N, Rhoads JM. Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-κB signaling in the intestine. Am J Physiol Gastrointest Liver Physiol. 2012 Mar 15;302(6):G608-17. doi: 10.1152/ajpgi.00266.2011. Epub 2011 Dec 29. PMID: 22207578; PMCID: PMC3311308.
Fernando Medina Carbonell, M.D.
  • Medina Carbonell FR, Choyudhry Chandan O. Body Mass Index at Presentation of Inflammatory Bowel Disease in Children. Pediatr Gastroenterol Hepatol Nutr. 2020 Sep;23(5):439-446. doi: 10.5223/pghn.2020.23.5.439. Epub 2020 Aug 27. PMID: 32953639; PMCID: PMC7481061.
Dhiren Patel, M.D.
  • Patel D, McAllister SL, Teckman JH. Alpha-1-antitrypsin Deficiency Liver Disease; in Recent Advances in Rare Liver Diseases, Translational Gastroenterology and
    Hepatology (in press).
  • Patel D, Teckman JH. Liver disease with unknown etiology – have you ruled out
    alpha-1 antitrypsin deficiency? Chapter 3. CSL Behring Sponsored Monograph on
    Alpha-1-antitrypsin. (in press).
  • Kim SJ, Ratchford TL, Buchanan PM, Patel DR, Tao TY, Teckman JH, Brown JJ, Farmakis SG. "Diagnostic accuracy of non-contrast magnetic resonance enterography in detecting active bowel inflammation in pediatric patients with diagnosed or suspected inflammatory bowel disease to determine necessity of gadolinium-based contrast agents." Pediatric Radiology 2019;49(6):759-769. doi:10.1007/s00247-019-04369-6. 
  • Stevens J, Wyatt C, Brown P, Patel D, Grujic D, Freedman SD. Absorption and Safety With Sustained Use of RELiZORB Evaluation (ASSURE) Study in Patients With Cystic Fibrosis Receiving Enteral Feeding. Journal of Pediatric Gastroenterology and Nutrition. 2018;(4):527. doi:10.1097/MPG.0000000000002110.
  • Ratchford TL, Teckman JH, Patel DR. Gastrointestinal pathophysiology and nutrition in cystic fibrosis. Expert Review Of Gastroenterology & Hepatology. 2018;12(9):853-862. doi:10.1080/17474124.2018.1502663.
  • Patel D, Teckman JH. Alpha-1-Antitrypsin Deficiency Liver Disease. Clinics in Liver Disease. 2018;22(4):643-655. doi:10.1016/j.cld.2018.06.010.
  • Ratchford TL, Kirby AJ, Pinz H, Patel DR. Congenital Diarrhea from DGATI Mutation Leading to Electrolyte Derangements, Protein-Losing Enteropathy, and Rickets. Journal of Pediatric Gastroenterology and Nutrition, DOI: 10.1097/MPG.0000000000001750.
Jeffrey Teckman, M.D.
  • Stearns K, Goldklang M, Xiao R, et al.
    Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury. PloS one. 2021;16(2):e0246040.
  • Kamath BM, Wen Y, Goodrich NP, Loomes KM, Romero R, Heubi JE, Leung DH,
    Spinner NB, Piccoli DA, Alonso EM, Guthery SL, Karpen SJ, Mack CL, Molleston JP,
    Murray KF, Rosenthal P, Squires JE, Teckman JH, Wang KS, Thompson RJ, Magee JC, Sokol RJ, the Childhood Liver Disease Research Network. Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multi-Centre Observational Study. Hepatol Commun. 2020. 4(3):387-398. PMCID PMC7049675
  • Wooddell CI, Blomenkamp K, Peterson RM, Subbotin VM, Schwabe C, Hamilton J,
    Chu Q, Christianson DR, Hegge JO, Kolbe J, Hamilton HL, Branca-Afrazi MF, Given BD, Lewis DL, Gane E, Kanner SB, Teckman JH. Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease. JCI Insight 2020 Jun 18;5(12):135348. doi: 10.1172/jci.insight.135348. PMID: 32379724
  • Teckman J, Rosenthal P, Hawthorne K, Spino C, Bass LM, Murray KF, Kerkar N,
    Magee JC, Karpen SJ, Heubi JE, Molleston JP, Squires RH, Kamath BM, Guthery SL,
    Loomes KM, Sherker AH, Sokol RJ. Longitudinal Outcomes in Young Patients with
    Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension. J Pediatr 2020 (in press).
  • Shneider BL, Goodrich NP, Ye W, Sawyers C, Molleston JP, Merion RM, Leung DH,
    Karpen SJ, Kamath BM, Cavallo L, Kasper KS, Teckman JH, Squires JE, Sundaram SS, Rosenthal P, Romero R, Murray KF, Loomes KM, Jensen MK, Bezerra JA, Bass LM, Sokol RJ, Magee JC, the Childhood Liver Disease Research Network. Nonfasted Liver Stiffness Correlates with Liver Disease Parameters and Portal Hypertension in
    Pediatric Cholestatic Liver Disease. Hepatol Commun. 2020 (In Press).
  • Kaserman JE, Hurley K, Dodge M, Villacorta-Martin C, Vedaie M, Jean JC, Liberti DC, James MF, Higgins MI, Lee NJ, Washko GR, San Jose Estepar R, Teckman J, Kotton DN, Wilson AA. A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells. Stem Cell Reports. 2020 Jun 23:S2213- 6711(20)30227-7. doi: 10.1016/j.stemcr.2020.06.006. Online ahead of print. PMID: 32619491
  • Rodriguez-Baez N, Murray KF, Kleiner DE, Ling SC, Rosenthal P, Carlin K, Cooper K, Schwarz KB, Schwarzenberg SJ, Teckman JH, Ghany MG, Alawad AS. Hepatic
    Histology in Treatment-naïve Children With Chronic Hepatitis B Infection Living in the United States and Canada. J Pediatr Gastroenterol Nutr. 2020 Jul;71(1):99-105. doi: 10.1097/MPG.0000000000002712. PMID: 32265408
  • Attanasio S, Ferriero R, Gernoux G, De Cegli R, Carissimo A, Nusco E, Campione
    S, Teckman J, Mueller C, Piccolo P, Brunetti-Pierri N. CHOP and c-JUN upregulate the mutant Z alpha-1 antitrypsin, exacerbating its aggregation and liver proteotoxicity. J Biol Chem. 2020 Jul 28:jbc.RA120.014307. doi: 10.1074/jbc.RA120.014307 PMID: 32723872
  • Patel D, McAllister SL, Teckman JH. Alpha-1-antitrypsin Deficiency Liver Disease; in Recent Advances in Rare Liver Diseases, Translational Gastroenterology and
    Hepatology (in press).
  • Patel D, Teckman JH. Liver disease with unknown etiology – have you ruled out
    alpha-1 antitrypsin deficiency? Chapter 3. CSL Behring Sponsored Monograph on
    Alpha-1-antitrypsin. (in press).
  • Brantly M, Campos M, Davis AM, D'Armiento J, Goodman K, Hanna K, O'Day M,
    Queenan J, Sandhaus R, Stoller J, Strange C, Teckman J, Wanner A. Detection of
    alpha-1 antitrypsin deficiency: the past, present and future. Orphanet J Rare Dis.
    2020 Apr 19;15(1):96. doi: 10.1186/s13023-020-01352-5.
  • Wang C, Zhao P, Sun S, Teckman J, Balch WE. Leveraging Population Genomics for Individualized Correction of the Hallmarks of Alpha-1 Antitrypsin Deficiency. Chronic Obstr Pulm Dis. 2020 Jul;7(3):224-246. doi: 0.15326/jcopdf.7.3.2019.0167. PMID: 32726074
  • Kim SJ, Ratchford TL, Buchanan PM, Patel DR, Tao TY, Teckman JH, Brown JJ, Farmakis SG. "Diagnostic accuracy of non-contrast magnetic resonance enterography in detecting active bowel inflammation in pediatric patients with diagnosed or suspected inflammatory bowel disease to determine necessity of gadolinium-based contrast agents." Pediatric Radiology 2019;49(6):759-769. doi:10.1007/s00247-019-04369-6.
  • Di Bisceglie, AM, King, WC, Lisker-Melman, M, Khalili, M, Belle, SH, Feld, JJ, Ghany, MG, Janssen, HLA, Lau, D, Lee, WM, Ling, SC, Cooper, S, Rosenthal, P, Schwarz, KB, Sterling, RK, Teckman, JH, Terrault, N, Chung, RT, Roberts, LR, Hassan, MA, Sarah Jane Schwarzenberg, MA, Wong, DK, Juan, J, Yim, C, Patel, K, Murakami, CS, Perrillo, R, Rodriguez-Baez, N, Han, S-HB, Geffen, D, Tran, TT, Anna Suk-Fong Lok, TT, Fontana, RJ, Younoszai, B, Fried, MW, Muir, A, Evon, D, Darling, JM, Carithers, RC, Shuhart, M, Kowdley, KV, Wang, CC, Murray, KF, Luketic, VA, Jake Liang, T, Hoofnagle, JH, Doo, E, Chang, K-M, Park, J-J, Wahed, A, Cloonan, Y & Kleiner, D. Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B. Journal of Viral Hepatitis. 2019;(7):856. doi:10.1111/jvh.13104.
  • Rosenthal, P, Ling, SC, Belle, SH, Murray, KF, Rodriguez, BN, Schwarzenberg, SJ, Teckman, J, Lin, HS & Schwarz, KB 2019, ‘Combination of Entecavir/Peginterferon Alfa‐2a in Children With Hepatitis B e Antigen–Positive Immune Tolerant Chronic Hepatitis B Virus Infection’, Hepatology, no. 6, p. 2326
  • Schwarzenberg SJ, Ling SC, Cloonan YK, Lin HS, Evon DM, Murray KF, Rodriguez-Baez N, Rosenthal P, Teckman J, Schwarz KB. Health-related Quality of Life in Pediatric Patients with Chronic Hepatitis B Living in the United States and Canada. J Pediatr Gastroenterol Nutr. 2017 May;64(5):760-769. PMID: 28169971
  • Mukhopadhyay A, Baligar P, Mohanty S, Arindkar S, Mukherjee S, Teckman JH, Patel S. Bone marrow stem cell therapy partially ameliorates pathological consequences of liver in mice expressing mutant human α1-antitrypsin. Hepatology 2017 Apr;65(4):1319-1335. doi: 10.1002/hep.29027. Epub 2017 Feb 25. PMID: 28056498.
  • Pastore N, Attanasio S, Granese B, Castello R, Teckman J, Wilson AA, Ballabio A, Brunetti-Pierri N. Activation of the c-Jun N-terminal kinase pathway aggravates proteotoxicity of hepatic mutant Z alpha1-antitrypsin. Hepatology. 2017 Jan 10. doi: 10.1002/hep.29035. PMID: 28073160
  • Di Bisceglie AM, Lombardero M, Teckman J, Roberts L, Janssen HL, Belle SH, Hoofnagle JH; Hepatitis B Research Network (HBRN). J Viral Hepat. Determination of hepatitis B phenotype using biochemical and serological markers 2017 Apr;24(4):320-329. doi: 10.1111/jvh.12643. Epub 2016 Dec 5. PMID: 27917600
  • Jain AK, Sharma A, Arora S, Blomenkamp K, Jun IC, Luong R, Westrich DJ, Mittal A, Buchanan PM, Guzman MA, Long J, Neuschwander-Tetri BA,Teckman J. Preserved gut microbial diversity accompanies upregulation of TGR5 and hepatobiliary transporters in bile acid treated animals on Parenteral Nutrition. Journal of Parenteral and Enteral Nutrition. 2016 Aug 8. pii: 0148607116661838. PMID: 27503935.
  • Greene CM, Marciniak SJ, Teckman JH, Farraroti I, Brantly MJ, Lomas DA, Stoller JK, McElvaney G. Alpha-1-antitrypsin Deficiency. Nature Reviews Disease Primers. 2016 Jul 28;2:16051. doi: 10.1038/nrdp.2016.51. PMID: 27465791.
  • Tang Y, Fickert P, Trauner M, Marcus NY, Blomenkamp KS, Teckman J. Autophagy Induced by Exogenous Bile Acids is Therapeutic in a Model of Alpha-1-AT Deficiency Liver Disease. Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1;311(1):G156-65. doi: 10.1152/ajpgi.00143.2015. PMID: 27102560
  • Gaczynska M, Karpowicz P, Stuart CE, Norton MG, Teckman JH, Marszal E, Osmulski PA. AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human at Proteinase Inhibitor. PloS One. 2016 Mar 23;11(3):e0151902.
  • Baseline Analysis of a Young a-t-Antitrypsin Deficiency liver Disease Cohort Reveals Frequent Portal Hypertension. Teckman JH, Rosenthal P, Abel R, Sass LM, Michail S, Murray KF, Rudnick DA, Thomas OW, Spino C, Arnon R, Hertel PM, Heubl J, Kamath BM, Karnsakul W, loomes KM, Magee JC, Molleston JP, Romero R, Shneider Bl, Sherker AH, Sokol RJ; Childhood liver Disease Research Network (ChilDReN). J Pediatr Gastroenterol Nutr. 2015 Jul;61{1):94·101.
  • Oleanolic Acid Improves Gut Atrophy Induced by Parenteral Nutrition. Jain AK, Wen JX, Blomenkamp KS, Arora S, Blaufuss TA, Rodrigues J, Long JP, Neuschwander-Tetri BA, Teckman JH. JPEN J Parenter Enteral Nutr. 2016 Jan;40(1):67-72.
  • Schwarz K, Rosenthal P, Teckman JH, lingS, Rodriquez R, Murray K, for the Hepatitis B Research Network (HBRN). Children in the US and Canada with Chronic Hepatitis B. J Pediatr. 2015 Dec;167(6):1287-1294.e2. doi: 10.1016/j.jpeds.2015.08.021. Epub 2015 Sep 10. PMID: 26364985
  • Kamath BM, Chen Z, Romero R, Fredericks EM, Alonso EM, Arnon R, Heubi J, Hertel PM, Karpen SJ, Loomes KM, Murray KF, Rosenthal P, Schwarz KB, Subbarao G, Teckman JH, Turmelle YP,Wang KS, Sherker AH, Sokol RJ, Magee JC; Childhood Liver Disease Research Network (ChilDReN). Quality of life and Its Determinants in a Multicenter Cohort of Children with Alagille Syndrome. J Pediatr 2015. Aug;167(2):390-396.e3. doi:10.1016/j.jpeds.2015.04.077PMID:26059338
  • Jain AK, Teckman JH. Controversies in the Mechanism of Total Parenteral Nutrition Induced Pathology. Controversies in Pediatric Digestive Diseases. Children, 2, 358-370; doi:l0.3390/children2030358) 2015, Aug.ISSN 2227-9067.
  • Teckman JH, Mangalat N. Alpha-1 antitrypsin and liver disease: mechanism of injury and novel Interventions. Expert Review of Gastroenterology & Hepatology. 2015 9{2): 261-268. ISSN 1747-4124. PMID: 25066184.
  • Jain AK, Teckman JH. Wilson's Disease; in Decision Support in Medicine: Pediatrics. Barrett OJ, McMillan J, Jones 0, Boney C. eds. (Textbook on-line app).
  • Teckman JH. Chapter 9. liver Disease: Pathology, Treatment and Clinical Trials. In Alpha-1-antitrypsin Deficiency: Biology, Diagnosis, Clinical Significance and Emerging Therapies. Noor Kalsheker, Robert Stockley, eds. Elsevier Publishing.
  • Blomenkamp K, Teckman JH. AAT Monomer/Polymer Separation. In Alpha-1-Antitrypsin Deficiency: Methods and Protocols. Florie Borel, Christian Mueller, eds. Springer Protocols Publishing.
  • Teckman JH, Blomenkamp K. Pathophysiology of Alpha·l·antitrypsin Deficiency Liver Disease. In Alpha-1-Antitrypsin Deficiency: Methods and Protocols. Florie Borel, Christian Mueller, eds. Springer Protocols Publishing.
  • Teckman JH. Emerging Concepts and Human Trials in Alpha-1-Antitrypsin Deficiency Liver Disease. Seminars in Liver Disease; 37(02): 152-158. Gores G and Bruix J eds.

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