Maurice Green, Ph.D., a researcher at Saint Louis University for more than six decades
and among the first scientists to use viruses to shed light on what goes on inside
cells, died on Tuesday, Dec. 5, after an illness. He was 91.
Green was a pioneer in using viruses as a probe to understand the biology of normal
cells and how cancer works on the molecular level. He studied the adenovirus, and
through his lab, developed the first working model of the virus. His interest in science
began when he was stationed in the Philippines during World War II, and said he had
nothing to do but read about medicine.
Green joined the faculty of Saint Louis University School of Medicine 61 years ago
as an assistant professor of microbiology. After becoming an associate, then full
professor of microbiology, Green became the founding chair of the Institute for Molecular
Virology in 1964.
Green coined the term “molecular virology,” and the techniques developed in his lab
contributed to the evolution of the field into an integral part of medical education.
He pioneered the methodology used to better understand how to study viruses, what
viruses are, and how viruses infect cells to convert them into a factory of replication.
“For over 45 years, Maurice was my boss, my mentor, my colleague and my friend,” said
Paul Loewenstein, assistant research professor. “He taught me the excitement of science
– that science was fun, seeking knowledge was fun, looking at data for the first time
was a thrill.
An important note that says volumes about Green: His current CV of well over 300
papers does not yet include the most recent one to be published in Genes & Cancer.
“We received notice of its acceptance last Tuesday (the week before Green died).
His colleague Ling-jun Zhao, Maurice and I worked on that manuscript. His fingerprints
are all over that paper, which we haven’t gotten back in galleys yet,” Loewenstein
said.
Green made those who he worked with at every level understand their contribution to
the success of his research team, Loewenstein said.
“Years ago, a dishwasher in the lab worked until she was in her 90s. When people asked
why she continued to work, she said she did it because ‘Dr. Green makes me feel like
I’m part of the important work that is being done here,’” Loewenstein said.
Green trained countless graduate and post-doctoral students, including SLU medical
school senior researcher scientists Govindaswamy Chinnadurai, Ph.D., Duane Grandgenett,
Ph.D., and William Wold, Ph.D., chair of molecular microbiology and immunology.
Green’s research into the role of viruses in cancer was funded by the National Institutes
of Health as part of President Richard Nixon’s “War on Cancer.” A guest at Nixon’s
signing of the National Cancer Act into law in 1971, Green was given one of the pens
used by Nixon. With funding from the NIH and support from SLU, the Institute for Molecular
Virology grew into a hub of research activity.
“Maurice attracted ambitious scientists to SLU. When I came aboard, Maurice had 20
post-doc fellows and 60 people worked in the Institute of Molecular Virology. The
parking lot was full of eager researchers, working seven days a week,” Wold said.
“Maurice was the head of that dynamism – himself working 10 to 12 hours a day, seven
days a week -- and an awful lot of research was conducted in that building. There
might have been 10 to 20 people worldwide of Maurice’s stature who studied cancer
and viruses, and he was right here at SLU.”
Green was frequently accompanied by one of his “laborador-y” retrievers, who were
protective of his work, Wold said.
Green drove fancy cars including a Corvette, and MG and Mercedes, swam every day,
loved to fish, maintained aquariums at home and in his office, and taught himself
to type at an advanced age so he could use a computer keyboard. He loved electronic
gadgets and had a collection of many cameras.
“I never saw any photo albums, but he loved to have the latest camera equipment, technology
and gadgets,” Wold said.
Green was an “all-in” kind of person who left a legacy through his research and through
his highly successful children who all pursued careers in science and medicine, he
added.
Green is survived by three children: Michael R. Green, M.D., Ph.D., a molecular and
cancer biologist researcher at the Howard Hughes Medical Institute at the University
of Massachusetts Medical School; Wendy A. Green, M.D., a pediatrician; and Eric Green,
M.D., Ph.D., director of the NIH’s National Human Genome Research Institute; and five
grandchildren.
Green became the founding chair of the Institute for Molecular Virology in 1964.
