Zhenguo Lin, Ph.D.
Genomics, Bioinformatics I, Bioinformatics II
Ph.D., Pennsylvania State University
The main research interests in the Lin laboratory are in understanding the evolutionary dynamics of genomic architecture, content, and sequences in different lineages of organisms, and in elucidating its impacts on the evolution of biological novelty and diversity. These are fundamental biological questions which are also, directly and indirectly, related to many human diseases. The research activities in the lab involve generation and analysis of large collections of next-generation sequencing data, as well as using molecular biology techniques to validate results generated by bioinformatics analysis using various yeast species as model systems. Specifically, current research projects of my laboratory include:
- Identification and characterization of core promoters in yeasts using CAGE sequencing technique
- Investigating the functional significance and evolutionary dynamic of 5'UTR length
- Studying the genetic basis underlying the evolution of aerobic fermentation in yeasts
- Understanding the evolutionary dynamics of genome architecture
Labs and Facilities
Lin Lab webpage: www.zlinlab.org
Publications and Media Placements
*corresponding author, +graduate student mentee, #undergraduate student mentee
Lu Z+ and Lin Z*, The origin and evolution of a distinct mechanism of transcription initiation in yeasts. preprint available at bioRxiv doi: https://doi.org/10.1101/2020.04.04.025502
Zhang L*, Yang JR, Zhang G*, Lin Z*. Genomic variations of COVID-19 suggest multiple outbreak sources of transmission. preprint available at medRxiv doi: https://doi.org/10.1101/2020.02.25.20027953
Mersman BA, Jolly SN, Lin Z, Xu F. Gap Junction Coding Innexin in Lymnaea stagnalis: Sequence Analysis and Characterization in Tissues and the Central Nervous System. Frontiers in Synaptic Neuroscience 12.1 2020 [Full Text | PDF]
Fanter CE, Lin Z, Keenan SW, Janzen FJ, Mitchell TS, Warren DE. Development-specific transcriptomic profiling suggests new mechanisms for anoxic survival in the ventricle of overwintering turtles. Journal of Experimental Biology 2019 : jeb.213918 doi: 10.1242/jeb.213918 [Full Text | PDF]
Mullis A+, Lu Z+, Zhan Y+, Wang TY, Rodriguez J§, Rajeh A#, Chatrath A#, and Lin Z*. Concerted evolution of ribosomal protein genes in fungi and its adaptive significance. Molecular Biology and Evolution msz229; 2019 [Full Text | PDF]
Wang J, Chew BLA, Lai Y, Dong H, Xu L, Balamkundu S, Cai WM, Cui L, Liu CF, Fu XY, Lin Z, Shi PY, Lu TK, Luo D, Jaffrey SR, and Dedon PC, Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA. Nucleic Acid Research 2019, 47(20):e130, [Full Text | PDF]
McMillan J#, Lu Z+, Rodriguez JS, Ahn T-H, Lin Z*. YeasTSS: An Integrative Web Database of Yeast Transcription Start Sites. Database (Oxford); 2019 baz048, [Full Text | PDF]
Vijayraghavan S, Kozmin SG, Strope PK, Skelly DA, Lin Z, Kennell J, Magwene PM, Dietrich FS. and McCusker JH. Mitochondrial Genome Variation Affects Multiple Respiration and Non-respiration Phenotypes in Saccharomyces cerevisiae. Genetics; 2019;211(2):773-86; [Full Text ]
Chen F, Hu Y, Vannozzi A, Wu K, Cai H, Qin Y, Mullis A+, Lin Z*, and Zhang, L*. The WRKY transcription factor family in model plants and crops. Critical Reviews in Plant Sciences; 2018, 36:311-335 [Full Text | PDF]
Wang B, Han X, Bai Y, Lin Z, Qiu M, Nie X, Wang S, Zhang F, Zhuang Z, Yuan J, Wang S. Effects of nitrogen metabolism
on growth and aflatoxin biosynthesis in Aspergillus flavus. J Hazard Mater; 2017, 324(Pt B):691-700. [Full text | PDF]
Zhang L, Chen F, Zhang GQ, Zhang YQ, Niu S, Xiong JS, Lin Z, Cheng Z, Liu ZJ. Origin and mechanism of crassulacean acid metabolism in orchids
as implied by comparative transcriptomics and genomics of the carbon fixation pathway.
The Plant Journal; 2016, 86:175-185 [Full text | PDF]
Li Y, Zhang W, Zheng D, Zhou Z, Yu W, Zhang L, Feng L, Liang X, Guan W, Zhou J, Chen
J, and Lin Z*. Genomic Evolution of Saccharomyces cerevisiae under Chinese Rice Wine Fermentation.
Genome Biol Evol; 2014. 6:2516-2526 [ Full text | PDF ]
Prior to joining SLU
Lin Z and Li WH. Comparative Genomics and Evolutionary Genetics of Yeast Carbon Metabolism in Molecular Mechanisms in Yeast Carbon Metabolism J. Piškur and C. Compagno Editors. 2014 Springer Berlin Heidelberg. p. 97-120.
Zhu Y, Lin Z, and Nakhleh L. Evolution After Whole-genome Duplication: A Network Perspective. G3: Genes Genomes Genetics; 2013, 3:2049-2057
Lin Z, Wang TY, Tsai BS, Wu FT, Yu FJ, Tseng YJ, Sung HM, and Li WH. Identifying cis-regulatory changes involved in the evolution of aerobic fermentation in yeasts. Genome Biol. Evol; 2013, 5:1065-1078.
Li Y, Zhang L, Ball RL, Liang X, Li J, Lin Z, and Liang H. Comparative analysis of somatic copy-number alterations across different human cancer types reveals two distinct classes of breakpoint hotspots. Hum. Mol. Genet; 2012, 21:4957-4965
Lin Z, and Li WH. Evolution of 5’untranslated region length and gene expression reprogramming in yeasts. Mol. Biol. Evol; 2012, 29:81-89
Lin Z, and Li WH. The evolution of aerobic fermentation in Schizosaccharomyces pombe was associated with regulatory reprogramming but not nucleosome reorganization. Mol. Biol. Evol; 2011, 28:1407-1413
Lin Z, and Li WH. Expansion of hexose transporter genes was associated with evolution of aerobic fermentation in yeasts. Mol. Biol. Evol; 2011, 28:131-142
Lin Z, Wu WS, Liang H, Woo Y and Li WH. Spatial distributions of cis-regulatory elements and nucleosomes in yeast promoters and their effects on transcriptional regulation. BMC Genomics; 2010, 11:581
Zhou X, Lin Z, and Ma H. Phylogenetic detection of numerous gene duplications shared by animals fungi and plants. Genome Biology; 2010, 11:R38
Li Y, Liang H, Gu Z, Lin Z, Guan W, Zhou L, Li Y, and Li WH. Detecting positive selection in the budding yeast genome. J Evol Biol; 2009, 22:2430.
Lin Z*, Ma H, and Nei M. Ultraconserved coding regions outside the homeobox of mammalian Hox genes. BMC Evol Biol; 2008, 8:260.
Lin Z, Nei M, and Ma H. The origins and early evolution of DNA mismatch repair genes: multiple horizontal gene transfers and co-evolution. Nucleic Acids Res; 2007, 35 7591-7603.
Lin Z, Kong H, Nei M, and Ma H. Origins and evolution of the recA/RAD51 gene family: evidence for ancient gene duplication and endosymbiotic gene transfer. Proc. Natl. Acad. Sci. USA; 2006, 103:10328-10333.
Li W, Yang X, Lin Z, Timofejeva L, Xiao R, Makaroff CA, and Ma H. TheAtRAD51C gene is required for normal meiotic chromosome synapsis and double-stranded break repair in Arabidopsis. Plant Physiol; 2005, 138:965-976.