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Publications & Awards

Research from the Institute for Translational Neuroscience has been the subject of many publications and awards. This page continues a list of these prestigious recognitions. 


  • Bruns J, Egan T, Mercier P, Zustiak SP. Glioblastoma spheroid growth and chemotherapeutic responses in single and dual-stiffness hydrogels. Acta Biomater. 2022 Jun 1:S1742-7061(22)00324-5. doi: 10.1016/j.actbio.2022.05.048. Epub ahead of print. PMID: 35659918.
  • Dedert, C., Mishra, V., Aggarwal, G., Nquyen, A.D., Xu, F. (2022) Proganulin Preserves Autophagy Flux and Mitochondrial Function in Rat Cortical Neurons Under High Glucose Stress. Front. Cell. Neurosci. Sec. Cellular Neuropathology. Doi:
  • Pemberton, K., Rosato, M., Dedert, C., DeLeon, C., Arnatt, C., Xu, F. (2022) Differential Effects of the G Protein-Coupled Estrogen Receptor (GPER) on Rat Embryonic (E18) Hippocampal and COrtical Neurons. ENEURO 4 July 2022, 9 (4) .0475-21.2022; DOI:
  • Squillace S, Niehoff M., Doyle TM, Green M, Esposito E, Cuzzocrea S, Arnatt C., Spiegel S, Farr S, Salvemini D. Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairments. J Clin Invest 2022 in press.
  • Fenglian Xu (Biology), first author Cass Dedert (Biology) and co-authors Vandana Mishra (Biology), Geetika Aggarwal (Pharm/Phys), and Andy Nguyen (Geriatrics) published "Progranulin Preserves Autophagy Flux and Mitochondrial Function in Rat Cortical Neurons Under High Glucose Stress" in Frontiers in Cellular Neuroscience.
  • F. Z. Tegou, D. Velluto, A. A. Stock, S. Fitzgerald, #S. Stealey, S. P. Zustiak, A. L. Bayer, *A. A. Tomei, “Immunoengineered Hydrogel Platform for Controlled Delivery of CCL21 and Beta-Cell Antigens as Tolerance-Inducing Therapy in Type I Diabetes”, Journal of Controlled Release, 2022, 348, 499-517 (IF: 11.467)
  • Cifarelli V, Peche V, Abumrad NA (2022). Vascular and Lymphatic Regulation of Gastrointestinal Function and Disease Risk. BBA Molecular and Cell Biology of Lipids, July 23 2022, DOI:
  • Squillace S and Salvemini D, Toll-like receptor-mediated neuroinflammation: relevance for cognitive dysfunctions, Trends Pharmacol Sci, 2022 June 26,23:S0165-6147(22)00127-4. doi:10.1016/
  • Moe Watanabe, Caroline M. Kopruszinski, Aubin Moutal, Daigo Ikegami, Rajesh Khanna, Yanxia Chen, Sarah Ross, Kimberly Mackenzie, Jennifer Stratton, David W. Dodick, Edita Navratilova, Frank Porreca, Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine, Brain, 2022;awac104
  • Hisakatsu Ito, Edita Navratilova, Barbora Vagnerova, Moe Watanabe, Carol Kopruszinski, Luiz H. Moreira de Souza, Xu Yue, Daigo Ikegami, Aubin Moutal, Amol Patwardhan, Rajesh Khanna, Mitsuaki Yamazaki, Miguel Guerrero, Hugh Rosen, Ed Roberts, Volker Neugebauer, David W. Dodick, Frank Porreca, Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signaling to promote wakefulness and vigilance, Brain, 2022; awac15
  • Mollasalehi N, Francois-Moutal L, Porciani D, Burke DH, Khanna M. Aptamers Targeting Hallmark Proteins of Neurodegeneration. Nucleic Acid Ther. 2022 Apr 22. Epub ahead of print. PMID: 35452303
  • Kimberly Gomez, Cheng Tang, Bin Tan, Samantha Perez-Miller, Dongzhi Ran, Santiago Loya, Aida Calderon-Rivera, Harrison Stratton, Paz Duran, Kyleigh Masterson, Anna Gabrielsen, Omar Alsbiei, Angie Dorame, M(co-Pl)aria Serafini, Aubin Moutal, Jun Wang, and Rajesh Khanna: Stereospecific effects of benzimidazolonepiperodine compounds on T-type Ca2+ channels and pain ACS Chemical Biology
  • Zhenghao Xu, Yi Wang, and Aubin Moutal: Editorial: Complementary/Alternative Therapies for Epilepsy and Related Psychiatric Comorbidities. Frontier in Neuroscience
  • Griffett K, Hayes M, Diaz G, Appourchaux K, Sanders R, Boeckman M, Koelblen T, Zhang J, Schulman IG, Elgendy B, Burris, T (2022) Antihyperlipidemic Activity of Gut-Restricted LXR Inverse Agonists. ACS Chem Biol. 2022 Apr 13. doi: 10.1021/acschembio.2c00057. Epub ahead of print. PMID: 35417135.
  • Singh AK, Mahalingam R, Squillace S, Jacobson KA, Tosh DK, Dharmaraj S, Farr SA, Kavelaars A, Salvemini D, Heijnen CJ: Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice. Acta Neuropathologica Communications 2022, 10:11.
  • Chelsea DeLeon, Kyle Pemberton, Michael Green, Vanja Kalajdzic, Martina Rosato, Fenglian Xu, and Christopher Arnatt, Novel GPER Agonist, CITFA, Increases Neurite Growth in Rat Embryonic (E18) Hippocampal Neurons, ACS Chemical Neuroscience Article ASAP, DOI: 10.1021/acschemneuro.1c00811
  • ROSSITER, J.L., Redlinger, L.J., Kolar, G.R., Samson, W.K., Yosten, G.L.C. The actions of C-peptide in HEK293 cells are dependent upon insulin and extracellular glucose concentrations. Peptides 150: 270728, 2022.
  • SAMSON, W.K., Yosten, G.L.C., Remme, C.A. A primer on obesity-related cardiomyopathy. Physiological Reviews 102(1): 1-6, 2022.
  • SAMSON, W.K., Yosten, G.L.C. A comprehensive review of the neuroscience of ingestion. Physiological Reviews 102(1): 319-322, 2022
  • Braden, K., Stratton H.J., Salvemini, D. and Khanna, R. Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain. Neurobiol Pain 11:100082, 2022.
  • Steinauer N, Zhang K, Guo C, Zhang J. Computational modeling of gene-specific transcriptional repression, activation and chromatin interactions in leukemogenesis by LASSO-regularized logistic regression. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 18(6):2109-2122, 2022.
  • Leduc-Pessah, H., Xu, C, Fan, C.Y., Dalgarno, R., Kohro, Y., Sparanese, S., Burke, N.N., Jacobson, K.A., Altier C., Salvemini, D., Trang T. Spinal A(3) adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats. J Neurosci Res 2022, 100:251-64.
  • Ghoshal S, Mukherjee S, Chakraborty M, Msengi EN, Haubner J, Chakraborty A. Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction. Int J Mol Sci. 2022;23(4):2059. Published 2022 Feb 12.
  • Wen Z, Salmaso V, Jung YH, Phung NB, Gopinatth V, Shah Q, Patterson AT, Randle JCR, Chen Z, Salvemini D, Lieberman DI, Whitehead GS, Karcz TP, Cook DN, Jacobson KA. Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y14R Antagonist. J Med Chem. 2022;65(4):3434-3459. Published 2022 Feb 24.
  • Sur S, Steele R, Ko BCB, Zhang J, Ray RB. Long non-coding RNA ELDR promotes cell cycle progression in normal oral keratinocytes through induction of a CTCF-FOXM1-AURKA signaling axis. J Biol Chem. 2022 Apr 1:101895.
  • Zhou Y, Mukherjee S, Huang D, Chakraborty M, Gu C, Zong G, Stashko MA, Pearce KH, Shears SB, Chakraborty A*, Wang H*, Wang X*. Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions. J Med Chem. 2022 Apr 25. doi: 10.1021/acs.jmedchem.2c00220. Epub ahead of print. PMID: 35467861
  • Stealey, Samuel, Mariam Khachani, and Silviya P. Zustiak. 2022. "Adsorption and Sustained Delivery of Small Molecules from Nanosilicate Hydrogel Composites" Pharmaceuticals 15, no. 1: 56.
  • Lauro,F., Giancotti, L.A., Kolar, G., Harada, C.M., Harmon,  T.A.,  Garrett, T.J., and Salvemini, D. Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities. Cell Mol Neurobiol, 2021.
  • Mukherjee S, Chakraborty M, Ulmasov B, McCommis K, Zhang J, Carpenter D, Msengi EN, Haubner J, Guo C, Pike DP, Ghoshal S, Ford DA, Neuschwander-Tetri BA, Chakraborty A. Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis. Mol Metab. 2021 Dec;54:101364.
  • Sheth, Stealey, Morgan,  Zustiak, Microfluidic Chip Device for In Situ Mixing and Fabrication of Hydrogel Microspheres via Michael-Type Addition; Langmuir 2021 37 (40), 11793-11803 DOI: 10.1021/acs.langmuir.1c01739
  • Eric Marin, Shizuka Tomatsu, Rita Khoury,  George T. Grossberg, Sleep disorders in older adults, Current Psychiatry. 2021 March;20(3):30-38 | doi:10.12788/cp.0098
  • Khoury R, Marx C, Mirgati S, Velury D, Chakkamparambil B, Grossberg GT, AVP-786 as a promising treatment option for Alzheimer's Disease including agitation Expert Opin Pharmacother.  2021 May;22(7):783-795. doi: 10.1080/14656566.2021.1882995. Epub 2021 Feb 26.  PMID: 33615952
  • Liberty François-Moutal, David Scott, Andrew Ambrose et al. Heat Shock Protein Grp78/BiP/HspA5 Binds Directly to TDP-43 and Mitigates Toxicity Associated with Neurodegenerative Disease Pathology, 08 December 2021, PREPRINT (Version 1) available at Research Square
  • Chinnaswamy K, DeMarco DM, Grossberg GT, Doll therapy in dementia: Facts and controversies,  Ann Clin Psychiatry. 2021 Feb;33(1):58-66. doi: 10.12788/acp.0010. PMID: 33125455
  • Martina Rosato, Brittany Hoelscher, Zhenguo Lin, Chidera Agwu, Fenglian Xu (2021) Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages. BMC Genomics 22 (1): 637. 637. DOI: 10.1186/s12864-021-07946-y
  • Yosten, G.L.C., G.R. Kolar, D. Salvemini, and W.K. Samson. 2021. The Deductive Reasoning Strategy Enables Biomedical Breakthroughs. Mo Med 118:352.
  • Squillace, S., and Salvemini, D., 2021. Nitroxidative stress in pain and opioid-induced adverse effects: therapeutic opportunities. Pain (In press)
  • Salvemini, D. 2021. Center for Neurosciences Responsive to Jesuit Catholic Mission of Saint Louis University. Mo Med 118:325.
  • Doyle, T.M., and D. Salvemini. 2021. Mini-Review: Mitochondrial dysfunction and chemotherapy-induced neuropathic pain. Neurosci Lett 760:136087.
  • Doyle, T.M., K. Braden, C.M. Harada, F. Mufti, R.M. Schafer, and D. Salvemini. 2021. Novel Non-Opioid Based Therapeutics for Chronic Neuropathic Pain. Mo Med 118:327.
  • Coppi, E., F. Cherchi, E. Lucarini, C. Ghelardini, F. Pedata, K.A. Jacobson, L. Di Cesare Mannelli, A.M. Pugliese, and D. Salvemini. 2021. Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A(3) Receptor Subtype. Int J Mol Sci 22:7952
  • Samson, W.K., D. Salvemini, and G.L.C. Yosten. 2021. Overcoming Stress, Hunger, and Pain: Cocaine- and Amphetamine-Regulated Transcript Peptide's Promise. Endocrinology 162:bqab108
  • Polinski NK, Martinez TN, Gorodinsky A, Gareus R, Sasner M, Herberth, M., Switzer, R., Ahmad, Syed O., Cosden, M., Kandebo, M., Drolet, R., Buckett, P., Shan, W., et al (2021) Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model. PLOS ONE 16(6): e0252325.
  • Banerjee, S., Ghoshal, S., Girardet, C., DeMars K.,Yang C., Niehoff, M., Nguyen A., Jayanth, P., Hoelscher, A., Xu, F., Banks, W., Hansen, K.,  Zhang, J., Candelario-Jalil E.,  Farr, S., Butler, A. , Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice. npj Aging Mech Dis 7, 23 (2021).
  • Chiarello, E. “Pharmacists Should Treat Patients Who Have Opioid Use Disorders, Not Police Them.” Journal of the American Pharmacists Association. 2021
  • Fillit H, Aigbogun MS, Gagnon-Sanschagrin P, Cloutier M, Davidson M, Serra E, Guérin A, Baker RA, Houle CR, Grossberg GT, Impact of Agitation in Long-Term Care Residents with Dementia in the United States.Int J Geriatr Psychiatry. 2021 Jul 19. doi: 10.1002/gps.5604. Online ahead of print.PMID: 34286877Lintel H, Corpuz T, Paracha SU, Grossberg GT. , Mood Disorders and Anxiety in Parkinson's Disease: Current Concepts, J Geriatr Psychiatry Neurol. 2021 Jul;34(4):280-288. doi: 10.1177/08919887211018267.PMID: 34219518
  • Grossberg G, Chand PR.; Guest Editors' Introduction From Dr. Grossberg and Dr. Chand, J. Geriatr Psychiatry Neurol. 2021 Jul;34(4):252. doi: 10.1177/08919887211018272.PMID: 34219523
  • Vogt K, Aryan L, Stealey S, Hall A, Pereira K, Zustiak SP. Microfluidic fabrication of imageable and resorbable polyethylene glycol microspheres for catheter embolization. J Biomed Mater Res A. 2021 Jul 21. doi: 10.1002/jbm.a.37271. Epub ahead of print. PMID: 34289220.
  • Raffin J, de Souto Barreto P, Aggarwal G, Nguyen AD, Morley JE, Li Y, Bateman RJ, Rolland Y, Vellas B, for the MAPT/DSA Group. (2021) Associations between physical activity, blood-based biomarkers of neurodegeneration, and cognition in healthy older adults: The MAPT study. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. 76(8):1382-1390. doi: 10.1093/gerona/glab094. PMID: 33864068
  • He L, Morley JE, Aggarwal G, Nguyen AD, Vellas B, de Souto Barreto P for the MAPT/DSA Group. (2021) Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults. Scientific Reports. 11(1), 13394. doi: 10.1038/s41598-021-91038-0. PMID: 34183688
  • Subhashis Banerjee, Sarbani Ghoshal, Clemence Girardet, Kelly M. DeMars, Changjun Yang, Michael L. Niehoff, Andrew D. Nguyen, Prerana Jayanth, Brittany A. Mersman, Fenglian Xu, William A. Banks, Eduardo Candelario-Jalil, Jinsong Zhang, Susan A. Farr and Butler AA. Adropin correlates with age-related neuropathologies in the human brain and improves neuroinflammation and cognitive function in aging mice. NPJ Aging & Mechanisms of Disease (accepted) (10.21203/
  • Butler AA and Havel PJ (2021). Adropin and Insulin Resistance: Integration of Endocrine, Circadian and Stress Signals Regulating Glucose Metabolism (Invited Perspective). Obesity (in press).
  • Segal GS, Xie SJ, Paracha SU, Grossberg GT., Psychosis in Parkinson's Disease: Current Treatment Options and Impact on Patients and Caregivers, J. Geriatr Psychiatry Neurol. 2021 Jul;34(4):274-279. doi: 10.1177/08919887211018280.PMID: 34219522
  • Lintel H, Corpuz T, Paracha SU, Grossberg GT. , Mood Disorders and Anxiety in Parkinson's Disease: Current Concepts, J Geriatr Psychiatry Neurol. 2021 Jul;34(4):280-288. doi: 10.1177/08919887211018267.PMID: 34219518
  • Fillit H, Aigbogun MS, Gagnon-Sanschagrin P, Cloutier M, Davidson M, Serra E, Guérin A, Baker RA, Houle CR, Grossberg G, Impact of Agitation in Long-Term Care Residents with Dementia in the United States.Int J Geriatr Psychiatry. 2021 Jul 19. doi: 10.1002/gps.5604. Online ahead of print.PMID: 34286877
  • Grossberg GT., Chand PR.; Guest Editors' Introduction From Dr. Grossberg and Dr. Chand, J. Geriatr Psychiatry Neurol. 2021 Jul;34(4):252. doi: 10.1177/08919887211018272.PMID: 34219523
  • Khoury R, Liu Y, Sheheryar Q, Grossberg GT., Pharmacotherapy for Frontotemporal Dementia, CNS Drugs. 2021 Apr;35(4):425-438. doi: 10.1007/s40263-021-00813-0. Epub 2021 Apr 11.PMID: 33840052
  • Li J, Guo C, Rood C, and Zhang J. A C-terminus-dependent conformational change is required for HDAC3 activation by nuclear receptor corepressors. Journal of Biological Chemistry. J Biol Chem. 297(4):101192. 2021.
  • Das, S., Postman, W.A., Haboubi, M., Akca, O., Remmel, K., Carter, A., & Zazulia, A. (2021, published online June 27). A Case of Aphemia Following Non-dominant Sub-insular Stroke: Unveiling the Foix-Chavany-Marie Phenomenon. Neurocase, DOI: 10.1080/13554794.2021.1933541
  • Tsegay KB, Adeyemi CM, Gniffke EP, Sather DN, Walker JK, Smith SEP. "A repurposed drug screen identifies compounds that inhibit the binding of the COVID-19 spike protein to ACE2." bioRxiv [Preprint]. 2021 Apr 8:2021.04.08.439071. doi: 10.1101/2021.04.08.439071. PMID: 33851160; PMCID: PMC8043450."
  • Postman, W.A., Rosenthal, S., Thompson, S., Sankey, L., Leisure, K., Ferron, R., Slay, T. & Fischer, M. (2021). "Forging Community Partnerships to Reduce Health Disparities in Low-Income African American Elders of North St. Louis at Risk for Dementia". Journal of the National Black Association for Speech-Language and Hearing, 16(1): 57-67.
  • L. Hill, J. Bruns, *S. P. Zustiak, “Hydrogel matrix presence and composition influences drug responses of encapsulated glioblastoma spheroids”, in press, 2021, Acta Biomaterialia (IF: 7.242); INVITED for Special Issue on “Biomaterials for Personalized Disease Models”
  • S. Stealey, A. Gaharwar, N. Pozzi, *S. P. Zustiak, “Development of Nanosilicate-Hydrogel Composites for Sustained Delivery of Charged Biopharmaceutics”, in press, 2021, ACS Materials & Interfaces (IF: 8.758)
  • Bordt AS, Patterson SS, Girresch RJ, Perez D, Tseng L, Anderson JR, Mazzaferri MA, Kuchenbecker JA, Gonzales-Rojas R, Roland A, Tang C, Puller C, Chuang AZ, Ogilvie JM, Neitz J, Marshak DW. Synaptic inputs to broad thorny ganglion cells in macaque retina. J Comp Neurol. 2021 Apr 12. doi: 10.1002/cne.25156. Epub ahead of print. PMID: 33843050.
  • Tewari, M., Khan, M., Verma, M., Mercier, P., Coppens, J., Kemp, J.M., Bucholz, R. & Egan, T.M. (2021) Physiology of cultured human microglia maintained in a defined culture medium. ImmunoHorizons  5:257-272. PMID: 33931497DOI:10.4049/immunohorizons.2000101.
  • Liang*, X., Janks*, L. & Egan, T.M. (2021, in press) Using Voltage Clamp Electrophysiology and Patch Clamp Photometry to Characterize P2X7 receptor currents. Methods in Molecular Biology. (*joint first authors).
  • Musicant AM, Parag-Sharma K, Gong W, Sengupta M, Chatterjee A, Henry EC, Tsai Y, Hayward MC, Sheth S, Betancourt R, Hackman TG, Padilla RJ, Parker JS, Giudice J, Flaveny CA, Hayes DN, Amelio AL, CRTC1-MAML2 Establishes a PGC1α-IGF1 Circuit that Confers Vulnerability to PPARγ Inhibition, Cell Reports, Vol. 34, Issue 8, 108768, Feb 23, 2021,
  • Nguyen K, Hoffman H, Chakkamparambil B, Grossberg GT, Evaluation of rivastigmine in Alzheimer's disease,  Neurodegener Dis Manag. 2021 Feb;11(1):35-48. doi: 10.2217/nmt-2020-0052.  Epub 2020 Nov 17. PMID: 33198569
  • Farr SA, Cuzzocrea S, Esposito E, Campolo M, Niehoff ML, Doyle TM, Salvemini D, Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury. J Neuroinflammation. 2020 Nov 12;17(1):339.
  • Durante M, Squillace S, Lauro F, Giancotti LA, Coppi E, Cherchi F, Di Cesare Mannelli L, Ghelardini C, Kolar G, Wahlman C, Opejin A, Xiao C, Reitman ML, Tosh DK, Hawiger D, Jacobson KA, Salvemini D. Adenosine A3 agonists reverse neuropathic pain via T cell-mediated production of IL-10. Journal of Clin. Invest. 2021 Feb 23:139299. doi: 10.1172/JCI139299. Online ahead of print. PMID: 33621215
  • Nasrallah, Henry A., Enduring the ordeal of a quadruple threat is especially arduous for psychiatric patients. Current Psychiatry. 2020 August; 19(8) 14-16, 37.
  • Nasrallah, Henry A., COVID-19 and the precipitous dismantlement of societal norms. Current Psychiatry. 2020 July; 19(7) 12-14, 16-17.
  • Nasrallah, Henry A., The cataclysmic COVID-19 pandemic: THIS CHANGES EVERYTHING!. Current Psychiatry. 2020 May; 19(5) 7-8,16.
  • Jung YH, Yu J, Wen Z, Salmaso V, Karcz TP, Phung NB, Chen Z, Duca S, Bennett JM, Dudas S, Salvemini D, Gao ZG, Cook DN, Jacobson KA. Exploration of Alternative Scaffolds for P2Y14 Receptor Antagonists Containing a Biaryl Core. J Med Chem. 2020. 10;63(17):9563-9589.
  • Doyle TM, Hutchinson MR, Braden K, Janes K, Staikopoulos V, Chen Z, Neumann WL, Spiegel S, Salvemini D., Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents. J Neuroinflammation. 2020 Oct 22;17(1):314.
  • R.R. Suresh, S. Jain, Z. Chen, D.K. Tosh, Y. Ma, M.C. Podszun, Y. Rotman, D. Salvemini, K.A. Jacobson, Design and in vivo activity of A3 adenosine receptor agonist prodrugs, Purinergic Signal, 16 (2020) 367-377.
  • S. Squillace, S. Spiegel, D. Salvemini, Targeting the Sphingosine-1-Phosphate Axis for Developing Non-narcotic Pain Therapeutics,  Trends in Pharmacological Science,  2020 Oct. 1.
  • F. Mufti, Y.H. Jung, L.A. Giancotti, J. Yu, Z. Chen, N.B. Phung, K.A. Jacobson, D. Salvemini, P2Y(14) Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model, ACS medicinal chemistry letters, 11 (2020) 1281-1286.
  • E. Lucarini, E. Coppi, L. Micheli, C. Parisio, A. Vona, F. Cherchi, A.M. Pugliese, F. Pedata, P. Failli, S. Palomino, J. Wahl, T.M. Largent-Milnes, T.W. Vanderah, D.K. Tosh, K.A. Jacobson, D. Salvemini, C. Ghelardini, L. Di Cesare Mannelli, Acute visceral pain relief mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels, Pain, (2020) DOI 10.1097/j.pain.0000000000001905(2020).
  • K.A. Jacobson, L.A. Giancotti, F. Lauro, F. Mufti, D. Salvemini, Treatment of chronic neuropathic pain: purine receptor modulation, Pain, 161 (2020) 1425-1441.
  • T.M. Doyle, T.M. Largent-Milnes, Z. Chen, V. Staikopoulos, E. Esposito, R. Dalgarno, C. Fan, D.K. Tosh, S. Cuzzocrea, K.A. Jacobson, T. Trang, M.R. Hutchinson, G.J. Bennett, T.W. Vanderah, D. Salvemini, Chronic Morphine-Induced Changes in Signaling at the A(3) Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal, J Pharmacol Exp Ther, 374 (2020) 331-341.
  • K. Braden, L.A. Giancotti, Z. Chen, C. DeLeon, N. Latzo, T. Boehm, N. D'Cunha, B.M. Thompson, T.M. Doyle, J.G. McDonald, J.K. Walker, G.R. Kolar, C.K. Arnatt, D. Salvemini, GPR183-oxysterol axis in spinal cord contributes to neuropathic pain, J Pharmacol Exp Ther, (2020) DOI 10.1124/jpet.120.000105(2020).
  • Arnatt, C. Estrogen receptor antagonist shows promise for treatment of gallstone disease. ASBMB Today. 2020 July 21.
  • Zhang, J, The transcriptional corepressor CBFA2T3 inhibits all-trans-retinoic acid–induced myeloid gene expression and differentiation in acute myeloid leukemia, has been selected as an Editors' Pick in the most recent issue of Journal of Biological Chemistry.  2020 May 17 ; 295(27) 8887–8900
  • Banerjee S, Farr S, Zhang J, Butler A, Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction. Journal of Biological Chemistry. 2020 July 29 
    Nasrallah, Henry A., During a viral pandemic, anxiety is endemic: The psychiatric aspect of COVID-19. Current Psychiatry. 2020 April;  19(4): e3-e5.
  • Chen Z, Doyle TM,Luongo L, Largent-Milnes TM, Giancotti LA, Kolar G, Squillace S, Boccella S,  Walker JK, Pendleton A, Spiegel S, Neumann WL, Vanderah TW and Salvemini D., Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain. PNAS. May 21;116(21):10557-10562.
  • Butler AA, Graham JL, Stanhope KL, Wong S, King S, Bremer AA, Krauss RM, Hamilton J, & Havel PJ (2020). Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi. J Lipid Res.
  • Gaynor M, Schneider D, Seltzer M, Crannage E, Barron ML, Waterman J, & Oberle A (2020). A user-centered, learning asthma smartphone application for patients and providers. Learning Health Systems.
  • Gordon-Fennell AG, Will RG, Ramachandra V, Gordon-Fennell L, Dominguez JM, Zahm DS, & Marinelli M (2020). The lateral preoptic area: A novel regulator of reward seeking and neuronal activity in the ventral tegmental area. Front Neurosci.
  • Green AT, Moniruzzaman M, Cooper CJ, Walker JK, Smith JC, Parks JM, & Zgurskaya HI (2020). Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold. Biochim Biophys Acta Gen Subj.
  • Guo C, Li J, Steinauer N, Wong M, Wu B, Dickson A, Kalkum M, & Zhang J (2020). Histone deacetylase 3 preferentially binds and collaborates with transcription factor RUNX1 to repress AML1-ETO-dependent transcription in t(8;21) AML. Journal of Biological Chemistry.
  • Haake A, Nguyen K, Friedman L, Chakkamparambil B, & Grossberg GT (2020). An update on the utility and safety of cholinesterase inhibitors for the treatment of Alzheimer’s disease. Expert Opin Drug Saf.
  • Mersman B, Jolly S, Lin Z, & Xu, F (2020). Gap junction coding innexin in Lymnaea stagnalis: Sequence analysis and characterization in tissues and the central nervous system. Frontiers in Synaptic Neuroscience.
  • Pan Y, Kafaie J, et al. (2020). Longitudinal 16-year study of dominant intermediate CMT type C neuropathy. Muscle Nerve.
  • Patterson SS, Bordt AS, Girresch RJ, Linehan CM, Bauss J, Yeo E, Perez D, Tseng L, Navuluri S, Harris NB, Matthews C, Anderson JR, Kuchenbecker JA, Manookin MB, Ogilvie JM, Neitz J, & Marshak DW (2020). Wide-field amacrine cell inputs to ON parasol ganglion cells in macaque retina. Journal of Comparative Neurology.
  • Steinauer N, Chun Guo C, & Zhang J (2020). The transcriptional corepressor CBFA2T3 is a general inhibitor of all-trans retinoic acid-induced myeloid gene expression and differentiation in AML. Journal of Biological Chemistry.
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  • Yosten GL, Harada CM, Haddock CJ, Giancotti LA, Kolar GR, Patel R, Guo C, Chen Z, Zhang J, Doyle TM, Dickenson AH, Samson WK, & Salvemini D (2020). GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents. J Clin Invest.


The faculty who are members of the Institute for Translational Neuroscience are highly respected and celebrated individuals. Below is a brief selection of recent awards these faculty have received.

Congratulations to Daniela Salvemini, Ph.D, William Beaumont Professor and Chair of the Department of Pharmacology and Physiology and Director of the Institute for Translational Neuroscience- She was just inducted as a Fellow of the American Society for Pharmacology and Experimental Therapeutics! Fellows are recognized for their meritorious efforts to advance pharmacology through their scientific achievements, mentorship, and service.

Congrats to Dr. Erick Messias on being named the August 2022 recipient of the Excellence in Professionalism Award through the Office of Professional Oversight.

  • Dr. Messias is the chair of psychiatry and behavioral neuroscience and was selected based on a nomination that highlighted his commitment and contributions to the learning environment. The Excellence in Professionalism Award recognizes educators (faculty, fellows, residents, students, nurses, administration, etc.) that exceptionally model the core principles of professionalism as stated below. Thank you, Dr. Messias, for your continued support of our educational mission and service to the School of Medicine!
    • Investment and engagement in learner education
    • Practices civility and an understanding of respect
    • Recognizes & honors the vast diversity within our learning environment
    • Displays patience, empathy and care
    • Is trustworthy and committed to the practice of medicine

2022 William Beaumont, M.D. Chair in Physiology Endowment

Daniela Salvemini, Ph.D., attended the university-wide investiture ceremony held on March 31, 2022.  She was honored with the William Beaumont, M.D. Chair in Physiology endowment.  

28th Annual Graduate Research Symposium

Rachel Schafer, a Ph.D. candidate in Dr. Salvemini’s lab, won second place for her poster presentation. 

The Institute for Translational Neuroscience Research Award, Jan. 2022

  • Gina Yosten, Ph.D., was the recipient. Her research was titled “Neuropeptides at the Intersection of Appetite and Stress: Role of CART and GPR160."
  • Andrew Butler, Ph.D., was the recipient. His research was titled “Development of GPR19 fusion proteins for analyzing agonist interactions and HTS campaigns.”  
  • Jinsong Zhang, Ph.D., was the recipient. His research was titled, “Exploring the role of G-protein pathway suppressor 2 in fetal brain development and neoplastic signals using innovative single-cell transcriptomics and knockout animal models.”

Daniela Salvemini, Ph.D., Awarded the 2021 Senior Faculty Scholarly Works Award

This award was for her paper published in the Journal of Clinical Investigation, "GPR160 deorphanization reveals critical roles in neuropathic pain in rodents." This award was presented by the Office of the Vice President for Research at the Grant winner and Scholarly Works reception on Friday, May 18, 3-5:30 p.m. in the Sinquefield Stateroom in DuBourg Hall. The annual ceremony celebrates research excellence and recognizes success in publications and grant submissions from the previous year.

F30 National Research Service Award

Monica Goodland, a Ph.D. candidate in Dr. Farr’s lab, was awarded an F30 National Research Service Award from the National Institute of Neurological Disorders and Stroke. This fellowship supports tuition, stipend, and fees for M.D./Ph.D. students, helping pave the road to becoming an independent physician-scientist. 

Sue Farr, Ph.D., Awarded Benter Foundation Grant

Congratulations to Dr. Sue Farr on her award from The Benter Foundation for a grant entitled "Vaccines for the Prevention of Alzheimer's Disease."

New Grants Awarded

Dr. Andrew Butler was recently awarded a subcontract for a grant from the NIH titled Neurovascular protection by adropin in acute neural injury from subarachnoid hemorrhage. Adropin is a small peptide discovered by Dr. Butler's laboratory nearly two decades ago. His group has made seminal contributions to understanding the physiological functions of this protein, with recent research linking adropin to brain health during aging. The PI of the NIH grant is Dr. Brian Hoh, James and Brigitte Marino Family Professor and Chair of the Lillian S. Wells Department of Neurosurgery at the University of Florida College of Medicine.

Subarachnoid hemorrhage is a form of stroke and involves bleeding into the space surrounding the brain. It is often fatal, and the only treatment options currently available are surgical. The goal of the project is to demonstrate the potential neuroprotective role of adropin in subarachnoid hemorrhage-associated cerebral infarction. The research will help to understand the potential therapeutic value of adropin to reduce brain damage and improve neurological recovery following subarachnoid hemorrhage and could lead to novel therapeutic strategies.

Dr. Gina Yosten Awarded $1,982,000 Grant by the Helmsley Charitable Trust

Dr. Gina Yosten, an associate professor of pharmacology and physiology, was awarded a $1,982,000 grant by the Helmsley Charitable Trust as part of a type 1 diabetes program initiative to prevent hypoglycemia. Hypoglycemia can lead to fainting, coma, or death and is the major obstacle to optimal glucose control for patients with type 1 diabetes. In previous studies funded by the Helmsley Charitable Trust and others, Dr. Yosten and colleagues determined that in rodents and isolated human tissue that delta cells in the pancreas produce neuronostatin, a hormone previously discovered by Dr. Yosten and her colleague, Dr. Willis Samson. Neuronostatin acts locally within the pancreas to stimulate alpha cells to secrete glucagon. This suggests that neuronostatin could be a useful therapeutic target for the prevention of hypoglycemia in patients with type 1 diabetes. Dr. Yosten will continue these efforts by determining how type 1 diabetes and the insulin analogs used to treat type 1 diabetes affect the production and function of neuronostatin both in isolated human islets and in human subjects. Dr. Yosten expects that this new project will confirm neuronostatin’s therapeutic value for preventing hypoglycemia in patients with type 1 diabetes.

NIH/NCI Awards a Five-Year $2,334,549 RO1: (2022-2027)

NIH/NCI awards a five-year $2,334,549 RO1 (2022-2027) to PIs Drs. Salvemini (Department of Pharmacology and Physiology) and Farr (Department of Internal Medicine). The grant, "Fingolimod and Ozanimod for the treatment and prevention of chemobrain," is the result of a fruitful four-year collaboration between the PIs and the Institute for Translational Neuroscience. The objectives of the research are to understand the molecular and cellular mechanisms within the central nervous system whereby chemotherapy (specifically platinum-based drugs and taxanes) engage signaling at the S1PR1 receptor that culminates in the development of cognitive impairment, a major neurotoxicity of widely used chemotherapeutics for which there are no FDA approved drugs. The outcome of the work is anticipated to provide foundational support to repurpose already FDA-approved S1PR1 antagonists to treat and prevent chemo-related cognitive deficits. 

NIH/NINDS Awards Five-Year $2,713,856 RO1 (RO1NS128004)

PIs Drs. Salvemini (Department of Pharmacology and Physiology) and Arnatt (Department of Chemistry) have been awarded a grant, "Uncovering the roles of oxysterols in neuropathic pain," the result of a fruitful five-year collaboration between the PIs and the Institute for Translational Neuroscience. The objectives of the research are to understand the molecular mechanisms engaged by oxysterols in the spinal cord in the development of central sensitization associated with chronic neuropathic pain states and the development of non-opioid-based therapies. Additional members of the team include Drs. John Chrivia and Tim Doyle and Karen Galen (Department of Pharmacology and Physiology).  

1R21HD107596-01 Awarded $757,500

Gina Yosten (Pharm/Phys) has been awarded an R21 "Exploration of the role of CART/GPR160 in metabolism in the setting of Magel2 deficiency: Implications for Prader Willi Syndrome". 06/10/2022 – 06/09/2024, $757,500

Five-Year NIH R01 Grant Supporting the Investigation of Novel Therapeutics

Daniela Salvemini, Ph.D., was awarded a five-year NIH R01 grant supporting the investigation of novel therapeutics developed in her laboratory and their application in migraine and orofacial pain. Drs. Akerman and Romero Reyes in the Department of Neural and Pain Sciences at UMSOD joined the collaboration.

The Department of Pharmacology Received a New, Five-Year NIHGMS T32 Training Program

The Department of Pharmacology received a new, five-year NIHGMS T32 Training Program in Pharmacological Sciences that provides one year of support for five students per year starting July 1, 2022. Students receive a stipend ($26,353), tuition and fees (up to $12,120), travel ($300), and childcare, if applicable ($2,500). This grant also supports travel to the annual ABRCMS and SACNAS meetings for one PI and a student and funds for an external speaker chosen by the participating students. Drs. John Walker, Gina Yosten, and Terrance Egan serve as MPIs. 

Daniela Salvemini, Ph.D. Awarded Department of Defense Grant

Dr. Daniela Salvemini was awarded a grant entitled “Sphingosine-1-Phosphate Receptor Subtype 1: A Novel Target in the Treatment of Chronic Migraine” from the Department of Defense. The funding period is July 1, 2021-June 30, 2025 and the funded amount is $1,280,322.  Migraine and post-traumatic headache (PTH) are widely prevalent disabling disorders. They are far more prevalent in military service personnel, as they are a common feature of mild traumatic brain injury, where a migraine predisposition is more likely to produce adverse outcomes.

Despite their high prevalence, there are major gaps in our understanding of their pathobiology. Moreover, our ability to treat the more frequent and chronically disabling forms of migraine and PTH are limited. The objectives of our proposal are to understand the roles of sphingolipids, and in particular S1P, in nociceptive mechanisms involved in the pathobiology of migraine-like headaches and the potential use of S1PR1 antagonists in these conditions.