Laurie Shornick, Ph.D.
Principles of Virology, Advanced Principles of Virology, Foundations of Immunobiology, Concepts of Immunobiology
The first project in Shornick's lab is to explore the neonatal immune response to respiratory viral infection. Infants are especially vulnerable to viral infections. This is due, in part, to an immature immune system. The laboratory uses a mouse model of viral infection to elucidate the cellular and molecular differences between the neonatal and adult immune response to viral infection. She is also interested in how immune factors in maternal milk may modulate the neonatal immune response.
The second research project in Shornick's lab is aimed at understanding why wound healing is impaired in diabetic patients. Delayed wound healing in diabetic patients results in many amputations, and has a significant effect on the quality of life for these patients. Shornick is examining the differences in immune cell activation during the course of normal and diabetic wound healing.
Labs and Facilities
For more information, see Shornick's laboratory webpage.
Publications and Media Placements
Carpenter KJ, Valfort AC, Steinauer N, Chatterjee A, Abuirqeba S, Majidi S, Sengupta M, Di Paolo RJ, Shornick LP, Zhang J, Flaveny CA. LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer. Sci Rep. 2019 Dec 20;9(1):19530.
Lawrence DW, Shornick LP, Kornbluth J. Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model. PLoS One. 2019 Sep 20;14(9):e0222802. doi: 10.1371/journal.pone.0222802. eCollection 2019
Yong Zhang, Dailing Mao, Shamus P. Keeler, Xinyu Wang, Kangyun Wu, Benjamin J. Gerovac, Laurie P. Shornick, Eugene V. Agapov and Michael J. Holtzman. Respiratory Enterovirus (Like Parainfluenza Virus) Can Cause Chronic Lung Disease If Protection by Airway Epithelial STAT1 Is Lost. Journal of Immunology, 2019, 202: 000–000 doi.org/10.4049/jimmunol.1801491
Tumala B, Phelps KR, Zhang S, Bhattacharya S, Shornick LP. (2018) Prostaglandin D2 Levels Regulate CD103+ Conventional Dendritic Cell Activation
in Neonates During Respiratory Viral Infection. Viral Immunol. Vol. 31, No. 10, Nov
7. doi: 10.1089/vim.2018.0090
Hixon, KR, Dunn AJ, Flores, R, Minden-Birkenmaier, BA, Growney Kalaf, EA, Shornick, LP, Sell SA (2017) Using Electrospun Scaffolds to Promote Macrophage Phenotypic Modulation and Support Wound Healing. Electrospinning 2:1-15.
Kadakia, PU, Growney Kalaf, EA, Dunn, AJ, Shornick LP, and Sell, SA. (2017) Comparison of silk fibroin electrospun scaffolds withpoloxamer and honey additives for burn wound applications. Journal of Bioactive and Compatible Polymers, Journal of Bioactive and Compatible Polymers 33(8):088391151771066
Finley P.J., DeClue C.E., Sell S.A., DeBartolo, J.M., Shornick L.P. (2016) Diabetic Wounds Exhibit Decreased Ym1 and Arginase Expression with Increased Expression of IL-17 and IL-20 Advances in Wound Care (New Rochelle). Nov 1;5(11):486-494.
DeClue C.D., and Shornick L.P.. (2015) The cytokine milieu of diabetic wounds. Diabetes Management 5(6): 525-537.
Maternal inflammation modulates infant immune response patterns to viral lung challenge in a murine model. Gleditsch DD, Shornick L.P., Van Steenwinckel J, Gressens P, Weisert RP, Koenig JM. Pediatr Res. 2014 Apr 11. doi: 10.1038/pr.2014.57. [Epub ahead of print]
Pillars article: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994. 264: 703-707.
De Togni P, Goellner J, Ruddle NH, Streeter PR, Andrea F, Mariathasan S, Smith SC,
Carlson R, Shornick L.P., Strauss-Schoenberger J, Russell JH, Karr R, Chaplin DD.
J Immunol. 2014 Mar 1;192(5):2010-4.
Silver dressings improve diabetic wound healing without reducing bioburden. Finley, P.J., Huckfeldt, R.E., Walker, K.D., Shornick, L.P. Wounds Volume 25, Issue 10, October 2013, Pages 293-301.
Bhattacharya, S., Beal, B.T., Janowski, AM, Shornick, L.P. (2011) Reduced inflammation and altered innate response in neonates during paramyxoviral infection. Virology Journal 8(1):549.
Anbukumar D.S., Shornick L.P., Albert C.J., Steward M.M., Zoeller R.A., Neumann W.L., Ford D.A. (2010) Chlorinated
lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal.
J Lipid Res. 51(5):1085-92.
Shornick, L.P., Zhang, Y., Huang, G., Sosa, M., Shukla, N., Agapov, E., Holtzman, M.J. (2008) Airway Epithelial versus Immune Cell Stat1 Function for Innate Defense against Respiratory Viral Infections. Journal of Immunol., 180(5):3319-28.
Zhang, Y., Huang, G., Shornick, L.P., Roswit, W.T., Brody, S.L. Holtzman, M.J. (2007) Transgenic FoxJI-Cre mediates recombination in ciliated cells. Am. J. Resp. Cell & Molec. Biol., 36(5):515-519.
Deppong, C., Juehne, T.I., Hurchla, M., Friend, L.D., Shah, D.D., Rose, C.M., Bricker, T.L., Shornick, L.P.,Crouch, E.C., Murphy, T.L., Holtzman, M.J., Murphy, K.M., Green, J.M. (2006) BTLA and PD-1 Inhibitory Receptors are Required for Termination of Acute Allergic Airway Inflammation. J. Immunol., 176 (7): 3909-13.
Holtzman M.J., Tyner J.W., Kim E.Y., Lo M.S., Patel A.C., Shornick L.P., Agapov E., Zhang Y. (2005) Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2(2):132-40.
Holtzman M.J., Kim E.Y., Lo M.S., Tyner J.W., Shornick L.P., Sumino K.C., Zhang Y. (2005) Defining and adjusting divergent host responses to viral infection. Immunol Res. 32:123-42.
Holtzman, M.J., Shornick, L.P., Grayson, M.H., Kim, E.Y., Tyner, J.W., Patel, A.C., Agapov, E., Zhang, Y. (2004) Hit-and-run effects of paramyxoviruses as a basis for chronic airway disease. Ped. Infect. Dis. J., 23:S235-45.
Verbsky, J.W., Randolph, D. A., Shornick, L.P., Chaplin, D.D. (2002) Non-hematopoietic expression of Janus Kinase 3 is required for efficient recruitment of Th2 lymphocytes and eosinophils in OVA-induced airway inflammation. J. Immunol. 168:2475-2482.
Holtzman, M.J., Morton, J.D., Shornick, L.P., Tyner, J.W., O'Sullivan, M.P., Antao, A., Lo, M., Castro, M. and Walter, M.J. (2002) Immunity, Inflammation, and Remodeling in the Airway Epithelial Barrier: Epithelial-Viral-Allergic Paradigm. Physiol. Rev. 82:19-46.
Shornick, L.P., Bisarya, A.K, Chaplin, D. D. (2001) IL-1beta is essential for Langerhans cell activation and antigen delivery to the lymph nodes during contact sensitization: evidence for a dermal source of IL-1beta, Cellular Immunol. 211:105-112.
Shornick, L.P., De Togni, P., Mariathasan, S., Goellner, J., Strauss-Schoenberger, J., Karr, R., Ferguson, T., Chaplin, D. D. (1996) Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzene. J. Exp. Med. 183: 1427-1436.
De Togni, P., Goellner, J., Ruddle, N.H., Streeter, P.R., Fick, A., Mariathasan, S., Carlson, R., Shornick, L.P., Strauss-Schoenberger, J., Russell, J. H., Karr, R., and Chaplin, D. D. (1994) Abnormal development of peripheral lymphoid organs in lymphotoxin deficient mice. Science 264: 703-707.
Hussain, H., Shornick, L.P., Shannon, V.R., Wilson, J.D., Funk, C.D., Pentland, A.P. and Holtzman, M.J. (1994) Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. Am. J. Physiol. 266:C243-C253.
Shornick, L.P. and Holtzman, M.J. (1993) A cryptic, microsomal-type arachidonate 12-lipoxygenase is tonically inactivated by oxidation-reduction conditions in cultured epithelial cells. J. Biol. Chem. 268:371-376.
Holtzman, M.J., Turk, J., Shornick, L.P. (1992) Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells. J. Biol. Chem. 267: 21438-21445.