In Absence of Obesity, PTSD Patients Not at Higher Risk of Type 2 Diabetes
ST. LOUIS – Saint Louis University research finds post-traumatic stress disorder does
not directly lead to type 2 diabetes mellitus (T2DM), instead obesity in PTSD patients
accounts for the increased risk.
The study, “The Role of Obesity in the Association Between Posttraumatic Stress Disorder
and Incident Diabetes” was published Aug. 8 in JAMA Psychiatry.
Post-traumatic stress disorder is associated with risk factors for type 2 diabetes,
including poor diet, lack of exercise, alcohol abuse and obesity. The risk factors
may interact with hypothalamic-pituitary-adrenal changes to increase the risk of type
Numerous studies over the past two decades have indicated patients with PTSD have
an increased risk of developing type 2 diabetes compared to those without PTSD or
without a mental health condition, said study author Jeffrey Scherrer, Ph.D., professor
of family and community medicine at Saint Louis University.
“While these studies have simultaneously controlled for obesity and other diabetes
risk factors, none have teased out the independent effect of obesity on the PTSD to
incident diabetes association,” Scherrer said.
The current study by Scherrer and his co-authors was designed to determine if obesity,
which is more common in patients with PTSD, accounted for the increased risk of diabetes.
The retrospective cohort study used medical record data collected between 2008-2015
from 2,204 Veterans Health Affairs patients without PTSD and 3,450 patients with PTSD. Of
the patients without PTSD, 84.4 percent were men, 64.7 were white and 43.4 percent
were married. The average age of the patients was 47.7 years.
Of the cohort of patients with PTSD, 86.5 percent were men, 64.9 percent were white
and 44.2 percent were married. The average age of the patients was 42.8 years.
The age adjusted association between PTSD and incident T2DM was significant. After
adjusting for obesity, the association was reduced and no longer statistically significant.
Results of the full model, which included additional covariate adjustment revealed
no association between PTSD and incident type 2 diabetes.
The incidence of type 2 diabetes was similar in patients with PTSD and obesity compared
to patients without PTSD but obese. Likewise, Scherrer said, the incidence of diabetes
in non-obese patients with and without PTSD was similar (5.8/1000 person years (PY)
and 6.4/1000PY, respectively).
“The risk of diabetes in patients with PTSD who are not obese is like that of the
general U.S. population without obesity,” Scherrer said.
Diabetes prevention should target weight management for both patients with and without
PTSD. However, Scherrer says, evidence that patients with PTSD have greater difficulty
losing weight may require new interventions to help manage weight and mitigate risk
of developing diabetes.
The study calls for additional research to determine if PTSD remission can lead to
weight loss and reduced incidence of type 2 diabetes.
Other authors include Joanne Salas, MPH, of the Department of Family and Community
Medicine at Saint Louis University and Harry S. Truman Veterans Administration Medical
Center, Columbia, Missouri; Patrick J. Lustman, Ph.D., Department of Psychiatry, Washington
University School of Medicine, St. Louis, Missouri; Carissa van den Berk-Clark, Ph.D.,
Department of Family and Community Medicine at Saint Louis University; Paula P. Schnurr,
Ph.D., Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover,
New Hampshire and National Center for PTSD, White River Junction, Vermont; Peter Tuerk,
Ph.D., Department of Psychiatry and Behavioral Sciences, Medical University of South
Carolina, Charleston, South Carolina and Ralph H. Johnson VA Medical Center, Charleston,
South Carolina; Beth E. Cohen, M.D., MAS, Department of Medicine, University of California
San Francisco School of Medicine, San Francisco California and San Francisco VA Medical
Center, San Francisco, California; Matthew J. Friedman, M.D., Ph.D., National Center
for PTSD, White River Junction, Vermont; Sonya B. Norman, Ph.D., Department of Psychiatry,
University of California San Diego, San Diego, California and National Center for
PTSD, White River Junction, Vermont; F. David Schneider, M.D. MSPH, Department of
Family and Community Medicine, University of Texas Southwestern, Dallas Texas; and Kathleen
M. Chard, Ph.D., Department of Psychiatry and Behavioral Neuroscience, University
of Cincinnati, Cincinnati, Ohio and Trauma Recovery Center Cincinnati VA Medical Center,
This study was supported by the National Heart Lung and Blood Institute, R01HL125424.
Established in 1836, Saint Louis University School of Medicine has the distinction
of awarding the first medical degree west of the Mississippi River. The school educates
physicians and biomedical scientists, conducts medical research, and provides health
care on a local, national and international level. Research at the school seeks new
cures and treatments in five key areas: cancer, liver disease, heart/lung disease,
aging and brain disease, and infectious diseases.