The symposium is intended to bring together faculty with complementary research interests to further the wound healing community at Saint Louis University, throughout the city of St. Louis, and the region. The symposium will be held from 9 a.m. to noon, Friday, Dec. 9, in the ninth-floor conference room of the Doisy Research Center on SLU's south campus.
This year's keynote speaker is Bryan Brown, Ph.D., from the University of Pittsburgh. Brown is an assistant professor in the Department of Bioengineering with a secondary appointment in the Department of Obstetrics, Gynecology, and Reproductive Sciences at the University of Pittsburgh. His lab aims to couple a mechanistic understanding of the host inflammatory response in injury and disease with the development of context-dependent biomaterials for regenerative medicine strategies.
Brown will present "A Macrophage Centric Approach to the Tissue Reconstruction and Regenerative Medicine."
Abstract: Regenerative medicine, a multi-disciplinary approach that seeks to restore form and function to damaged or diseased tissues and organs, has evolved significantly during the past decade. By adapting and integrating fundamental knowledge from cell biology, polymer science, and engineering, coupled with an increasing understanding of the mechanisms which underlie the pathogenesis of specific diseases, regenerative medicine has the potential for innovative and transformative therapies for heretofore unmet medical needs. However, the translation of novel technologies from the benchtop to animal models and clinical settings is non-trivial and requires an understanding of the mechanisms by which the host will respond to these novel therapeutic approaches. The role of the innate immune system, especially the role of macrophages, in the host response to regenerative medicine based strategies has recently received considerable attention. Macrophage phenotype and function have been suggested as critical and determinant factors in downstream outcomes. The constructive and regulatory, and in fact essential, role of macrophages in positive outcomes represents a significant departure from the classical paradigms of host-biomaterial interactions, which typically consider activation of the host immune system as a detrimental event. It now appears desirable that emerging regenerative medicine approaches should not only accommodate but also promote the involvement of the immune system to facilitate positive outcomes. As such, improving of our understanding of context-dependent macrophage polarization will lead to the development of novel approaches to tissue reconstruction and regeneration with concurrent improvements in outcomes.
Abstracts are due by 5 p.m., Wednesday, Nov. 23. Oral presentations (Seven to 15 minutes in duration, depending on the number of abstracts received) will be chosen from the abstracts received, and a schedule of presenters will be released on Dec. 2. Submit all abstracts via email to Scott Sell, Ph.D. (firstname.lastname@example.org). For further information, contact symposium organizers Laurie Shornick, Ph.D. (email@example.com) or Scott Sell, Ph.D. (firstname.lastname@example.org).