Judith Ogilvie, Ph.D.
Developmental Biology, Signal Transduction, Cell Biology Laboratory, Introduction to Biology, Sensory Neuroscience
Ph.D., Harvard University
Research in Ogilvie's laboratory focuses on vertebrate photoreceptor development, degeneration, and protection. Retinitis pigmentosa (RP), a photoreceptor degenerative disease, is the leading cause of inherited blindness. The rd1 mouse is an animal model of this disease with delayed photoreceptor development and early onset degeneration. Although the genetic defect in the rd1 mouse is known, the molecular cascade leading to the death of the photoreceptor cells is poorly understood. The long term objective of her laboratory is to understand the molecular cascade of events required for differentiation of healthy photoreceptor cells and how defects in this cascade can lead to blindness. A better understanding of the molecular biology of photoreceptor development provides the potential for treatment of disease by altering the molecular signals.
Labs and Facilities
Research projects in Ogilvie's lab include the opportunity to study an animal model of human disease using a variety of morphological, cellular, and molecular techniques. Students interested in cell biology, neurobiology, development, or vision should talk with her about current research opportunities in my laboratory.
Publications and Media Placements
Zhang, J., A.M. Richmond, J.M. Ogilvie (2014) "Inhibition of dopamine signaling suppresses cGMP accumulation in rd1 retinal organ cultures." NeuroReport. 25:601-606. DOI: 10.1097/WNR.0000000000000145. PMID: 24614363. PMCID: 4275426.
Dickison, V.M., A.M. Richmond, A. Abu Irqeba, J.G. Martak, S.C.E. Hoge, M.J. Brooks, M.I. Othman, R. Khanna, A.J. Mears, A.Y. Chowdhury, A. Swaroop, J.M. Ogilvie. (2012) "A role for prenylated rab acceptor 1 in vertebrate photoreceptor development." BMC Neuroscience. 13:152. DOI: 10.1186/1471-2202-13-152. Designated as a "Highly Accessed Article."
Ogilvie, J.M., A.M. Hakenewerth, R.R. Gardner, J.G. Martak, V.M. Maggio (2009) Dopamine receptor
loss of function is not protective of rd1 rod photoreceptors in vivo. Mol. Vision. 15:2868-2878. http://www.molvis.org/molvis/v15/a303
Heldermon, C.D., A.K. Hennig, K.K. Ohlemiller, J.M. Ogilvie, E.D. Herzog, A, Breidenbach, C. Vogler, D.F. Wozniak, M.S. Sands (2007). Development of sensory, motor and behavioral deficits in the murine model of Sanfilippo syndrome type B. PLoS ONE. 2(8): e772. doi:10.1371/journal.pone.0000772. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0000772
Ogilvie, J.M., K.K. Ohlemiller, G.N. Shah, B. Ulmasov, T.A. Becker, A. Waheed, A.K. Hennig, P.D. Lukasiewicz, W.S. Sly (2007). Carbonic anhydrase XIV deficiency produces a functional defect in the retinal light response. Proc. Nat. Acad. Sci. 104:8514-8519. http://www.pnas.org/content/104/20/8514.full
Liu, Y., L. Xu, A.K. Hennig, A. Kovacs, A. Fu, S. Chung, D. Lee, B. Wang, J.M. Ogilive, S.-R. Cai, and K.P. Ponder (2005). Liver-directed Neonatal Gene Therapy Prevents Cardiac, Bone, Ear, and Eye Disease in Mucopolysaccharidosis I Mice. Molecular Therapy 11:35-47.
Griffey, M., S.L. Macauley, J.M. Ogilvie, M.S. Sands. (2005) AAV-mediated ocular gene therapy for infantile neuronal ceroid lipofuscinosis (INCLs). Molecular Therapy 12:413-21.
Hennig, A.K., J.M. Ogilvie, K.K. Ohlemiller, A.M. Timmers, W.W. Hauswirth, and M.S. Sands (2004). AAV-Mediated intravitreal gene therapy reduces lysosomal storage in the retinal pigmented epithelium and improves retinal function in adult MPS VII mice. Molecular Therapy 10:106-116.
Hennig, A.K., B. Levy, J.M. Ogilvie, C.A. Vogler, N. Galvin, S. Bassnett, and M.S. Sands (2003). Intra-vitreal gene therapy reduces lysosomal storage in the brains of mucopolysaccharidosis VII mice. Journal of Neuroscience 23:3302-3307.
Rohrer, B. and J.M. Ogilvie (2003). Retarded Outer Segment Development in TrkB Knockout Mouse Retina Organ Culture. Molecular Vision 9:18-23.
Wang, Y., S.B. Smith, J.M. Ogilvie, D.J. McCool, and V. Sarthy (2002). Cytokines Activate JAK/STAT Signal Transduction Cascade and Induce Intermediate Filament Protein Expression in Retina. Current Eye Research24:305-312.
Ogilvie, JM and JD Speck (2002). Dopamine has a critical role in photoreceptor degeneration in the rd mouse. Neurobiology of Disease 10:33-40.
Ogilvie, JM (2001). Photoreceptor Rescue in an Organotypic Model of Retinal Degeneration. Progress in Brain Research 131:641-648.
Ogilvie, JM, JD Speck, JM Lett (2000). Growth Factors In Combination, But Not Individually, Rescue rd Mouse Photoreceptors in Organ Culture. Experimental Neurology 161:676-685.
Mosinger Ogilvie, JM, JD Speck, JM Lett, TT Fleming (1999). A reliable method for organ culture of neonatal mouse retina with long-term survival. Journal of Neuroscience Methods 87:57-65.
Mosinger Ogilvie, JM, TL Deckwerth, CM Knudson, SJ Korsmeyer (1998). Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice. Investigative Ophthalmology and Visual Science 39:1713-1720.